HOME >> MEDICINE >> NEWS
Molecular clock genes influence metabolism of sugar and dietary fats

(Philadelphia, PA) Researchers at the University of Pennsylvania School of Medicine have discovered that components of the internal molecular clock of mammals have an important role in governing the metabolism of sugars and fats within the body. They found in mice that two of the well-studied proteins in the clock control the ability of animals to recover from the fall in blood sugar that occurs in response to insulin.

The investigators demonstrate a role for the circadian clock proteins, Bmal1 and Clock, in regulating the day-to-day levels of glucose in the blood. Suppressing the action of these molecules eliminates the diurnal variation in glucose and triglyceride levels. In addition, they found that a mutated Clock gene protected mice from diabetes induced by a high-fat diet. Together these findings represent the first molecular insight into how timing of what we eat via the clock can influence metabolism. The findings appear in the November 2 issue of the online journal PLoS Biology.

The master molecular clock in mammals is located in the brain in an area called the suprachiasmatic nucleus, clusters of neurons in the hypothalamus. Many of our basic functions, including regulating body temperature and hormone levels, vary throughout the day and night. Some of these changes may relate to being asleep or awake and on the job, but others are under the control of a biochemical timepiece that sets and resets daily.

Over the last several years, researchers have begun to appreciate that the molecular components of the clock exist in most, if not all, tissues of the body. Some years ago, a team led by senior author Garret FitzGerald, MD, Chairman of Penn's Department of Pharmacology, discovered a molecular clock in the heart and blood vessels and described for the first time how the master clock in the brain could use a hormone to control such a peripheral clock.

During the course of the group's rese
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
1-Nov-2004


Page: 1 2 3

Related medicine news :

1. Molecular test predicts risk of breast cancer recurrence and who will benefit from chemotherapy
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Molecular tailoring of chemotherapy with novel imaging techniques
4. Data announced at ISHLT: Molecular testing proves effective in monitoring heart transplant rejection
5. Molecular analyses of leukemia patients suggest strategies for better treatments
6. Molecular test proves to be effective in measuring remission and relapse after cancer treatment
7. Molecular tag pinpoints which breast cancer tumors are most likely to spread
8. Molecular mechanism underlaying anthrax infection described by UCSD School Of Medicine researchers
9. Molecularly targeted drug slows tumor growth in patients
10. Molecular self-assembly techniques used to coat biomedical substrates
11. Molecular nanogenerator developed that can target cancer cells and destroy them

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Molecular clock genes influence metabolism sugar and dietary fats

(Date:3/3/2015)... Burlington, VT (PRWEB) March 03, 2015 In ... world’s largest environmental networks, will kick off a new campaign, ... join the network’s businesses, nonprofits, and ambassadors in their quest ... Planet will work with several of its members and partners, ... Johnson’s All At Once network, to raise awareness for food ...
(Date:3/3/2015)... While it is clear that the prospect of ... drivers are signing up to UBI policies, more mature ... enticed. Due to current regulations, the application of UBI ... Its full capability is starting to be realised in ... breakdown services are at the top of the value-added ...
(Date:3/3/2015)... 2015 Today is International Ear Care ... the occasion to applaud and promote the launch of ... Health Organization (WHO) for stemming the threat of noise-induced ... young people to practice safe listening when they recreate, ... or sporting events, or engaging in other forms of ...
(Date:3/3/2015)... March 03, 2015 The Calistoga Chamber of ... of All Weekends,” taking place Friday, March 27, through Sunday, ... Pretty Muddy 5K fun run, restaurant and bar crawl, lodging ... open to women, ages 14 and older. , A variety ... getting in on the action by offering Mudder of All ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 In a ... Morning Edition, science correspondent Shankar Vedantam shared ... Pennsylvania about the drastic decrease in hand-hygiene compliance that occurs ... that the problem could be solved in part by alerts ... hygiene when they enter and exit a patient’s room. ...
Breaking Medicine News(10 mins):Health News:1% For the Planet Asks Consumers to “Know Your Source” 2Health News:TU-Automotive: Wawanesa Insurance to Discuss How UBI Can Produce Happy, Loyal Customers 2Health News:ASHA Applauds Launch of New WHO Campaign 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 2Health News:Visit Calistoga Hosts Mudder of All Weekends Girlfriend Getaway Event 3Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 2Health News:BIOVIGIL Hygiene Technologies Answers Call for Hand Hygiene Alerts on Badges 3
(Date:3/3/2015)... NEW YORK , March 3, 2015  This industry report package ... and future outlook for safety glass in the world and in the ... the package includes country reports from the following countries: ... , Germany , Italy , ... Turkey , United Kingdom , United ...
(Date:3/3/2015)...  UnaliWear announces the market preview of its first ... guards against wandering and provides support for falls and ... the Kanega watch ( http://www.UnaliWear.com ) – is also ... speech interface rather than buttons, use cellular and Wi-Fi ... The watch goes wherever the wearer goes ...
(Date:3/3/2015)... , March 3, 2015  Columbia Laboratories, Inc. ... " or "the Company"), a specialty pharmaceutical company focused ... will present at the 27th Annual ROTH Conference, which ... Laguna Niguel in Dana Point, California ... 11 at 9:00 a.m. Pacific Time (12:00 p.m. Eastern ...
Breaking Medicine Technology:Global Safety Glass Market to 2019 - Market Size, Top 10 Countries, Trends, and Forecasts 2UnaliWear's Wearable For Seniors Extends Independence With Advanced Technology 2
Cached News: