HOME >> MEDICINE >> NEWS
Mayo researchers invent targeted imaging probe to aid early Alzheimer's diagnosis

is made only on the basis of finding amyloid plaques during autopsy. Most Alzheimer's patients are tentatively diagnosed with the disease on the basis of behavioral evaluations.

The probe also may be used to evaluate the effectiveness of new Alzheimer's therapies that are now being designed to retard the development of the destructive brain lesions that are the hallmark of the disease. Amyloid plaques are abnormal buildups of proteins that interfere with brain communication and produce typical Alzheimer's symptoms. These include: deep and chronic forgetfulness, and loss of awareness.

The Experiment

The Mayo Clinic research team of neurologists, neuroscientists, biochemists and peptide synthesis specialists designed a derivative of the human amyloid-beta peptide (the molecule that contributes to plaque formation) to create a new kind of molecular probe. To test its targeting ability to find amyloid plaques in laboratory Alzheimer's disease mice, the researchers injected the probe it into the bloodstreams of the living mice.

The probe demonstrated the strong ability to bind to amyloid plaques in mice, increased permeability at the blood-brain barrier, and contrast enhancement in MRI scans.

Researchers also tested the probe in laboratory specimens of human Alzheimer's brains donated by families for biomedical research. While it behaved slightly differently in human brain specimens than in living mice, the probe's ability to label plaques was encouraging.

The Next Step

Further work in animal models must be carried out before the new probe could move to human trials. Says Dr. Poduslo: "While the present work underscores the development of this contrast agent for use in Alzheimer's disease, the biotechnology reported here may provide a general procedure for enhancing delivery of other diagnostic and therapeutic proteins across the blood-brain barrier for other neurodegenerative disorders as well."


'"/>

Contact: Bob Nellis
newsbureau@mayo.edu
507-284-5005
Mayo Clinic
30-Apr-2004


Page: 1 2 3

Related medicine news :

1. Indiana University researchers closer to helping hearing-impaired using stem cells
2. Protein that helps skin cancer spread identified by Stanford researchers
3. US life expectancy about to decline, researchers say
4. Gene for age-related macular degeneration discovered by Yale researchers
5. Dartmouth researchers find where musical memories are stored in the brain
6. Columbia researchers receive $3 million to combat genetic killer of infants & toddlers
7. US cancer researchers launch first American-Israeli cancer conference
8. USC dental researchers develop first test for predicting cavities in children
9. Young blood revives aging muscles, Stanford researchers find
10. Uric acid may help reduce effects of spinal cord injury, Jefferson researchers find
11. Age should not be a factor in determining heart transplantation eligibility, researchers say

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/11/2018)... Ga. (PRWEB) , ... August 10, 2018 , ... ... is known for providing innovative procedures to metro Atlanta. Drs. Brent Sharpe and ... at Northeast Georgia Medical Center in Braselton. , On June 27, the physicians ...
(Date:8/9/2018)... ... August 09, 2018 , ... ... LegitScript is a new verification process that substance abuse providers must pass in ... means we can reach more people to help.” , Helping people is ...
(Date:8/7/2018)... ... August 07, 2018 , ... Josh Sprague, Founder and CEO of ... preview for the upcoming Leadville 100 MTB. , Accompanied by colleague Marvin Sandoval ... he has called “one of the most iconic mountain bike race courses in the ...
(Date:8/3/2018)... ... August 03, 2018 , ... Firstaid4sport ... Gerry Newlove first started the Firstaid4sport business in the 1990's and his son ... one of the leading providers in the UK of sports medicine products, supplying ...
(Date:8/2/2018)... ... August 02, 2018 , ... Dr. Srini Pillay , best-selling ... of why some people could care less, demonstrating a “whatever” attitude toward life, people, ... reasons for this, one often overlooked reason relates to being overworked. Called self-regulation depletion ...
Breaking Medicine News(10 mins):
(Date:8/2/2018)... ... August 02, 2018 , ... Periodontist, Dr. Andres Sanchez, ... crown lengthening treatment at his Eden Prairie, MN practice. Aesthetic crown lengthening ... Using decades of experience, Dr. Sanchez is excited to welcome new patients for ...
(Date:8/2/2018)... , ... August 02, 2018 , ... ... humanitarian efforts, is an inspiring, international leader of sustainable advocacy. Sharon Kleyne, host ... Pharma®, The Power of Water® & Your Health sponsored by Nature’s Tears® EyeMist® ...
(Date:8/2/2018)... ... August 02, 2018 , ... The Team from Hennessey ... major milestone with the production of a limited production commemorative vehicle: The 2019 ... Hennessey Mustang’s 5.0L supercharged V8 engine produces 808 horsepower at 7,200 rpm and 677 ...
Breaking Medicine Technology:
Cached News: