HOME >> MEDICINE >> NEWS
Mayo Clinic researchers identify new form of muscular dystrophy in adults

ROCHESTER, Minn. -- Mayo Clinic researchers have identified a previously unknown form of muscular dystrophy, a group of genetic diseases characterized by progressive weakness and muscle degeneration. This newly identified form develops after age 40 and causes heart muscle damage, limb muscle weakness and nerve damage. The researchers have named the newly defined disorder "zaspopathy" (Zas-PO-path-ee).

Some 50,000 Americans have some form of muscular dystrophy, and there are currently no cures. Mayo Clinic researchers note that their work may help contribute to a cure because it increases the understanding of the muscular dystrophy disease process and the role genes play in it. They say their research is a crucial first step toward discovering treatments, because genes offer a promising target at which aim new therapies. The report on the discovery will appear in the Jan. 26 online version of the journal Annals of Neurology (http://www3.interscience.wiley.com/cgi-bin/jissue/78504407).

The Mayo Clinic researchers found that any one of three mutations in the gene that supplies the instructions for creating a protein known as " ZASP" can cause the newly defined disorder. The genes involved in zaspopathy are passed along to offspring in a dominant manner. This means that a child will develop the disorder by inheriting one copy of the mutant gene from one parent. The Mayo Clinic researchers tentatively named the new syndrome "zaspopathy" after the affected ZASP protein.

Significance of the Mayo Clinic Research

The identification of this new form of muscular dystrophy highlights the importance of scientific collaborations and the integration of different kinds of data. Laboratory information from ZASP alone was not enough to clarify the finding; clinical data from a large patient base was also necessary to support the clues given by ZASP. "The fact
'"/>

Contact: Lisa Lucier
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
26-Jan-2005


Page: 1 2 3

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
(Date:8/22/2014)... News) -- The air in American cities is getting ... Thursday. Significant progress has been made in reducing ... decades, the agency said in a news release. ... reduction in mercury from human sources such as coal-fired ... 84 percent fall in lead, which harms brain development ...
(Date:8/22/2014)... leather seat covers provided by Lseat.comare meticulously in house ... needs. Recently, the company has unveiled its latest assortment of ... wants to provide worldwide clients with more high quality items. ... a long time. According to the company’s sales manager, all ... all the new products, Chevrolet Camaro leather seat covers ...
(Date:8/22/2014)... NY (PRWEB) August 22, 2014 ... Chinese orthopedic instrument industry, some foreign and domestic ... instrument market though mergers and acquisitions. In 2012, ... maker in China-- China Kanghui Holdings for USD ... China’s largest trauma product makers-- Trauson Holdings Company ...
(Date:8/22/2014)... The graft-versus-host disease (GVHD) treatment market value will ... by 2018, at a Compound Annual Growth Rate (CAGR) ... – Opportunity Analysis and Forecasts to 2018” states that ... (6MM: the US, France, Germany, Italy, Spain and the ... (5EU), where multiple product launches will accelerate the market ...
(Date:8/22/2014)... 2014 Tug McGraw Foundation and Team McGraw ... to participate in the 39th Annual Marine Corps Marathon on ... will join forces in coaching, training and participation for the ... our nation's capital and is often referred to as the ... Corps Marathon is the largest marathon in the world that ...
Breaking Medicine News(10 mins):Health News:Air in U.S. Cities Getting Cleaner, EPA Says 2Health News:Custom 1993-1996 Chevrolet Camaro Leather Seat Covers Now for Sale at Lseat.com 2Health News:China Orthopedic Instrument Industry 2014- Global Industry Size, Share, Trend, Growth and Forecast 2017 2Health News:Graft-Versus-Host Disease Treatment Market Worth $409.0m by 2018 Says a New Report Available at MarketOptimizer.org 2Health News:Graft-Versus-Host Disease Treatment Market Worth $409.0m by 2018 Says a New Report Available at MarketOptimizer.org 3Health News:Graft-Versus-Host Disease Treatment Market Worth $409.0m by 2018 Says a New Report Available at MarketOptimizer.org 4Health News:Tug McGraw Foundation and Team Red White and Blue Join to Run in Marine Corps Marathon 2Health News:Tug McGraw Foundation and Team Red White and Blue Join to Run in Marine Corps Marathon 3
(Date:8/21/2014)... BreedIT Corp., (OTCQB: BRDT) ... worldwide license holder and distributor of highly sophisticated ... today is pleased to announce the formation of ... a leading Israeli medical Cannabis breeder. ... breeds of medical Cannabis to meet the requests ...
(Date:8/21/2014)... Aug. 21, 2014  AliveCor, Inc. announced ... Administration (FDA) has granted the company clearance ... (AFib), the most common form of cardiac ... detects if patients are experiencing AFib through ... mobile phone based AliveCor® Heart Monitor, so ...
(Date:8/21/2014)... 2014   Royal Philips (NYSE: ... has received 510(k) clearance from the U.S. Food ... application for Transcatheter Aortic-Valve Implantation (TAVI) treatments. Through ... with pre-procedural, high-precision positioning to treat aortic stenosis ... is available as part of Philips IntelliSpace ...
Breaking Medicine Technology:BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 2BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 3BreedIT Ltd. and Seach Ltd. Form KanaboSeed to Develop New Medical Cannabis Varieties 4AliveCor Receives First FDA Clearance to Detect a Serious Heart Condition in an ECG on a Mobile Device 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 2Philips receives FDA 510(k) Clearance for TAVI Precision Treatment Planning Application 3
Cached News: