HOME >> MEDICINE >> NEWS
Mayo Clinic researchers discover gene mutations that 'ignore' stress, lead to heart failure

ROCHESTER, Minn. -- Mayo Clinic researchers have discovered genetic mutations in heart patients that make them vulnerable to heart failure because they produce an abnormal protein that can't decode stress messages from the body.

Mayo researchers are the first to realize that these proteins do not recognize the stress alarm. As a result, they can't properly respond to cue adjustments within the heart that normally manage stress. These defects make the heart muscle susceptible to damage. The Mayo Clinic research team's report appears in the journal Nature Genetics, v. 36; no. 4, April 2004 (www.nature.com).

Research team leader Andre Terzic, M.D., Ph.D., a specialist in cardiac biology, describes the work as groundbreaking because it reveals critical molecular mechanisms which may in turn point to possible new treatments for heart failure. "Very little is known about stress tolerance of the heart in health and disease," says Dr. Terzic. "This discovery opens a new field of investigation in cardiovascular medicine as we uncover how and why the heart becomes vulnerable to stress."

In addition to collaborating with other researchers from Mayo Clinic, Dr. Terzic's team drew upon the expertise of the University of Minnesota Supercomputing Center to help model the shape of the protein under investigation.

Significance of the Findings

The significance of the Mayo Clinic findings is threefold. It: 1) for the first time, views heart failure as a communication or signaling problem in the stress-management system of heart cells, 2) tests the idea in human beings, and 3) offers convincing evidence that miscommunication of stress signals distresses the heart and plays a role in susceptibility to heart failure.

This work differs from most research into genetic causes of heart failure which has identified defects in proteins involved in the mechanics of cardiac pumping, not in the communicat
'"/>

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
29-Mar-2004


Page: 1 2 3

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2018)... (PRWEB) , ... December 06, 2018 , ... ... Wilson, Medicare Analytic Consultant Senior of Blue Cross and Blue Shield of Kansas ... Interrelated” on Tuesday, December 11, 2018 at 2:15pm PT at the Fairmont Grand ...
(Date:12/5/2018)... ... December 05, 2018 , ... Bellus ... is setting a new standard as the premier FDA-cleared microneedling device. This award ... this award is presented at the renowned Aesthetics Awards to products launched in ...
(Date:12/5/2018)... ... , ... A well-known name in the world of gyms and fitness centers ... which has delivered on-demand, virtual fitness programming to employers, gyms and fitness centers, and ... the Apple App Store, the Wellbeats app is fitness that fits for people of ...
(Date:12/5/2018)... (PRWEB) , ... December 05, 2018 , ... ... FSP, Strategic Resourcing, and Consulting services, announced its new office location in Paris, ... accommodate organic growth of clinical trial operations in Europe and additional in-country personnel. ...
(Date:12/5/2018)... ... 05, 2018 , ... Northcentral University (NCU) has today announced the launch of ... on a weekly rolling basis to registered nurses, the Master of Science in ... will prepare degree candidates to become leaders in the high-demand field. , ...
Breaking Medicine News(10 mins):
(Date:12/5/2018)... ... December 05, 2018 , ... ... management announced the hiring of Dr. Tony Andrulonis, MBA to lead company-wide operational ... of over 20,000 medical scribes and support staff. Prior to joining HealthChannels, Andrulonis ...
(Date:12/5/2018)... ... December 04, 2018 , ... Florida Hospital West Florida Division ... Today, the prestigious Leapfrog Group, a national nonprofit health care ratings organization, announced ... Medical Center Sebring, Florida Hospital Wesley Chapel and Florida Hospital Zephyrhills all received ...
(Date:12/5/2018)... ... December 05, 2018 , ... Join the ... meeting is an interdisciplinary biofeedback conference to nurture communication and education between specialists ... other disciplines come together to share and learn. The meeting offers a broad ...
Breaking Medicine Technology:
Cached News: