Mayo Clinic researchers discover enzyme has potential to stop multiple sclerosis tissue damage

ROCHESTER, MINN. -- Mayo Clinic researchers have found a new clue in the search for a way to stop the tissue damage, or demyelination, that occurs in multiple sclerosis (MS) or related central nervous system diseases. They found a dramatic increase in a newly discovered degradative enzyme, myelencephalon-specific protease (MSP), in demyelinated tissue, indicating that inhibiting this enzyme could potentially block the process of tissue damage.

This is a first-ever finding of the link between MSP and the debilitation that patients experience in MS.

This study will be published in the June 2002 issue of Brain, published by Oxford University Press, http://brain.oupjournals.org/.

"If you could control this enzyme, you could possibly decrease the development of disease," said Isobel Scarisbrick, Ph.D., Mayo Clinic neuroscientist and lead author of this study. "Excess MSP, as is present in inflammatory central nervous system lesions such as those in MS, may promote demyelination."

Dr. Scarisbrick and colleagues discovered MSP in 1997 while she was a research fellow at Mayo Clinic in Jacksonville, Fla. They cloned MSP and developed probes and other tools to work with the enzyme and attempt to determine its role in demyelination.

In the researchers' investigation of mouse and human MS tissue, they discovered MSP's dramatic increase in inflammatory cells in actively demyelinating human MS lesions. MSP is a multifunctional enzyme, facilitating entry of inflammatory cells into the brain and also contributing to tissue destruction when overexpressed. It also may harm processes of the oligodendroglia, cells found in the central nervous system that form the myelin sheath protecting the axon, a component of nerve cells. When functioning normally, however, MSP contributes to proper oligodendroglia function.

In the MS field, researchers have made many strides in learning about the

Contact: Lisa Copeland
Mayo Clinic

Page: 1 2

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:

(Date:8/31/2020)... , ... August 31, 2020 , ... ... donated 1,400 N95 face masks to medical first responders across the United States. ... make donations of personal protective equipment (PPE) medical centers , hospitals ...
(Date:8/31/2020)... AURORA, Colo. (PRWEB) , ... August 31, 2020 ... ... premier provider of innovative higher-learning opportunities through high-quality, career-relevant, and affordable online education ... Emergency Responder Psychology . , Among the first of its kind in ...
(Date:8/31/2020)... ... 2020 , ... A Cure for Covid-19 “PTS” with Mediation & Hypnosis , At this ... state of panic, experiencing deep anxiety, immense stress, and right now are needing serious relief ... most people on the planet are experiencing a great degree of emotional discomfort, be it ...
(Date:8/31/2020)... ... August 31, 2020 , ... Bonde Innovations, LLC, a venture-backed ... heart failure, today announced that the company has been awarded a Phase 1 ... National Heart, Lung, and Blood Institute of the National Institutes of Health (NIH). ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... designed to help treat patients with respiratory conditions, including COVID-19, while reducing the ... and oxygen, but it captures exhaled gas and scrubs it free of carbon ...
Breaking Medicine News(10 mins):
(Date:8/28/2020)... ... August 28, 2020 , ... Dr. Mark Surrey has been in ... serves as a clinical professor in the Department of OBGYN at UCLA’s David Geffen ... & Pacific Coast Reproductive Society and is a Clinical Director of Fellowship Training for ...
(Date:8/27/2020)... ... 2020 , ... Bleep LLC, maker of the DreamPort mask-less CPAP solution, announced ... new spokesperson. , “In my line of work, a good night of sleep is ... it was a Bleeping no brainer for me,” said Jensen. “From the moment I ...
(Date:8/26/2020)... ... , ... AseptiScope, a privately funded San Diego, California based, clinical innovation company, ... , “AseptiScope is pleased to receive this recognition,” said Kelly Powers, AseptiScope ... their hands, goggles on their eyes, covers on their shoes, and gowns on their ...
Breaking Medicine Technology:
Cached News: