HOME >> MEDICINE >> NEWS
Molecular mechanism underlaying anthrax infection described by UCSD School Of Medicine researchers

The mechanism by which inhaled anthrax disarms and evades the immune system, enabling the potentially lethal bacteria to rapidly spread throughout the body, has been described by researchers at the University of California, San Diego (UCSD) School of Medicine.

Published online Aug. 29 in Science Express, the website of the journal Science, the lab-culture research with mouse cells describe how a complex of Bacillus anthracis (anthrax) proteins called lethal toxin (LT) inhibits and destroys macrophages, the large white blood cells that act as the body's first defense against pathogens, and also disables the signaling mechanism triggering immune activation. This allows the bacteria to spread through the body unchecked by the immune system, resulting in rapid and potentially lethal anthrax infection.

When the bacterium (b. anthracis) is inhaled, its spores are surrounded by alveolar macrophages in the lung, the beginning stage of normal immune response. But instead of succumbing to the defensive assault, they survive and germinate within the cells, traveling with the macrophages in their normal sentinel duty throughout the body to the lymph nodes, and eventually into the bloodstream, ultimately leading to fatal systemic shock if treatment fails.

In order to understand how anthrax was evading the immune system, the research team led by Michael Karin, Ph.D., UCSD professor of pharmacology and American Cancer Society Research Professor, used a variety of lab tests to determine how LT caused cell death in mouse macrophage cells. They pinpointed a series of steps, and specifically inhibition of an enzyme (a protein kinase) called p38, that lead to macrophage death and prevent secretion of chemokines and cytokines, the signaling agents that alert the immune system to the presence of an invading pathogen.

According to Karin, these findings open the door for development of an antidote that could block the action of a specific toxin called leth
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
29-Aug-2002


Page: 1 2

Related medicine news :

1. Molecular test predicts risk of breast cancer recurrence and who will benefit from chemotherapy
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Molecular tailoring of chemotherapy with novel imaging techniques
4. Molecular clock genes influence metabolism of sugar and dietary fats
5. Data announced at ISHLT: Molecular testing proves effective in monitoring heart transplant rejection
6. Molecular analyses of leukemia patients suggest strategies for better treatments
7. Molecular test proves to be effective in measuring remission and relapse after cancer treatment
8. Molecular tag pinpoints which breast cancer tumors are most likely to spread
9. Molecularly targeted drug slows tumor growth in patients
10. Molecular self-assembly techniques used to coat biomedical substrates
11. Molecular nanogenerator developed that can target cancer cells and destroy them

Post Your Comments:
(Date:5/26/2015)... Beginning this fall, Boston University will ... Master of Social Work (MSW) program . Already available ... River Campus, the online option will be offered starting ... option is open to applicants holding an undergraduate social ... Education. Students entering the program will be granted 22 ...
(Date:5/26/2015)... Dearborn Ear, Nose & Throat in Dearborn, MI ... and improved website to better showcase their Detroit area ... Nose & Throat’s new website utilizes an innovative and ... seamlessly on any desktop computer, tablet or mobile device. ... Nose & Throat website include an innovative design ...
(Date:5/25/2015)... 2015 The report “Liver Failure ... on the therapeutic development for Liver Failure. The ... and MOAs to produce first-in-class and best-in-class products. ... Liver Failure with 22 market data tables and ... at http://www.rnrmarketresearch.com/liver-failure-pipeline-review-h1-2015-market-report.html . , Companies discussed ...
(Date:5/25/2015)... (PRWEB) May 26, 2015 Author Vincent N. ... of people today are overweight, and many of them aren’t ... He also knows that most people don’t realize the dangers ... hazards and man-made toxins that exist. There is ... realize exactly how serious tobacco is.” , In “ A ...
(Date:5/25/2015)... City, NY (PRWEB) May 26, 2015 ... honors Laquanis Hooker as a 2015-2016 inductee into its ... recognized with this prestigious distinction for leadership in dentistry. ... professional women, boasting more than 700,000 members and over ... welcome Laquanis into this exceptional group of professional women,” ...
Breaking Medicine News(10 mins):Health News:Boston University to Offer Online Master of Social Work Advanced Standing Option 2Health News:Boston University to Offer Online Master of Social Work Advanced Standing Option 3Health News:Dearborn Ear, Nose & Throat Launches ‘Responsive Design’ Website 2Health News:Liver Failure Pipeline Assessment and Key Players Review H1 2015 Market Research Report Available at RnRMarketResearch.com 2Health News:Liver Failure Pipeline Assessment and Key Players Review H1 2015 Market Research Report Available at RnRMarketResearch.com 3Health News:Liver Failure Pipeline Assessment and Key Players Review H1 2015 Market Research Report Available at RnRMarketResearch.com 4Health News:New Book Reveals ‘A Doctor’s Prescription for Longevity and Survival’ 2Health News:New Book Reveals ‘A Doctor’s Prescription for Longevity and Survival’ 3Health News:National Association of Professional Women Inducts Dr. Laquinas Hooked, D.D.S. of General Dentist, Into its VIP Professional Woman of the Year Circle 2
(Date:5/22/2015)... -- RegeneRx Biopharmaceuticals, Inc. (OTCQB: RGRX), a clinical-stage drug development ... announced that J.J. Finkelstein , chief executive officer ... at two upcoming investor conferences. Mr. ... Annual Microcap Conference on Thursday May 28, 2015 in ... am EDT.  A webcast will be available at the ...
(Date:5/22/2015)... -- The Mesothelioma Victims Center is incredibly passionate about ... best possible compensation, and they are also extremely focused ... caused by exposure to asbestos or their family ... options such as a recent possible medical breakthrough. For ... anytime at 866-714-6466. http://MesotheliomaVictimsCenter.Com ...
(Date:5/22/2015)... May 22, 2015 Research and Markets ... of the "Latest Regulations on Pharmaceutical International ... their offering. This is first time ... guidance on international multi-center clinical trials of drugs ... begun to be implemented on March 1, 2015. ...
Breaking Medicine Technology:RegeneRx to Present at 2 Investor Conferences 2RegeneRx to Present at 2 Investor Conferences 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 2Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 3Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 4Mesothelioma Victims Center Calls Attention to a Recent Medical Article About a New Drug That Could Slow the Progression of Mesothelioma and Allow People to Live Longer 52015 Regulations on Pharmaceutical International Multi-Center Clinical Trials in China 2
Cached News: