HOME >> MEDICINE >> NEWS
Mayo Clinic researchers create 'obedient virus'; First step to use measles virus against cancer

ROCHESTER, Minn. -- An international team of Mayo Clinic-led researchers is first to devise a system that consistently converts the measles virus into a therapeutic killer that hunts down and destroys cancer cells -- and cancer cells only. Their research findings appear in the current issue of Nature Biotechnology http://www.nature.com/nbt/.

The researchers harnessed the viral trait for attacking and commandeering cells, and then redirected the virus to attack diseased, rather than healthy cells. The work was done on laboratory animals implanted with two kinds of human cancer cells -- ovarian cancer and lymphoma -- and is probably still years away from use as a human therapy. But the concept has at last been proved in mice with human cancer tumors -- and that's an essential step toward using this approach to expand and improve human treatments for a variety of cancers.

The "Obedient Virus"

"When I saw the data, I was completely stunned. It's the sort of thing that, having worked on targeting viruses for about 15 years, I just couldn't believe that we'd finally got what we'd been hunting all that time," says Stephen Russell, M.D., Ph.D., lead researcher and director of Mayo Clinic's Molecular Medicine Program.

"It's very clean, very clear targeting. Our results show that we've efficiently ablated (destroyed) the ability of the measles virus to interact with its two natural receptors. And they also show that we can take our pick as to what new receptor we target and send the virus after it."

How They Did It

Using bioengineering techniques, the team reprogrammed the measles virus to seek a cancer cell to bind to instead of its natural binding partner. Then they invented a "molecular tag" that they attached to structures on the outside of the cancer-seeking measles virus. This tag is the key innovation of their work and central to the success of the team's investi
'"/>

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
2-Feb-2005


Page: 1 2

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Clinicians report missing patient information is common
9. Mayo Clinic discovers a key to low metabolism and major factor in obesity
10. Clinical trial of Etanercept for Wegeners disease shows no benefit
11. Mayo Clinic researchers identify new form of muscular dystrophy in adults

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/16/2018)... ... October 16, 2018 , ... Bastyr University ... Academy of Integrative Health and Medicine’s (AIHM) Visionary Award for his passionate efforts ... Dr. Pizzorno was selected as AIHM’s recipient of the Visionary Award due to ...
(Date:10/16/2018)... ... October 16, 2018 , ... 13th Annual ... http://www.fdanews.com/fdainspectionssummit , The 13th Annual FDA Inspections Summit starts in one ... sometimes feels difficult to keep up. The FDA is focused on any number ...
(Date:10/16/2018)... Texas (PRWEB) , ... October 16, 2018 , ... The months of training are over. ... last, their bodies will probably feel like they were put through the wringer after the ... and sports injuries team at Medicine in Motion on how to treat the body and ...
(Date:10/13/2018)... ... , ... At HEI Health, we believe tomorrow’s healthcare can be made affordable ... Healthcare CXO Fall Summit by Marcus Evans. HEI will be hosting an exclusive round ... with leading healthcare providers. , Marcus Evans National Healthcare CXO Summit is the ...
(Date:10/13/2018)... ... October 13, 2018 , ... This World Food Day – Tuesday, October 16 ... to end hunger by 2030 by breaking a GUINNESS WORLD RECORDS title with volunteers ... U.S. based locations and five international locations together to break the GUINNESS WORLD RECORDS ...
Breaking Medicine News(10 mins):
(Date:10/16/2018)... (PRWEB) , ... October 16, 2018 , ... ... today announced its participation in the American Academy of Ophthalmology’s (AAO) annual session. ... of Ophthalmology October 27-30 at McCormick Place in Chicago. AAO 2018 is a ...
(Date:10/16/2018)... ... October 16, 2018 , ... With suicide as the tenth leading ... the American Psychiatric Nurses Association (APNA) has released a new training to equip nurses ... deaths by suicide in hospital settings are preventable, a recent survey of 15,000 health ...
(Date:10/13/2018)... ... October 12, 2018 , ... David Young was the inventor ... in the Lockheed F22 Aircraft. Today, he announces the invention of the Two-Dimensional ... lead to sudden cardiac death (SCD). , The Two-Dimensional Arrhythmia Monitor has the ...
Breaking Medicine Technology:
Cached News: