HOME >> MEDICINE >> NEWS
Molecular architects create new cancer preventives

Researchers at The Johns Hopkins University have developed a modified form of vitamin D and determined that it helps delay the onset and reduce the number of skin cancers in lab mice. Unlike vitamin D, though, the new compound does not cause calcium to seep from the bones.

If not for the calcium loss problem, large doses of vitamin D could be used to reduce the odds of developing cancer in patients whose medical history, genetic heritage, or environmental exposures put them at increased risk. Depending on the results of further tests in animals and potential tests in humans, the new compound and others to follow it may provide an important alternative approach to reducing cancer risk for such patients.

Gary Posner, Scowe Professor of Chemistry in Johns Hopkins' Krieger School of Arts and Sciences and one of the new compound's creators, will describe work to design and test the compounds at a meeting of the American Chemical Society in Washington, D.C., this week.

In the July/August issue of "Carcinogenesis," Posner and Thomas Kensler, professor at the Johns Hopkins School of Public Health, published results of tests in mice of four modified forms of vitamin D, called deltanoids or vitamin D analogs. The deltanoids were applied to the skin of mice also treated with a carcinogen.

All four deltanoids diminished the number of skin tumors without any significant effects on calcium loss or weight gain, which is usually adversely affected by vitamin D. The most effective preventive compound was a doubly modified "hybrid" compound that contained fluorine.

The new deltanoids are, for the most part, identical to vitamin D, which is normally generated in the skin during exposure to sunlight. In several areas, though, Posner and his students have given the compounds' molecular structures several small "tweaks."

"We call our work molecular architecture, because at the submicroscopic level we are a
'"/>

Contact: Michael Purdy
mcp@jhu.edu
410-516-7906
Johns Hopkins University
21-Aug-2000


Page: 1 2 3

Related medicine news :

1. Molecular test predicts risk of breast cancer recurrence and who will benefit from chemotherapy
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Molecular tailoring of chemotherapy with novel imaging techniques
4. Molecular clock genes influence metabolism of sugar and dietary fats
5. Data announced at ISHLT: Molecular testing proves effective in monitoring heart transplant rejection
6. Molecular analyses of leukemia patients suggest strategies for better treatments
7. Molecular test proves to be effective in measuring remission and relapse after cancer treatment
8. Molecular tag pinpoints which breast cancer tumors are most likely to spread
9. Molecular mechanism underlaying anthrax infection described by UCSD School Of Medicine researchers
10. Molecularly targeted drug slows tumor growth in patients
11. Molecular self-assembly techniques used to coat biomedical substrates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/15/2019)... ... October 15, 2019 , ... ... Recent IFU Guidance , **An FDAnews Webinar**, Tuesday, October 29, 2019, 1:30-3:00 p.m. ... (IFU) guidance have on new drug applications and biologics license applications? , How ...
(Date:10/11/2019)... ... October 11, 2019 , ... Only 6% of orthopedic ... of them, as well as a female physician leading the sports medicine program. These ... girls who want to succeed in traditionally male-oriented fields. , Orthopedic medicine ...
(Date:10/10/2019)... ... October 10, 2019 , ... ... information technology (IT) services for the healthcare industry, has completed the first phase ... (PHA) of the Commonwealth of The Bahamas towards a fully integrated health information ...
(Date:10/8/2019)... ... October 08, 2019 , ... What unique insights can three former ... aging and wellness in the nation? That question will be answered at ICAA 2019: ... Summit and Expo. The event will take place October 10-12, 2019, at the Gaylord ...
(Date:10/8/2019)... WASHINGTON (PRWEB) , ... October 08, 2019 , ... ... development and support services for the Department of Veterans Affairs Community Care Referrals ... continue its implementation of the VA’s Health Share Referral Manager (HSRM), an enterprise-wide ...
Breaking Medicine News(10 mins):
(Date:10/11/2019)... ... ... MindShare Technology Founder and CEO Greg Povolny will offer his insights on using big ... Conference. The conference is at the Westin Indianapolis hotel in Indianapolis, IN with Povolny’s ... presentation will provide real world examples of how to apply complex analytics with a ...
(Date:10/10/2019)... ... October 10, 2019 , ... Global Composer ... ITTF Parkinson World Table Tennis Championships, October 11th – 13th,  , The debilitating effects ... public. So, he sought to find a way to combat the disease. A ...
(Date:10/10/2019)... NATOMAS, Calif. (PRWEB) , ... October 10, 2019 , ... ... of Dr. Glenn Misono in Natomas, California and opening of a new A+ location ... with seven convenient locations across the Sacramento area. The group’s 14 general dentists and ...
Breaking Medicine Technology:
Cached News: