HOME >> MEDICINE >> NEWS
Memorial Sloan-Kettering scientists uncover function of BRCA2 protein

NEW YORK, September 13, 2002 -- Structural biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have discovered the function of the protein BRCA2. Mutations in the BRCA2 gene have been linked to hereditary breast and ovarian cancers. The results were reported in the September 13 issue of Science.

BRCA2 was already known to be a tumor suppressor -- a protective protein that prevents the development of cancer -- but exactly how the protein does its job was not understood. Now MSKCC scientists have been able to map out the structure of the protein, showing that it interacts directly with DNA and helps to repair genetic damage. An inability to correct genetic damage leads to unstable chromosomes and often to cancer.

"If BRCA2 is altered or missing, it leads to a dangerous accumulation of genetic errors," said the study's senior author Nikola P. Pavletich, PhD, head of MSKCC's Laboratory of Structural Biology of Oncogenes and Tumor Suppressors and an investigator in the Howard Hughes Medical Institute. "By studying the normal function of BRCA2, we can understand how changes in the protein contribute to the development of cancer."

BRCA2 is an unusually large molecule, which has made it difficult for researchers to study. But Dr. Pavletich's team, including first author Haijuan Yang, found a way around that problem and was able to crystallize the protein. Those crystals were then bombarded with high-energy X-rays, a process called X-ray crystallography, and the diffraction patterns created by the X-rays were used to calculate the three-dimensional picture of the protein. This picture revealed that BRCA2 is similar in structure to other proteins known to bind DNA. The researchers then took the work a step further, showing that BRCA2 does indeed bind to DNA in special regions that are commonly found around broken DNA strands.

Researchers showed that BRCA2 participates in the repair of "double-strand" breaks: These breaks are a particularl
'"/>

Contact: Christine Hickey
Hickey1@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
12-Sep-2002


Page: 1 2

Related medicine news :

1. 2005 H. Trendley Dean Memorial Award
2. Northwestern Memorial Hospital honored with one of the nations top awards for quality
3. Northwestern Memorial physicians encourage screenings during colon cancer awareness month
4. Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
5. Northwestern Memorial chosen to be featured in first-ever mini-med school TV airing on PBS
6. Countrys first simplified maze using new ultrasound technology is done at Northwestern Memorial
7. Northwestern Memorial Hospital testing new procedure for patients with major depression
8. Northwestern Memorial named one of nations top 12 hospital-affiliated infertility clinics
9. Medical College of Georgia to establish clinical campus at Phoebe Putney Memorial Hospital
10. Peter H. Arger, MD, receives the 2004 AIUM William J. Fry Memorial Lecture Award
11. Northwestern Memorial tests pacemaker for stomach

Post Your Comments:
(Date:1/22/2015)... AngelWeddingDress, the premier women’s dress supplier, has recently released ... website of AngelWeddingDress.com to find more details. , ... for a bridal party. AngelWeddingDress offers a variety of ... maternity wedding dresses are specially designed for 2015. , ...
(Date:1/22/2015)... New York (PRWEB) January 22, 2015 ... after Fresenius Medical Care recalled its GranuFlo and NaturaLyte ... multidistrict litigation underway in U.S. District Court, District of ... dated January 20th, the Court has remanded a case ...
(Date:1/22/2015)... NJ (PRWEB) January 22, 2015 Joan ... and keynote speaker at the upcoming 32nd Annual ... ACCME-accredited Physicians’ Education Resource®, LLC (PER®) , shares ... would have gone undetected if she had not followed ...
(Date:1/22/2015)... 22, 2015 IsoComforter, Inc. has introduced the ... patented IsoTube design to treat specific body parts and muscle ... progressive and easy to use patented cold therapy machine with ... related orthopedic and muscle injuries. IsoComforter has become the ...
(Date:1/22/2015)... As interest in the value of spiritual support as ... Rev. Eric J. Hall , president and CEO of the ... the keynote speaker on January 27 at an international summit ... The conference, “Hope and Resilience: Innovative and Interdisciplinary Spiritual Care,” ...
Breaking Medicine News(10 mins):Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 2Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 3Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 4Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 5Health News:Joan Lunden Reveals Diagnostic Approach That Led To Early Detection;To Keynote 32nd Annual Miami Breast Cancer Conference® 6Health News:IsoComforter Introduces Best of Class Cold Therapy Product to the Worldwide Market 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 2Health News:HealthCare Chaplaincy CEO to Keynote Spiritual Care Summit in Israel 3
(Date:1/23/2015)... 2015 Research and Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ) ... Market (Indwelling or Foley Catheters, Intermittent Catheters and Male ... Share, Growth, Trends and Forecast 2014 - 2020" ... present, the global market for urinary catheters is experiencing ...
(Date:1/23/2015)... WYNNEWOOD, Pa. , Jan. 23, 2015  MedScope ( ... has been nominated for a 2015 Connected World ... Personal Emergency Response System (mPERS), that can be used ... M2M technology partner.  In nominating MedScope, ...
(Date:1/23/2015)... Jan. 23, 2015  Pete Rose, baseball,s all-time hits leader, is ... pain reliever Myoflex, Ducere Pharma has announced. "Pete,s ... excited to have him on board with Myoflex," said Ducere ... a legendary player who is known across all generations. The ...
Breaking Medicine Technology:Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3MedScope Nominated by RacoWireless for Prestigious 2015 Connected World Magazine Connected World Award 2Pete Rose bets on Myoflex to relieve aches and pains 2
Cached News: