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Mechanism found behind drug-free acceptance of transplants

ertain cytokines -- proteins involved in immune regulation. Sure enough, when one of two cytokines (TGF-B and IL-10) were inhibited at the DTH site, the footpads swelled up. "It showed that the DTH response was not absent, but invisible because of a simultaneous anti-DTH response," explained Charles G. Orosz, professor of surgery and a co-author of the study. "Also, that this downregulation of DTH was linked to the donor antigen, and was dependent on either TGF-B or IL-10."

In addition to the three cases at the heart of the study, the scientists observed the regulatory mechanism in four other patients still on immunosuppression. "We need to study this further to see how common the mechanism is, when it arises, and if patients who have this mechanism while they are taking immunosuppression would retain their transplant functions if they went off medication," VanBuskirk said.


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Contact: Anne M. VanBuskirk
Vanbuskirk.1@osu.edu
614-292-6774
Ohio State University
9-Sep-2000


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