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Mayo Clinic researchers discover gene mutations that 'ignore' stress, lead to heart failure

hannel at a Glance

In healthy people, the potassium channel synchronizes the proper balance of potassium and calcium flow in the heart. Calcium is needed for the heart's contractions. A proper level of potassium enables the cells to restore electrical balance following each heartbeat, and limits the entrance of calcium into the cells. Too much calcium damages cell structure and leads to heart failure.

The new finding shows ATP-sensitive potassium channels can work as defensive barriers, and if they are defective they cannot properly sense the body's state of stress. When this happens, they fail to decode the metabolic signals that synchronize the flow of potassium and calcium.

Implications of Research

In principle, researchers can apply these findings to other patients with heart failure and look for other stress-reactive proteins that miscommunicate vital electrical or mechanical responses. Dr. Terzic says the ultimate goal is to design better therapies for managing heart disease.


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Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
29-Mar-2004


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