HOME >> MEDICINE >> NEWS
Mice lacking fat-making enzyme are leaner, more sensitive to leptin and insulin

A modern-day Rip van Winkle, just emerging from his long sleep, might notice a difference in todays Americans. The average American is much rounder, plumper, and heavier.

Obesity has been on the rise for the past two decades. The problem has now reached epidemic proportions, with more than 50 percent of the American population now classified as overweight or obese. While government-sponsored agencies try to spread the gospel of good eating and regular exercise, more and more Americans are finding that their clothes fit tighter every day. And no effective medical therapies currently exist for people with morbid obesity.

Whats the solution? Certainly not the miracle elixirs touted to melt away the pounds in a matter of weeks. The ultimate solution would be a way to stop the body from making fat. Sound like science fiction? Not to researchers at the Gladstone Institute of Cardiovascular Disease.

Theyve found a group of genes for an enzyme called DGAT (also called diacylglycerol acyltransferase). In animals, DGAT is essential for the last step in the production of triglycerides, the major component of fat. Mice that lack one of the DGAT enzymes, DGAT1, are leaner than mice with normal amounts of DGAT1and twice as activedespite their high-fat diets. Put simply, without DGAT1, the mice werent able to become obese.

Now the researchers have found a potential mechanism for this obesity resistance. They found that DGAT1-deficient mice are more sensitive to leptin, the hormone that tells the brain when the body has had enough to eat and encourages energy expenditure. They also found that these mice are more sensitive to insulin, and therefore potentially less likely to develop diabetes. The new findings are published in the April 15 issue of the Journal of Clinical Investigation.

This is good news. Obese and overweight people tend to develop type 2 diabetes, or insulin-resistant diabetes, because their cells become deaf to insulins
'"/>

Contact: Laura Lane
llane@gladstone.ucsf.edu
415-695-3833
University of California - San Francisco
10-Apr-2002


Page: 1 2 3

Related medicine news :

1. Teenage girls lacking in vitamin D
2. Emotion-regulating protein lacking in panic disorder
3. Guidelines lacking for patients hospitalized for heart failure
4. Evidence of PSA screening efficacy lacking
5. Women find physician guidelines on estrogen replacement therapy are lacking
6. Scientists discover enzyme crucial to the transportation of proteins within cells
7. Scientists discover enzyme crucial to HIV replication
8. Study shows coenzyme Q10 may prevent migraine
9. New information about heart enzymes could lead to better treatments
10. Researchers identify enzyme that may turn fleeting experience into lasting memory
11. Scientists identify novel enzyme with key role in leukemia proteins normal function

Post Your Comments:
(Date:4/17/2014)... April 17, 2014 By discovering a new mechanism ... a stroke, researchers at UC Irvine and the Salk ... may limit or prevent stroke-induced brain damage. , A ... cause of death and primary reason for disability in ... a stroke and lets blood-borne material into the brain, ...
(Date:4/17/2014)... EcoHealth Alliance, a nonprofit organization that focuses on conservation ... today examining the current state of knowledge of the ... improved global surveillance strategies to combat the emergence of ... in West Africa that has claimed the lives of ... According to the World Health Organization (WHO), the ...
(Date:4/17/2014)... has the potential to ward off depression among retirees, ... published online in The Journals of Gerontology, ... In the article " Internet Use and Depression Among ... Analysis ," the authors report that Internet use reduced ... among their study sample. , Late-life depression affects ...
(Date:4/17/2014)... and their partners have found that their proprietary microbicide ... of multiple sexually transmitted infections (STIs) in both the ... 2 (HSV-2), and human papillomavirus (HPV). The USAID-funded study ... effective against multiple strains of HIV, and has a ... viruses of at least eight hours prior to exposure. ...
(Date:4/17/2014)... N.C. April 17, 2014 Meaningful long-term ... advanced cancer of the abdomen when treated with ... according to a first-of-its-size analysis by physicians at ... Baptist has the largest reported, single-center experience with ... A. Levine, M.D., and analysis of 20 years, ...
Breaking Medicine News(10 mins):Health News:Study IDs new cause of brain bleeding immediately after stroke 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 2Health News:Re-emergence of Ebola focuses need for global surveillance strategies 3Health News:Internet use may cut retirees' depression 2Health News:Animal study provides first evidence that gel can prevent multiple virus transmission in vagina/rectum 2Health News:20 years of data shows treatment technique improvement for advanced abdominal cancer 2
(Date:1/15/2014)... , Jan. 15, 2014 The Cadence Fitness ... Fitness Center by the Medical Fitness Association, a non-profit ... achieve their full potential. The Cadence Fitness & Health ... western suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... & Forecast – Worldwide Analysis ... Pump Market Analysis ...
(Date:1/15/2014)... 15, 2014  Valeant Pharmaceuticals International, Inc. (NYSE: ... waiting period under the Hart-Scott-Rodino Antitrust Improvements Act of ... offer by its indirect wholly-owned subsidiary, Sapphire Subsidiary Corp. ... stock of Solta Medical, Inc. (NASDAQ: SLTM ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
Cached News: