HOME >> MEDICINE >> NEWS
Mayo Clinic researchers discover how key cancer protein works

ROCHESTER, Minn. -- Mayo Clinic researchers are the first to describe what goes wrong during the growth cycle of certain cells that can lead to inherited forms of breast cancer. Knowing the nature of this biochemical modification is a first step to designing drugs that can correct it to stop cancer.

The Mayo Clinic research finding appears in today's issue of the journal Science (www.sciencemag.org/content/current ). It is important because it solves an aspect of a mystery that cancer researchers worldwide have been intensely investigating. Their question is: How do the regulating mechanisms of the "cell-cycle" work?

The cell cycle is the complex, natural -- and normally orderly -- process by which cells reproduce. The Mayo Clinic research reveals the details of a molecular mechanism involved in cell cycle regulation of a gene known as the "BRCA1 tumor suppressor gene." They focused on this gene because an estimated 50 percent of inherited breast cancers are linked to growth errors -- also called mutations -- in this gene. They hypothesized that a specific kind of biochemical modification was involved in disrupting the cell cycle to cause BRCA1 mutations. And they were right.

"With this breast cancer gene, the understanding is that if this gene is mutated it may trigger additional mutations throughout your lifetime and that contributes to a lifetime risk of developing breast cancer. We wanted to understand the molecular mechanism behind this," says Junjie Chen, Ph.D., of the Mayo Clinic Department of Oncology, and lead author of the Science report. "Now that we understand one aspect of it, this allows us to go to the next level, such as how to use our understanding to target cells so we can gain control of the cell cycle to stop cancers."

In the language of science, their principal finding is this: That a specific biochemical modification known as "phosphorylation
'"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-2511
Mayo Clinic
23-Oct-2003


Page: 1 2 3

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mayo Clinic researchers discover how key cancer protein works

(Date:8/27/2015)... Costa Mesa, CA (PRWEB) , ... August 27, 2015 , ... ... in to get help, leaving weeks or months later, relapsing and returning again, all ... accidents under the influence while in sober living homes or soon after leaving facilities ...
(Date:8/27/2015)... ... August 27, 2015 , ... Workflow ... quantitative PCR (qPCR) in the last decade. New features such as ... costs. On the flipside, where do lab managers, technicians, and researchers find handy ...
(Date:8/27/2015)... Los Angeles, CA (PRWEB) , ... August 27, 2015 , ... ... Diabetes Association and the American Heart Association have released new guidelines to educate doctors ... that the last update to these particular guidelines came in 2007, so the new ...
(Date:8/27/2015)... ... ... Thriveology Founders, Dr. Carly Letzt Carney and Dr. Mark Carney announced today that ... on Saturday, August 29, 2015 at the Marriott DTC, 4900 S. Syracuse Street, Denver, ... will present a two part seminar entitled, “How to Thrive as You Age & ...
(Date:8/27/2015)... ... August 27, 2015 , ... In mid-May, ... marijuana industry with the launch of its Doobster platform, a HIPAA-compliant mobile application ... products from their smart phones and tablets. Well, Doobster, “The App That ...
Breaking Medicine News(10 mins):Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 2Health News:National Screenings of Documentary Indicate Burgeoning Questions about the Effectiveness of Addiction Treatment Facilities 3Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 2Health News:Douglas Scientific® Webinar Outlines Comparisons of Varied qPCR Instruments 3Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 2Health News:Article on New Diabetic Care Guidelines Shines Brightly on Weight Loss Surgery, notes Beverly Hills Physicians 3Health News:Internationally-renowned Naturopathic Doctor and Chiropractor Team up to Reveal Secrets of Avoiding Disease 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 2Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 3Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 4Health News:Doobster Launches a Nationwide, Comprehensive On-Demand Medical Marijuana App 5
(Date:8/27/2015)... 2015  Mytrus, a technology and services company revolutionizing clinical trials, ... consent has received approval for use by ... the first time e-Consent technology will be used in ... Mytrus was also the first electronic informed ... by the U.S. Food and Drug Administration in 2011. ...
(Date:8/27/2015)... , Aug. 27, 2015  Lightwave Logic, ... the development of Next Generation Photonic Devices ... applications in high speed fiber-optic data communications and ... Lebby has been appointed to the Company,s ... in the field of optoelectronics is widely recognized ...
(Date:8/27/2015)... 2015 WuXi PharmaTech (Cayman) Inc. (NYSE:  WX), a ... company serving the pharmaceutical, biotechnology, and medical ... and manufacturing subsidiary Shanghai SynTheAll Pharmaceutical Co., ... the Japan PMDA for the manufacture of ... drug in July. STA is now the ...
Breaking Medicine Technology:Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 2Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 3Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 4Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 5Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 6Britain's National Health Service Approves The Use Of Mytrus Technology For Electronic Informed Consent In Clinical Trials 7Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 2Lightwave Logic Announces the Appointment of Optoelectronics Industry Leader, Michael Lebby, Ph.D. to its Board of Directors 3WuXi PharmaTech's STA Subsidiary Receives First Approval from Japanese Regulatory Authorities 2
Cached News: