HOME >> MEDICINE >> NEWS
Mice lacking fat-making enzyme are leaner, more sensitive to leptin and insulin

A modern-day Rip van Winkle, just emerging from his long sleep, might notice a difference in todays Americans. The average American is much rounder, plumper, and heavier.

Obesity has been on the rise for the past two decades. The problem has now reached epidemic proportions, with more than 50 percent of the American population now classified as overweight or obese. While government-sponsored agencies try to spread the gospel of good eating and regular exercise, more and more Americans are finding that their clothes fit tighter every day. And no effective medical therapies currently exist for people with morbid obesity.

Whats the solution? Certainly not the miracle elixirs touted to melt away the pounds in a matter of weeks. The ultimate solution would be a way to stop the body from making fat. Sound like science fiction? Not to researchers at the Gladstone Institute of Cardiovascular Disease.

Theyve found a group of genes for an enzyme called DGAT (also called diacylglycerol acyltransferase). In animals, DGAT is essential for the last step in the production of triglycerides, the major component of fat. Mice that lack one of the DGAT enzymes, DGAT1, are leaner than mice with normal amounts of DGAT1and twice as activedespite their high-fat diets. Put simply, without DGAT1, the mice werent able to become obese.

Now the researchers have found a potential mechanism for this obesity resistance. They found that DGAT1-deficient mice are more sensitive to leptin, the hormone that tells the brain when the body has had enough to eat and encourages energy expenditure. They also found that these mice are more sensitive to insulin, and therefore potentially less likely to develop diabetes. The new findings are published in the April 15 issue of the Journal of Clinical Investigation.

This is good news. Obese and overweight people tend to develop type 2 diabetes, or insulin-resistant diabetes, because their cells become deaf to insulins
'"/>

Contact: Laura Lane
llane@gladstone.ucsf.edu
415-695-3833
University of California - San Francisco
10-Apr-2002


Page: 1 2 3

Related medicine news :

1. Teenage girls lacking in vitamin D
2. Emotion-regulating protein lacking in panic disorder
3. Guidelines lacking for patients hospitalized for heart failure
4. Evidence of PSA screening efficacy lacking
5. Women find physician guidelines on estrogen replacement therapy are lacking
6. Scientists discover enzyme crucial to the transportation of proteins within cells
7. Scientists discover enzyme crucial to HIV replication
8. Study shows coenzyme Q10 may prevent migraine
9. New information about heart enzymes could lead to better treatments
10. Researchers identify enzyme that may turn fleeting experience into lasting memory
11. Scientists identify novel enzyme with key role in leukemia proteins normal function

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to ... to save lost souls in the Philippines. “The Journey: From the Mountains to the ... teacher of the Bible. She has taught all ages and currently teaches a class ...
(Date:10/12/2017)... ... October 12, 2017 , ... The company ... of today’s consumer and regulatory authorities worldwide. From Children’s to Adults 50+, every ... meet the highest standard. , These products are also: Gluten Free, Non-GMO, ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... ... Mohebi Hair Restoration, has recently contributed a medical article to the newly revamped ... cosmetictown.com. Dr. Mohebi’s article spotlights the hair transplant procedure known as Follicular ...
(Date:10/12/2017)... ... October 12, 2017 , ... Health Literacy ... health literacy software tool, and the Cancer Patient Education Network (CPEN), an independent ... today announce a new strategic alliance. , As CPEN’s strategic partner, HLI ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... , Oct. 10, 2017   West Pharmaceutical ... innovative solutions for injectable drug administration, today shared the ... ID Adapter for improving the intradermal administration of polio ... Skin Vaccination Summit in May 2017 by Dr. ... Polio Department, World Health Organization (WHO), and recently published ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
(Date:10/2/2017)... Diplomat Pharmacy, Inc. (NYSE: DPLO ... LLC , and named its founder as Diplomat,s chief ... Tennessee , will operate under Diplomat subsidiary ... offerings for health care partners to include IT outsourcing, ... "In an interoperable world, technology delivers comprehensive insight ...
Breaking Medicine Technology:
Cached News: