HOME >> MEDICINE >> NEWS
Missing proteins in the uterus tied to infertility in women with endometriosis

CHAPEL HILL, Friday, June 30, 2000 -- Proteins missing from cells lining the wombs of women with endometriosis may help explain their infertility, according to findings from a study headed by a University of North Carolina at Chapel Hill scientist.

The findings published in the July 1 issue of the medical journal Fertility and Sterility could add important clues to the link between infertility and endometriosis -- a link that has been controversial. The research suggests that the cellular proteins alphav-beta3 and leukemia inhibitory factor (LIF) may serve as biomarkers for identifying women whose infertility is linked to their endometriosis and is most likely reversible with treatment.

In endometriosis, fragments of the uterine lining -- the endometrium -- implant elsewhere in the pelvis, such as on the vagina, ovaries, cervix, bladder and rectum. The condition exists in up to 40 percent of women with infertility, but the link between minimal or mild endometriosis and infertility remains unclear. As many as half of women with endometriosis will become pregnant without any treatment for the condition. Moreover, studies on the adverse effects of endometriosis on pregnancy rates have yielded conflicting results.

The new study headed by Dr. Bruce A. Lessey, associate professor of obstetrics and gynecology at the UNC-CH School of Medicine, suggests that a reduction of the proteins in question may interfere with embryo implantation in the uterine lining. Alphav-beta3 and LIF are present in uterine cells around day 20 of the typical 28-day menstrual cycle, suggesting they play an important role in the embryo's subsequent attachment to the uterine lining.

Lessey, a member of the department's reproductive endocrinology and infertility division, had previously identified alphav-beta 3 as one of a family of "cell adhesion" glycoproteins called integrins that may be vital to pregnancy. LIF recently was shown by study co-author Dr. Colin L. Stewart t
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
29-Jun-2000


Page: 1 2 3

Related medicine news :

1. Missing signal causes misrouting in certain degenerative eye diseases
2. Doctors Missing Chance To Help Teens Who Smoke
3. Brain synapse formation linked to proteins, Stanford study finds
4. Scientists discover enzyme crucial to the transportation of proteins within cells
5. Uncoupling proteins in human heart
6. Lab studies show two proteins prevented progressive nerve cell loss in Parkinsons disease
7. Unexpected similarities between raindrops and proteins
8. Self-assembling proteins could help repair human tissue
9. New findings on nerve cell proteins show promise for reducing disability
10. C-reactive proteins do not predict early osteoarthritis
11. Two proteins may help prevent Alzheimers brain plaques

Post Your Comments:
(Date:7/25/2014)... 2014 A federal judge has denied ... DePuy Pinnacle hip lawsuits ( http://www.depuypinnacle-lawsuit.com/ ) selected ... to go before a jury on September 1, 2014, ... July 18th, U.S. District Judge Ed Kinkeade of the ... claims may proceed to trial against Johnson & Johnson, ...
(Date:7/25/2014)... (PRWEB) July 25, 2014 Ticket ... across the board for the Guinness International Champions Cup ... Olympiacos FC at Soldier Field on Sunday, July ... their customer appreciation promo/coupon/offer code SOCCER-2014 for added savings. ... year for diehard soccer fans in North America. Countless ...
(Date:7/25/2014)... Gerontological Society of America (GSA) the ... of aging has chosen Heather M. Young, ... Davis, as the 2014 recipient of the Doris ... honor, presented by GSA,s Health Sciences Section, is ... recognition of outstanding and sustained contribution to gerontological ...
(Date:7/25/2014)... Rhode Island (PRWEB) July 25, 2014 ... pleased to announce that Dr. Kerri Luzzo, Lead Physician ... Forty Award" for her professional accomplishments in fertility care ... , At the 10th Annual PBN Awards ceremony ... Rhode Island, 40 of the most highly regarded, emerging ...
(Date:7/25/2014)... 2014 The Little Gym of Houston ... Sunday, July 27 at Discovery Green in downtown Houston. ... Katy, Pearland, Friendswood, Spring, The Woodlands, Sugarland-Missouri City, Kingwood, ... , “We’re thrilled to be attending and performing at ... who owns the Sugarland-Missouri City location. “We believe in ...
Breaking Medicine News(10 mins):Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 2Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 3Health News:First Federal DePuy Pinnacle Hip Lawsuits Headed for Trial, As Judge Denies Defense Motions For Dismissal, Summary Judgment, Bernstein Liebhard LLP Reports 4Health News:Liverpool FC vs. Olympiacos FC Tickets Soldier Field: Ticket Down Slashes Ticket Prices for Guinness International Champions Cup in Chicago on Sunday, July 27th 2Health News:Young earns GSA's 2014 Doris Schwartz Gerontological Nursing Research Award 2Health News:Dr. Kerri Luzzo of the Reproductive Science Center of Providence Receives “40 Under Forty Award" for Outstanding Professional Accomplishments and Community Outreach 2Health News:The Little Gym of Houston to Attend Houston Family Magazine’s Family Fun Fest 2014 2
(Date:7/25/2014)... According to a new market ... Insulin Market (Rapid-Acting, Short-Acting, Intermediate-Acting, Long-Acting, Premixed, Modern and ... and Forecast (Value and Volume), 2013 - 2019", the ... in 2012 and is expected to grow at a ... USD 32.24 billion in 2019. Browse the ...
(Date:7/25/2014)... 25, 2014  IDEXX Laboratories, Inc. (NASDAQ: ... quarter of 2014 increased 11% versus the prior year ... for the second quarter of 2014 versus the prior ... in distributor inventory 2 . Earnings per diluted share ... 11% from the prior year period to $1.10."In the ...
(Date:7/25/2014)... 2014 Leading events organizer UBM Live ... the seventh year to São Paulo, Brazil ... 2014. The event will co-locate with Food Ingredients South America ... meeting point for the pharmaceutical industry.      (Logo: ... pharmaceutical sales are now exploring the South America ...
Breaking Medicine Technology:Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 2Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 3Global Insulin Market Expected to Reach USD 32.24 Billion Globally in 2019: Transparency Market Research 4IDEXX Laboratories Announces Second Quarter Results 2IDEXX Laboratories Announces Second Quarter Results 3IDEXX Laboratories Announces Second Quarter Results 4IDEXX Laboratories Announces Second Quarter Results 5IDEXX Laboratories Announces Second Quarter Results 6IDEXX Laboratories Announces Second Quarter Results 7IDEXX Laboratories Announces Second Quarter Results 8IDEXX Laboratories Announces Second Quarter Results 9IDEXX Laboratories Announces Second Quarter Results 10IDEXX Laboratories Announces Second Quarter Results 11IDEXX Laboratories Announces Second Quarter Results 12IDEXX Laboratories Announces Second Quarter Results 13IDEXX Laboratories Announces Second Quarter Results 14IDEXX Laboratories Announces Second Quarter Results 15IDEXX Laboratories Announces Second Quarter Results 16IDEXX Laboratories Announces Second Quarter Results 17IDEXX Laboratories Announces Second Quarter Results 18IDEXX Laboratories Announces Second Quarter Results 19IDEXX Laboratories Announces Second Quarter Results 20IDEXX Laboratories Announces Second Quarter Results 21IDEXX Laboratories Announces Second Quarter Results 22IDEXX Laboratories Announces Second Quarter Results 23IDEXX Laboratories Announces Second Quarter Results 24IDEXX Laboratories Announces Second Quarter Results 25IDEXX Laboratories Announces Second Quarter Results 26IDEXX Laboratories Announces Second Quarter Results 27IDEXX Laboratories Announces Second Quarter Results 28IDEXX Laboratories Announces Second Quarter Results 29IDEXX Laboratories Announces Second Quarter Results 30IDEXX Laboratories Announces Second Quarter Results 31IDEXX Laboratories Announces Second Quarter Results 32IDEXX Laboratories Announces Second Quarter Results 33
Cached News: