HOME >> MEDICINE >> NEWS
Memorial Sloan-Kettering scientists uncover function of BRCA2 protein

NEW YORK, September 13, 2002 -- Structural biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have discovered the function of the protein BRCA2. Mutations in the BRCA2 gene have been linked to hereditary breast and ovarian cancers. The results were reported in the September 13 issue of Science.

BRCA2 was already known to be a tumor suppressor -- a protective protein that prevents the development of cancer -- but exactly how the protein does its job was not understood. Now MSKCC scientists have been able to map out the structure of the protein, showing that it interacts directly with DNA and helps to repair genetic damage. An inability to correct genetic damage leads to unstable chromosomes and often to cancer.

"If BRCA2 is altered or missing, it leads to a dangerous accumulation of genetic errors," said the study's senior author Nikola P. Pavletich, PhD, head of MSKCC's Laboratory of Structural Biology of Oncogenes and Tumor Suppressors and an investigator in the Howard Hughes Medical Institute. "By studying the normal function of BRCA2, we can understand how changes in the protein contribute to the development of cancer."

BRCA2 is an unusually large molecule, which has made it difficult for researchers to study. But Dr. Pavletich's team, including first author Haijuan Yang, found a way around that problem and was able to crystallize the protein. Those crystals were then bombarded with high-energy X-rays, a process called X-ray crystallography, and the diffraction patterns created by the X-rays were used to calculate the three-dimensional picture of the protein. This picture revealed that BRCA2 is similar in structure to other proteins known to bind DNA. The researchers then took the work a step further, showing that BRCA2 does indeed bind to DNA in special regions that are commonly found around broken DNA strands.

Researchers showed that BRCA2 participates in the repair of "double-strand" breaks: These breaks are a particularl
'"/>

Contact: Christine Hickey
Hickey1@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
12-Sep-2002


Page: 1 2

Related medicine news :

1. 2005 H. Trendley Dean Memorial Award
2. Northwestern Memorial Hospital honored with one of the nations top awards for quality
3. Northwestern Memorial physicians encourage screenings during colon cancer awareness month
4. Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
5. Northwestern Memorial chosen to be featured in first-ever mini-med school TV airing on PBS
6. Countrys first simplified maze using new ultrasound technology is done at Northwestern Memorial
7. Northwestern Memorial Hospital testing new procedure for patients with major depression
8. Northwestern Memorial named one of nations top 12 hospital-affiliated infertility clinics
9. Medical College of Georgia to establish clinical campus at Phoebe Putney Memorial Hospital
10. Peter H. Arger, MD, receives the 2004 AIUM William J. Fry Memorial Lecture Award
11. Northwestern Memorial tests pacemaker for stomach

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:3/23/2017)... ... March 23, 2017 , ... The IoT (Internet of Things) is revolutionizing ... a huge impact on businesses and individual consumers alike. Laboratories can maximize their ... a value anywhere from $4 trillion to $11 trillion dollars by the year 2025. ...
(Date:3/23/2017)... ... March 23, 2017 , ... March is National Kidney Month – ... when it comes to maintaining good health. Every day, two kidneys filter about 120 ... every drop of your blood, eliminating waste, regulating fluid levels and blood pressure, supporting ...
(Date:3/23/2017)... ... 2017 , ... The Wound Certification Prep Course (WCPC) ... LLC, today announced that RestorixHealth® has officially endorsed WCPC as its ... in becoming Certified Wound Specialist Physicians (CWSP®). , This collaborative effort with ...
(Date:3/23/2017)... ... 2017 , ... After raising more than $1.135 million ($1,479,231 AUD) from nearly ... in crowdfunding history, has established a U.S. Headquarters in New York City, FaceCradle ... , “We’re excited to be operating on U.S. shores, where most of our initial ...
(Date:3/23/2017)... ... March 23, 2017 , ... Sharon Kleyne, host of the nationally syndicated radio ... on VoiceAmerica, recently talked on her program about how she is looking forward to ... listeners of an important distinction. World Water Day, Kleyne pointed out, is an occasion ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... The key factors driving the growth of dialysis ... growth and increasing healthcare expenditure. Some of the noteworthy trends ... ESRD patients, rising demand for home PD treatment and huge ... market is hindered by high treatment costs and stringent regulations. ... Complete ...
(Date:3/23/2017)... , March 23, 2017 As a ... along with the prevalence of allergic diseases, cutting ... are currently revolutionising the ways in which pharmaceutical ... Allergies 2017 promises to be both a high ... the allergy interest groups, immunologists, research scholars and ...
(Date:3/23/2017)... , March 23, 2017  Digital Pharmacist ... ), a rapidly growing digital health company, ... mobile app that allows patients to manage their ... locations such as Denver Health Pharmacy, USave Pharmacy ... acquisition helps Digital Pharmacist accelerate its product development ...
Breaking Medicine Technology:
Cached News: