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Mayo Clinic identifies key cellular process in prostate and other cancers

lular strategy for attaching an identifying marker to the tumor suppressor that targets it for destruction.
  • Skp2 is known to target several tumor suppressors for destruction.
  • FOXO1 is suited to being targeted for destruction via the ubiquitin pathway.

    The researchers noted that high levels of Skp2 were associated with low levels of FOXO1 in many human cancer cells, including prostate cancer -- and then combined the lines of evidence outlined above to design experiments to answer the specific question: Do elevated levels of Skp2 drive down and disable FOXO1, thus resulting in loss of its tumor suppression ability? The answer is yes.


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    • Contact: Robert Nellis
    newsbureau@mayo.edu
    507-284-5005
    Mayo Clinic
    14-Feb-2005


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