ne is effective in treating children with severe conduct problems. The 118 children participating in this trial were those with "disruptive behavior disorders" characterized by a chronic pattern of anti-social, maladaptive behavior that often involves impulsive aggression against property, people or animals; deceitfulness; and, sometimes, violation of laws. Participants who took risperidone showed substantial reductions in symptoms of aggression, tantrums and property destruction.

Aman and his Nisonger Center colleagues Arnold, Ronald Lindsay and Yaser Ramadan now are seeking participants for new research on hyperactivity in children with autism, and will participate in an upcoming multisite study of combined risperidone and behavior therapies for treatment of autism.

An estimated 20 children in 10,000 are affected by autism. Aman said individuals with autism are described as an "orphan" population because their relatively small number has resulted in little research being conducted in the past on the disorder. However, significant government support for autism research is helping to end those years of neglect, he said.

"The National Institute of Mental Health has identified autism as a significant child and adolescent condition that needs attention and has put significant support behind it," Aman said. "This is particularly meaningful for families living with children who have this condition."

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Contact: Emily Caldwell
Caldwell.151@osu.edu
614-293-3737
Ohio State University Medical Center
31-Jul-2002

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