HOME >> MEDICINE >> NEWS
Migraine Pain: Not Mainly In The Brain

Hopkins researchers think they've found the source of pain in migraines.

The research shifts explanations away from traditional ones involving dilating or constricting blood vessels to the back of the head and focuses instead on changes within the meninges, the protective tissue layers covering the brain.

The research, which involved SPECT scans of patients in the midst of a headache, points to a surer way to diagnose debatable migraines. It also offers scientists a straightforward method to judge therapy for the common headaches that plague millions nationwide. The study was presented at this week's American Academy of Neurology meetings in Toronto by Hopkins neurologist Marco Pappagallo, M.D., who headed a research team.

Patients in the study came to Hopkins in the midst of a well-documented migraine attack and pinpointed the site of their headache on a diagram. They then received IV injection of the common blood plasma protein, albumen, tagged with a radioactive isotope.

Radiologists took SPECT (single photon emission computerized tomography) scans of the head at 10 minutes and 3 hours, and then several days later, after headaches subsided, as a baseline. During inflammation that occurs during a migraine, Pappagallo says, blood vessels in the meninges become unusually permeable to molecules such as albumen. The SPECT scans then pick up the albumen leakage into surrounding tissues.

The images showed bright, diffuse patches -- a sign of inflammation -- at areas in the meninges that precisely matched places where patients said they felt their headaches, thus linking abnormalities in the meninges with the pain.

But the inflammation itself isn't the immediate cause of migraine pain, Pappagallo adds. That, the researchers believe, comes from abnormal nerve activity. Animal studies elsewhere show that electrically stimulating the trigeminal nerve, the major nerve leading from the brain to head a
'"/>

Contact: Marjorie Centofanti
mcentofanti@jhmi.edu
410-955-8725
Johns Hopkins Medical Institutions
21-Apr-1999


Page: 1 2

Related medicine news :

1. Migraine linked to risky heart health
2. Migraine-sparked vision loss may increase stroke risk in women; Migraine
3. Migraine with aura, cholesterol increase risk of stroke in women
4. ID Migraine screener found to be highly reliable in detecting migraine in undiagnosed patients
5. Migraines cost employers millions in productivity, but interventions can help
6. Pharmacologist tip sheet: Migraine patches, nicotine therapies, allergy medication interference...
7. Anti-Migraine Drugs Might Cause More Pain Than Relief For Those With Heart Disease
8. Scientists Track Effectiveness Of Migraine Drugs With Ultrasound
9. Brain activity prior to treatment flags vulnerability to antidepressant side effects
10. Brain imaging study may hold clues to onset of schizophrenia in people at high risk
11. Brain imaging reveals secrets of love, fear and betrayal

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/16/2019)... OLATHE, Kan. (PRWEB) , ... June 15, 2019 , ... ... to traumatic experiences, poverty, untreated mental health needs and lack of a support network, ... decision is made to remove the children from the home and place them with ...
(Date:6/14/2019)... , ... June 14, 2019 , ... ... Tempur-Pedic® Mattress & Pink Bag Event® scheduled for Saturday, July 13th. UBCF is ... men and children directly impacted by breast cancer. This second event was added ...
(Date:6/13/2019)... ... 2019 , ... Endometriosis is a painful, inflammatory disease that occurs when tissue grows outside of ... , Heavy bleeding , Irregular menstruation , Severe cramps ... uses the latest and newest treatment protocols in dealing with the symptoms of endometriosis. In ...
(Date:6/13/2019)... ... June 13, 2019 , ... Charm Sciences, Inc. ... has been accepted by the 2019 National Conference of Interstate Milk Shipments for ... , The Charm BL30SEC test was validated by third party laboratories working in ...
(Date:6/13/2019)... ... 13, 2019 , ... Hard money lenders like Monroe Funding Corporation are able ... also be provided quickly. If the documentation and collateral are immediately available, it’s possible ... the federal oversight involved with a traditional lender, which allows loans to be customized ...
Breaking Medicine News(10 mins):
(Date:6/19/2019)... ... June 19, 2019 , ... ... vitro toxicology testing solutions, announced the addition of the Human MDR-1 / ... in vitro toxicology offerings and allows researchers to perform critical toxicology testing previously ...
(Date:6/18/2019)... ... June 18, 2019 , ... Officials with ... management services, are pleased to announce the acquisition of Leading Edge Medical Associates ... LEMA’s 34 physicians and 9 advanced practice clinicians care for 115,000 emergency department ...
(Date:6/16/2019)... United Kingdom (PRWEB) , ... June 15, 2019 ... ... http://www.lycote.com , has just published results of a clinical study on its new ... the company used different nutraceutical capsule and chocolate formulations, which were based on ...
Breaking Medicine Technology:
Cached News: