Mixed amphetamine salts significantly better than atomoxetine in treating children...( idenced by a lack of significant behavi...),Health

Attention

In addition, children's attention significantly improved over the three-week study period with mixed amphetamine salts, compared to atomoxetine and baseline (P<0.0001 for both), as measured by the SKAMP attention rating scale. Further, mixed amphetamine salts significantly and consistently improved attention scores during the day (P<0.0001 for each time measure post-dosing), helping children better concentrate throughout the 12-hour day. In contrast, atomoxetine significantly improved attention only at week one (P=0.04). Attention scores for atomoxetine also varied throughout the remainder of the study and did not achieve significance at weeks two and three or overall, compared to baseline (P=0.5, P=0.118 and P=0.084, respectively).

Academic Productivity

Mixed amphetamine salts significantly improved children's academic productivity compared to atomoxetine, specifically, their ability to complete more math problems and complete them correctly. These math tests were a secondary efficacy assessment of the trial, as measured by the Permanent Product Measure of Performance (PERMP). The PERMP is a 10-minute, age-adjusted collection of math problems, which provides an accurate measure of a child's ability to pay attention and stay on task correlated by an increase in number of successfully completed problems. Overall, when considering baseline productivity, children taking mixed amphetamine salts attempted more than twice the number of additional problems attempted by patients taking atomoxetine (P<0.0001) over the three-week study. Likewise, the children taking mixed amphetamine salts correctly answered more than twice the number of additional problems than the patients taking atomo
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Contact: Tom Vasich
tmvasich@uci.edu
949-824-6922
Porter Novelli
4-May-2004