HOME >> MEDICINE >> NEWS
Memorial Sloan-Kettering scientists uncover function of BRCA2 protein

NEW YORK, September 13, 2002 -- Structural biologists at Memorial Sloan-Kettering Cancer Center (MSKCC) have discovered the function of the protein BRCA2. Mutations in the BRCA2 gene have been linked to hereditary breast and ovarian cancers. The results were reported in the September 13 issue of Science.

BRCA2 was already known to be a tumor suppressor -- a protective protein that prevents the development of cancer -- but exactly how the protein does its job was not understood. Now MSKCC scientists have been able to map out the structure of the protein, showing that it interacts directly with DNA and helps to repair genetic damage. An inability to correct genetic damage leads to unstable chromosomes and often to cancer.

"If BRCA2 is altered or missing, it leads to a dangerous accumulation of genetic errors," said the study's senior author Nikola P. Pavletich, PhD, head of MSKCC's Laboratory of Structural Biology of Oncogenes and Tumor Suppressors and an investigator in the Howard Hughes Medical Institute. "By studying the normal function of BRCA2, we can understand how changes in the protein contribute to the development of cancer."

BRCA2 is an unusually large molecule, which has made it difficult for researchers to study. But Dr. Pavletich's team, including first author Haijuan Yang, found a way around that problem and was able to crystallize the protein. Those crystals were then bombarded with high-energy X-rays, a process called X-ray crystallography, and the diffraction patterns created by the X-rays were used to calculate the three-dimensional picture of the protein. This picture revealed that BRCA2 is similar in structure to other proteins known to bind DNA. The researchers then took the work a step further, showing that BRCA2 does indeed bind to DNA in special regions that are commonly found around broken DNA strands.

Researchers showed that BRCA2 participates in the repair of "double-strand" breaks: These breaks are a particularl
'"/>

Contact: Christine Hickey
Hickey1@mskcc.org
212-639-3573
Memorial Sloan-Kettering Cancer Center
12-Sep-2002


Page: 1 2

Related medicine news :

1. 2005 H. Trendley Dean Memorial Award
2. Northwestern Memorial Hospital honored with one of the nations top awards for quality
3. Northwestern Memorial physicians encourage screenings during colon cancer awareness month
4. Northwestern Memorial Hospital receives $10 million commitment to support preeminent heart program
5. Northwestern Memorial chosen to be featured in first-ever mini-med school TV airing on PBS
6. Countrys first simplified maze using new ultrasound technology is done at Northwestern Memorial
7. Northwestern Memorial Hospital testing new procedure for patients with major depression
8. Northwestern Memorial named one of nations top 12 hospital-affiliated infertility clinics
9. Medical College of Georgia to establish clinical campus at Phoebe Putney Memorial Hospital
10. Peter H. Arger, MD, receives the 2004 AIUM William J. Fry Memorial Lecture Award
11. Northwestern Memorial tests pacemaker for stomach

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/28/2016)... California (PRWEB) , ... May 28, 2016 , ... "Color ... to drag and drop a preset onto their media," said Christina Austin - CEO ... Film Studios, editors can quickly and easily add stylish color grades to their footage. ...
(Date:5/27/2016)... ... ... Southland Log Homes , designer and manufacturer of America’s Favorite Log Home™, ... found on its website at SouthlandLogHomes.com. , The designs of the wood barn ... of timber post and beam construction. The result is a barn that not ...
(Date:5/27/2016)... ... May 27, 2016 , ... This campaign aims to provide a ... as a society can control and change. , As nearly 795,000 Americans suffering from ... within the United States. Plus, with an estimated 129,000 of these people dying from ...
(Date:5/27/2016)... York, NY (PRWEB) , ... May 27, 2016 , ... ... by inspiring human interest stories, which come courtesy of leaders in the nursing and ... the industry, from leading advocates and associations—namely Abilene Christian University. , As the ...
(Date:5/26/2016)... Gilsum, New Hampshire (PRWEB) , ... May 26, 2016 , ... ... natural skin care products, has been honored with a 2016 When Work Works Award ... This prestigious award, part of the national When Work Works project administered by the ...
Breaking Medicine News(10 mins):
(Date:5/27/2016)... , May 27, 2016 ... biopharmaceutical company focused on late-stage drug development, today ... Pharma of pivotal batches required for registration ... Administration (FDA). This follows Kitov,s announcement ... trial successfully met its primary efficacy endpoint. ...
(Date:5/26/2016)... , May 26, 2016 According ... "Medical Waste Management Market - U.S. Industry Analysis, Size, Share, ... management market in the U.S. was valued at US$ 5.89 ... CAGR of 3.4% from 2015 to 2023 to reach US$ ... analysis of current and emerging needle free drug delivery devices ...
(Date:5/26/2016)... 26, 2016   Change Healthcare , ... network solutions and technology-enabled services designed to ... into a strategic channel partnership with SourceMed, ... solutions and revenue cycle management services that ... rehabilitation clinics to optimize revenue, operational efficiency ...
Breaking Medicine Technology:
Cached News: