HOME >> MEDICINE >> NEWS
Mice lacking fat-making enzyme are leaner, more sensitive to leptin and insulin

A modern-day Rip van Winkle, just emerging from his long sleep, might notice a difference in todays Americans. The average American is much rounder, plumper, and heavier.

Obesity has been on the rise for the past two decades. The problem has now reached epidemic proportions, with more than 50 percent of the American population now classified as overweight or obese. While government-sponsored agencies try to spread the gospel of good eating and regular exercise, more and more Americans are finding that their clothes fit tighter every day. And no effective medical therapies currently exist for people with morbid obesity.

Whats the solution? Certainly not the miracle elixirs touted to melt away the pounds in a matter of weeks. The ultimate solution would be a way to stop the body from making fat. Sound like science fiction? Not to researchers at the Gladstone Institute of Cardiovascular Disease.

Theyve found a group of genes for an enzyme called DGAT (also called diacylglycerol acyltransferase). In animals, DGAT is essential for the last step in the production of triglycerides, the major component of fat. Mice that lack one of the DGAT enzymes, DGAT1, are leaner than mice with normal amounts of DGAT1and twice as activedespite their high-fat diets. Put simply, without DGAT1, the mice werent able to become obese.

Now the researchers have found a potential mechanism for this obesity resistance. They found that DGAT1-deficient mice are more sensitive to leptin, the hormone that tells the brain when the body has had enough to eat and encourages energy expenditure. They also found that these mice are more sensitive to insulin, and therefore potentially less likely to develop diabetes. The new findings are published in the April 15 issue of the Journal of Clinical Investigation.

This is good news. Obese and overweight people tend to develop type 2 diabetes, or insulin-resistant diabetes, because their cells become deaf to insulins
'"/>

Contact: Laura Lane
llane@gladstone.ucsf.edu
415-695-3833
University of California - San Francisco
10-Apr-2002


Page: 1 2 3

Related medicine news :

1. Teenage girls lacking in vitamin D
2. Emotion-regulating protein lacking in panic disorder
3. Guidelines lacking for patients hospitalized for heart failure
4. Evidence of PSA screening efficacy lacking
5. Women find physician guidelines on estrogen replacement therapy are lacking
6. Scientists discover enzyme crucial to the transportation of proteins within cells
7. Scientists discover enzyme crucial to HIV replication
8. Study shows coenzyme Q10 may prevent migraine
9. New information about heart enzymes could lead to better treatments
10. Researchers identify enzyme that may turn fleeting experience into lasting memory
11. Scientists identify novel enzyme with key role in leukemia proteins normal function

Post Your Comments:
(Date:12/17/2014)... -- Expectant parents should leave prenatal picture-taking to medical ... Use of ultrasound imaging and heartbeat monitors to get ... agency warns. "Although there is a lack ... and heartbeat monitors, prudent use of these devices by ... FDA biomedical engineer, said in an agency news release. ...
(Date:12/17/2014)... HealthDay Reporter , TUESDAY, Dec. 16, ... America, and work commitment is a big reason why, new ... said Dr. Mathias Basner, an assistant professor of sleep and ... of Medicine. A time-use survey of nearly 125,000 Americans, ... main activity exchanged for sleep. Short sleepers -- those who ...
(Date:12/15/2014)... 15, 2014 South Florida’s leading urgent care ... can be a daze of hassle, hustle, and bustle that ... decking halls, to burns when making special meals and heartburn ... can happen at any time. To prevent this season of ... made a list of helpful and healthful holiday tips to ...
(Date:12/15/2014)... News) -- Expert pilots process visual information more efficiently ... better decisions during landings, a new study shows. ... pilots to master, and 36 percent of all airplane ... final approach and landing. Researchers monitored the brain ... pilots while they were at the controls of a ...
(Date:12/15/2014)... 15, 2014 At the leading, long-established ... AutismOne and Focus Autism will welcome ... research on the effects of toxins to children’s health, ... information. , Luminaries such as Dr. Lucija Tomljenovic ... with esteemed, credentialed colleagues of the United States to ...
Breaking Medicine News(10 mins):Health News:FDA Warns Against Fetal 'Keepsake' Videos 2Health News:Work Steals Valuable Sleep Time, Study Finds 2Health News:Work Steals Valuable Sleep Time, Study Finds 3Health News:MD Now Urgent Care Presents Healthy Holiday Tips 2Health News:MD Now Urgent Care Presents Healthy Holiday Tips 3Health News:Study Shows Why Expert Pilots Are Experts 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 2Health News:AutismOne and Focus Autism Collaborate on Scientific Conference; International Group of Researchers to Present in Chicago, May 2015 3
(Date:12/17/2014)... , Dec. 17, 2014  Beamz Interactive, ... interactive music products, today announced that it has ... leading manufacturer and supplier of innovative prosthetic, orthotic ... As part of the agreement, RSL Steeper will ... solution specifically configured for use within UK residential ...
(Date:12/17/2014)... ANGELES , Dec. 17, 2014  ImmunoCellular ... the US Patent and Trademark Office (USPTO) has ... ICT-107, a dendritic cell-based immunotherapeutic vaccine targeting six ... The claims of US Patent No. 8,871,211, which ... neural cancer by administering a dendritic cell composition ...
(Date:12/17/2014)... Mass. , Dec. 17, 2014  RXi ... biotechnology company focused on discovering, developing and commercializing ... RNA-targeted technologies, today announced completion of enrollment in its ... from the 3-month observations confirmed the 1-month findings ... Logo - http://photos.prnewswire.com/prnh/20130917/NE80755LOGO ...
Breaking Medicine Technology:Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 2Beamz Interactive, Inc. Signs UK Distribution Agreement with RSL Steeper Limited 3ImmunoCellular Therapeutics Announces Issuance of Key Patent For ICT-107 Cancer Vaccine 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 2RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 3RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 4RXi Pharmaceuticals Announces Sustained Effect of RXI-109 at Three Months Post Scar Revision Surgery and the Completion of Enrollment for its Phase 2a Trial RXI-109-1301 5
Cached News: