HOME >> MEDICINE >> NEWS
Medical molecules designed to respond to visible light that can penetrate tissue

Blacksburg, Va. -- If you have ever covered a flashlight with your hand and seen the red light that still comes through, then you have seen light in the therapeutic window that magic wavelength that is not absorbed or reflected away by tissue. Scientists believe that they can use light at that wavelength to signal manmade molecules to release drugs at disease sites in the body.

Such possibilities will be discussed in a poster and a talk by Virginia Tech researchers presenting at the 229th American Chemical Society national meeting in San Diego on March 13-17.

Researchers in Karen Brewer's group at Virginia Tech have designed supramolecular complexes that can hold and, when signaled by light (photoinitiatied), will generate pharmaceutical compounds that can cleave DNA, such as in a tumor cell. "The challenge has been that tissue blocks light so we can't signal molecules deep within the body to deliver drug therapy," says Brewer, associate professor of chemistry.

Matthew Mongelli of Maywood N.J., a postdoctoral associate in chemistry, and his colleagues in chemistry and biology at Virginia Tech, have been working with Theralase Technologies Inc. to design molecular systems that use light that is in the therapeutic window. Starting with a complex with known DNA cleaving qualities, they changed the light absorber unit to one that responds to the red wavelength.

"Investigations into polyazine supermolecular complexes containing Ru and Os with Rh centers that possess photoactive MMCT states: Visible light induced, oxygen independent DNA photocleavage (INOR 329)," will be presented by Mongelli during the general poster session, 7 to 9 p.m., Sunday, March 13, in Convention Center Hall D. The poster has also been selected for the Sci_Mix session 7 to 9 p.m. Monday, March 14, in the Convention Center's Sails Pavilion.

Co-authors are Brewer; undergraduate chemistry students Matthew Jeletic of Centreville, Va. and Jerita Dubash of Ashbur
'"/>

Contact: Susan Trulove
STrulove@vt.edu
540-231-5646
Virginia Tech
13-Mar-2005


Page: 1 2

Related medicine news :

1. Medically supervised drug injection facilities safer for users
2. Philanthropist Paul F. Glenn launches labs for aging research at Harvard Medical School
3. UCLA Medical Center becomes first hospital to introduce remote presence robots in ICU
4. New data on Orqis Medicals Cancion CRS to be reported at ACC
5. Medical technologies may hinder rather than help newborn survival
6. Medical meeting to feature research findings and disease prevention and health promotion sessions
7. LA BioMed Medical/Research briefs January 2005
8. Medical negligence system is secretive, unaccountable and unregulated
9. Dartmouth Medical School receives $1.6 million in AIDS funding
10. LA BioMed Medical/Research Briefs December 2004
11. Rush University Medical Center testing magnetic stimulation for depression

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/24/2018)... ... September 24, 2018 , ... As a leader in providing ... patients, clients, and students improve their movement or mobility and strength and live their ... OS Instructor status. Mike is a Coach/Instructor at Tucson Strength located in ...
(Date:9/24/2018)... ... ... The National Pediatric Cancer Foundation – the top-rated cancer charity according to ... Cancer Awareness Month. Every day, 43 children are diagnosed with cancer and 43 families ... death by disease among children, yet only 4% of the billions of dollars spent ...
(Date:9/24/2018)... WORCESTER, Mass. (PRWEB) , ... September 24, 2018 ... ... Americans virtually always have with them may become an early warning system for ... by a team of computer scientists at Worcester Polytechnic Institute (WPI). The researchers ...
(Date:9/22/2018)... ... ... From 1991 to 2012, Works of Heart raised more than one million ... to the generous artists, sponsors, and patrons who supported what became the Triangle’s premier ... HIV/AIDS, about the Alliance of AIDS Services - Carolina, and (now) about Works of ...
(Date:9/22/2018)... Fla. (PRWEB) , ... September 21, 2018 , ... Located ... Hospice will open its new inpatient hospice unit on Monday, October 1. The 8,500 ... County. , “We are excited to partner with an organization like TGH that ...
Breaking Medicine News(10 mins):
(Date:9/15/2018)... ... September 14, 2018 , ... ... individuals and families affected by Hurricane Florence. , Throughout the month of September, ... in any amount, or round up their transaction to the nearest dollar to ...
(Date:9/13/2018)... ... , ... Dr. Rod J. Rohrich is pleased to announce that registration is ... experts from around the world, will take place from March 22nd and 23rd, 2019. ... anatomy to complex surgical procedures and detailed analysis of revision rhinoplasty . Formats ...
(Date:9/13/2018)... ... September 13, 2018 , ... ... focused on developing and commercializing gastrointestinal therapeutics, has secured acceptance of Camligo™ ... Food and Drug Administration (FDA) and European Medicines Agency (EMA), have accepted ...
Breaking Medicine Technology:
Cached News: