HOME >> MEDICINE >> NEWS
Missing proteins in the uterus tied to infertility in women with endometriosis

CHAPEL HILL, Friday, June 30, 2000 -- Proteins missing from cells lining the wombs of women with endometriosis may help explain their infertility, according to findings from a study headed by a University of North Carolina at Chapel Hill scientist.

The findings published in the July 1 issue of the medical journal Fertility and Sterility could add important clues to the link between infertility and endometriosis -- a link that has been controversial. The research suggests that the cellular proteins alphav-beta3 and leukemia inhibitory factor (LIF) may serve as biomarkers for identifying women whose infertility is linked to their endometriosis and is most likely reversible with treatment.

In endometriosis, fragments of the uterine lining -- the endometrium -- implant elsewhere in the pelvis, such as on the vagina, ovaries, cervix, bladder and rectum. The condition exists in up to 40 percent of women with infertility, but the link between minimal or mild endometriosis and infertility remains unclear. As many as half of women with endometriosis will become pregnant without any treatment for the condition. Moreover, studies on the adverse effects of endometriosis on pregnancy rates have yielded conflicting results.

The new study headed by Dr. Bruce A. Lessey, associate professor of obstetrics and gynecology at the UNC-CH School of Medicine, suggests that a reduction of the proteins in question may interfere with embryo implantation in the uterine lining. Alphav-beta3 and LIF are present in uterine cells around day 20 of the typical 28-day menstrual cycle, suggesting they play an important role in the embryo's subsequent attachment to the uterine lining.

Lessey, a member of the department's reproductive endocrinology and infertility division, had previously identified alphav-beta 3 as one of a family of "cell adhesion" glycoproteins called integrins that may be vital to pregnancy. LIF recently was shown by study co-author Dr. Colin L. Stewart t
'"/>

Contact: Leslie H. Lang
llang@med.unc.edu
919-843-9687
University of North Carolina School of Medicine
29-Jun-2000


Page: 1 2 3

Related medicine news :

1. Missing signal causes misrouting in certain degenerative eye diseases
2. Doctors Missing Chance To Help Teens Who Smoke
3. Brain synapse formation linked to proteins, Stanford study finds
4. Scientists discover enzyme crucial to the transportation of proteins within cells
5. Uncoupling proteins in human heart
6. Lab studies show two proteins prevented progressive nerve cell loss in Parkinsons disease
7. Unexpected similarities between raindrops and proteins
8. Self-assembling proteins could help repair human tissue
9. New findings on nerve cell proteins show promise for reducing disability
10. C-reactive proteins do not predict early osteoarthritis
11. Two proteins may help prevent Alzheimers brain plaques

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/8/2016)... (PRWEB) , ... February 08, 2016 , ... Steve Helwig ... with a vital new community enrichment program, has teamed up with Citizens Opposed to ... children suffering from intimate abuse. To support all those victimized by the fear of ...
(Date:2/8/2016)... ... February 08, 2016 , ... Remember the old saying “rub some dirt on ... A~, author of “Calcium Bentonite Clay” the health benefits of integrating clay into a ... the body. , A former motivational speaker, Perry A~ has since dedicated her life ...
(Date:2/8/2016)... Gaithersburg, MD (PRWEB) , ... February 08, 2016 ... ... (AHCC) is excited to share this important news! AHCC and the Home Health ... (AHA) Coding Clinic, CMS' designee for official ICD coding guidance and clarifications, to ...
(Date:2/8/2016)... ... February 08, 2016 , ... According to ... the U.S. require dental technicians to be certified or obtain continuing education. To ... created the “What’s In Your Mouth?” campaign to inform dentists and patients about ...
(Date:2/6/2016)... ... 06, 2016 , ... FOR INFORMATION: Gayle ... SURGICAL CONFERENCE & EXPO , WHAT:     , This conference is the largest ... nurses in attendance to study the latest evidence-based recommendations and resources for ...
Breaking Medicine News(10 mins):
(Date:2/8/2016)... , Feb. 8, 2016   GS1 US ... to guide them through GS1 Standards implementation to address ... (FDA) Unique Device Identification (UDI) rule. ... Beth Gibson , senior director industry development, medical ... development director, GS1 US --> ...
(Date:2/8/2016)... -- In a historic vote among its members this weekend, the Shinnecock ... cultivation facility and dispensary on tribal land near Southampton ... a provider for patients in the state,s Medical Cannabis Program. ... for patients in the state,s Medical Cannabis Program. --> ... and pursue designation from the State of New York ...
(Date:2/8/2016)... , Feb. 8, 2016   Intarcia Therapeutics, ... Yee , MD, MPH, into the newly created role ... and Operations. Dr. Yee has two decades of leadership ... and at a major academic medical center. Most recently ... US Diabetes, and VP, US Head Medical Officer at ...
Breaking Medicine Technology:
Cached News: