HOME >> MEDICINE >> NEWS
Mayo Clinic study shows no adverse heart effect for sildenafil (Viagra)

ROCHESTER, MINN. -- Using ultrasound images of the heart during exercise, Mayo Clinic researchers have shown for the first time that sildenafil citrate (Viagra) does not adversely affect blood flow to the heart in men with stable coronary artery disease who are not taking nitrates. The findings appear in this weeks Journal of the American Medical Association (JAMA).

The study, which was funded by the American Heart Association and by Mayo Clinic, involved administering two exercise echocardiograms to 105 men with known or probable coronary artery disease. The testing was done on a reclining exercise bicycle to allow continuous ultrasound imaging of the heart, and it was combined with an electrocardiogram (ECG) to monitor the hearts electrical activity. One stress test was given an hour after taking sildenafil and the other after taking a sugar pill. Both the patients and the researchers were blinded to when they were testing the drug and when they were using the placebo.

"In these patients, sildenafil had no adverse effect on symptoms or how long the men were able to exercise," says Patricia Pellikka, M.D., a Mayo Clinic cardiologist and the lead investigator for the study. "We expected and saw that echocardiograms of these heart disease patients would show evidence of inadequate blood supply to the heart muscle during exercise. The key finding, however, is that the problem was not made worse by sildenafil."

Because previous studies have shown that nitrates combined with sildenafil can lead to serious decreases in coronary blood flow and blood pressure, the men were required to stop taking nitrates at least three days before participating in this study.

Dr. Pellikka says the study has important implications for patients and physicians. "While 105 patients is not a large enough number to absolutely predict cardiac events, especially among particular subgroups, the overall message is that sildenafil does not increase oxygen deprivat
'"/>

Contact: Lee Aase
aase.lee@mayo.edu
507-266-2442
Mayo Clinic
12-Feb-2002


Page: 1 2

Related medicine news :

1. Mayo Clinic discovers new pathway against pancreatic cancer
2. Mayo Clinic develops first genomic-based test to predict stroke from ruptured brain aneurysm
3. Mayo Clinic study sets threshold for valve repair surgery
4. Mayo Clinic researcher calls for improved newborn screening
5. Mayo Clinic study finds obese kidney donors face few increased risks
6. Mayo Clinic identifies key cellular process in prostate and other cancers
7. Clinical breast examination offers modest benefit to breast cancer screening program
8. Mayo Clinic researchers create obedient virus; First step to use measles virus against cancer
9. Clinicians report missing patient information is common
10. Mayo Clinic discovers a key to low metabolism and major factor in obesity
11. Clinical trial of Etanercept for Wegeners disease shows no benefit

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/22/2018)... ... September 22, 2018 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... Lymphoma Research Ride, a cycling event held each year during Blood Cancer Awareness ...
(Date:9/13/2018)... ... September 13, 2018 , ... Nash Family ... Month to educate their patients and the general public on the value of ... Not only do Drs. Nash have extensive training in helping those with periodontal ...
(Date:9/12/2018)... ... September 12, 2018 , ... Today, Sterling , a rope ... attempted the first unassisted adaptive climb of the Lotus Flower Tower in Canada’s Cirque ... difficult for him to lead, the duo decided to persevere and with some assistance ...
(Date:9/7/2018)... ... September 07, 2018 , ... ... personal-care products with a presence worldwide, today announced that its Chief Executive Officer, ... in Entrepreneurship. Ms. Ishaq will be presented the award on Friday, September 7, ...
(Date:9/3/2018)... , ... September 03, 2018 , ... Trees with fall ... should be in full leaf and green through September. When a tree is under ... before other trees of the same type. Giroud Tree and Lawn provides ...
Breaking Medicine News(10 mins):
(Date:9/13/2018)... ... September 13, 2018 , ... ... effective August 31, 2018, making its regional Texas Home Health operations the ... including home health, hospice, and personal care services. , Texas Home Health operations ...
(Date:9/12/2018)... ... September 12, 2018 , ... Surgical Theater will be ... from September 19-22. The IT + Revenue Cycle Conference provides Surgical Theater with ... the use of Precision Virtual Reality™ medical visualization platform. This 360VR technology allows ...
(Date:9/7/2018)... ... , ... CTL Medical Corporation has entered into a definitive ... includes its complete portfolio of spine-related patents and 510ks, as well as any ... will make CTL Medical the world’s exclusive provider of silicon nitride spine products ...
Breaking Medicine Technology:
Cached News: