HOME >> MEDICINE >> NEWS
Mayo Clinic researchers discover how key cancer protein works

" (fos-for-a-LAY-shun) is required at certain cell-cycle stages to activate proteins associated with the BRCA1 gene. These proteins are essential to the effective tumor-suppression function that BRCA1 genes perform.

Biology Backgrounder

Genes are strings of DNA molecules. They are found on chromosomes within cell nuclei. DNA is like a storage bin for vital information -- like the hard drive of a computer. To be useful, a computer hard drives needs to run a program that performs work. It's the same with DNA. To be useful, it runs programs (RNAs) that make desired products. The products are proteins. Proteins are the substances that carry out all life functions, which is why advanced cancer research focuses on them.

To do their jobs, proteins need to be activated. They become activated by binding to other protein partners. The Mayo Clinic team investigated a specific kind of protein the BRCA1 gene codes for, known as a BRCT-domain protein. The BRCT-domain influences how the protein binds and with what protein partners it binds -- which in turn, affects the role the protein plays in the cycle of cell growth. BRCT domains are found in many proteins involved in cell-cycle regulation, and have for some years been thought to be key players in cell-cycle regulation. But just how they did so was not known.

The Mayo Clinic Research Solves The Mystery

The Mayo team showed that phosphorylation of a binding partner is necessary to activate the BRCT-domain protein. Once activated, the BRCT-domain protein then helps regulate vital tasks in the cell cycle. These tasks include repairing DNA or signaling DNA damage. When these tasks are accomplished, the BRCA1 gene can function correctly to suppress tumors. Without phosphorylation of BRCA1 binding partners, BRCA1 cannot function to suppress tumors. This leaves cells vulnerable to the cumulative mutations that can eventually produce breast cancer.

Implications for Pa
'"/>

Contact: Robert Nellis
newsbureau@mayo.edu
507-284-2511
Mayo Clinic
23-Oct-2003


Page: 1 2 3

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mayo Clinic researchers discover how key cancer protein works

(Date:9/2/2015)... ... September 02, 2015 , ... Every year at this time, students ... However, few are prepared to face the academic workload confronting them. They just don’t ... prepared them since schools don’t teach students how to study. , “Bankers bank. Salesmen ...
(Date:9/2/2015)... Destin, Florida (PRWEB) , ... September 02, 2015 , ... ... in drug prices over the past year and its negative impact on consumers. It ... regular prescription medication and 10% were paying as much as an extra $100 compared ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... patented products, announces Hand Free Pocket Cop, a safety invention that protects people ... US is worth $31 billion," says Scott Cooper, CEO and Creative Director of ...
(Date:9/2/2015)... (PRWEB) , ... September 02, 2015 , ... ... Fort Lauderdale, CENTURION SERVICE GROUP is internationally known as an industry leader specializing ... house in the world, selling more than 100,000 pieces of medical equipment every ...
(Date:9/2/2015)... ... ... Ovarian cancer continues to be the deadliest of all gynecologic cancers. According to ... is approximately 1 in 75. This year it is estimated that approximately 22,000 women ... There is no test to detect ovarian cancer. A Pap test does not detect ...
Breaking Medicine News(10 mins):Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 2Health News:5 Essential Study Tips Every Student Needs for Academic Success but Schools Do Not Teach 3Health News:Watertree Health President Responds to Consumer Reports Survey on Rising Prescription Drug Prices 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 2Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 3Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 4Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 5Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 6Health News:What Should You Be Watching As You Walk Alone At Night - World Patent Marketing's Hand Free Pocket Cop Invention 7Health News:Over 1800 Lots of Surplus Used Medical Equipment 2Health News:Over 1800 Lots of Surplus Used Medical Equipment 3Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 2Health News:National Ovarian Cancer Coalition's DFW Chapter Features First Annual Teal Lights Display This Friday, September 4th, "National Wear Teal Day" 3
(Date:9/2/2015)... 2015 About Neuroendovascular Coil ... an unruptured and ruptured brain aneurysm (a weakened ... either known as an endovascular coiling or endovascular ... the blood flow in an aneurysm. The endovascular ... by an interventional neuroradiologist using fluoroscopic imaging guidance. ...
(Date:9/2/2015)... 2, 2015 About Chronic Lymphocytic Leukemia ... characterized by increased production of lymphocytes. It has been ... it can spread to other parts of the body. ... of the slow buildup of the cancerous cells. During ... the spleen, liver, and lymph nodes. The course of ...
(Date:9/2/2015)... 2, 2015 Research and Markets ( http://www.researchandmarkets.com/research/275q7t/inhaled_drug ... Drug Delivery (London, UK - November 19-20, 2015)" ... Delivery meeting will cover industry case studies, regulatory updates, ... Co-Chairmen are Dr Steven Nichols , OINP Specialist ... Companies participating include: ...
Breaking Medicine Technology:Global Neuroendovascular Coil Market 2015-2019 2Global Chronic Lymphocytic Leukemia Therapeutics Market 2015-2019 2Global Chronic Lymphocytic Leukemia Therapeutics Market 2015-2019 3
Cached News: