HOME >> MEDICINE >> NEWS
Molecular mechanism underlaying anthrax infection described by UCSD School Of Medicine researchers

The mechanism by which inhaled anthrax disarms and evades the immune system, enabling the potentially lethal bacteria to rapidly spread throughout the body, has been described by researchers at the University of California, San Diego (UCSD) School of Medicine.

Published online Aug. 29 in Science Express, the website of the journal Science, the lab-culture research with mouse cells describe how a complex of Bacillus anthracis (anthrax) proteins called lethal toxin (LT) inhibits and destroys macrophages, the large white blood cells that act as the body's first defense against pathogens, and also disables the signaling mechanism triggering immune activation. This allows the bacteria to spread through the body unchecked by the immune system, resulting in rapid and potentially lethal anthrax infection.

When the bacterium (b. anthracis) is inhaled, its spores are surrounded by alveolar macrophages in the lung, the beginning stage of normal immune response. But instead of succumbing to the defensive assault, they survive and germinate within the cells, traveling with the macrophages in their normal sentinel duty throughout the body to the lymph nodes, and eventually into the bloodstream, ultimately leading to fatal systemic shock if treatment fails.

In order to understand how anthrax was evading the immune system, the research team led by Michael Karin, Ph.D., UCSD professor of pharmacology and American Cancer Society Research Professor, used a variety of lab tests to determine how LT caused cell death in mouse macrophage cells. They pinpointed a series of steps, and specifically inhibition of an enzyme (a protein kinase) called p38, that lead to macrophage death and prevent secretion of chemokines and cytokines, the signaling agents that alert the immune system to the presence of an invading pathogen.

According to Karin, these findings open the door for development of an antidote that could block the action of a specific toxin called leth
'"/>

Contact: Sue Pondrom
spondrom@ucsd.edu
619-543-6163
University of California - San Diego
29-Aug-2002


Page: 1 2

Related medicine news :

1. Molecular test predicts risk of breast cancer recurrence and who will benefit from chemotherapy
2. Jefferson and Molecular Targeting Technologies, Inc. scientists create vaccine for wildlife rabies
3. Molecular tailoring of chemotherapy with novel imaging techniques
4. Molecular clock genes influence metabolism of sugar and dietary fats
5. Data announced at ISHLT: Molecular testing proves effective in monitoring heart transplant rejection
6. Molecular analyses of leukemia patients suggest strategies for better treatments
7. Molecular test proves to be effective in measuring remission and relapse after cancer treatment
8. Molecular tag pinpoints which breast cancer tumors are most likely to spread
9. Molecularly targeted drug slows tumor growth in patients
10. Molecular self-assembly techniques used to coat biomedical substrates
11. Molecular nanogenerator developed that can target cancer cells and destroy them

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/4/2016)... ... 2016 , ... Washington Wellness Center today announced its tenth anniversary of providing ... started out as an idea to provide a holistic approach to wellness has now ... by Dr. David Swanekamp, Chiropractic Physician , the wellness center offers a complete ...
(Date:5/4/2016)... ... 2016 , ... Dr. Elyson and Dr. Assili, dentist in Northridge , ... tooth removal, a common dental procedure, is performed for many adolescents and young adults ... in risks of complications. By providing wisdom tooth removal surgery at their office, Dr. ...
(Date:5/4/2016)... ... May 04, 2016 , ... Recognizing that lifestyle medicine is essential to health ... have tapped David Katz, MD, MPH, president of the American College of Lifestyle Medicine, ... medicine is especially gratifying,” said Katz. “There is so much opportunity to add years ...
(Date:5/4/2016)... , ... May 04, 2016 , ... ... the pharmacy industry, today announced that it was chosen as the Pharmaceutical News ... Industry Awards . The awards acknowledge the hard work and dedication of community ...
(Date:5/4/2016)... ... May 04, 2016 , ... Advanced Spine & Sport Medical ... its patients’ health, is hosting a free seminar on stem cell injections. The seminar ... Advanced Spine & Sport, 4601 Telephone Road, Suite 110, Ventura, CA. There are only ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... COUNTY, Calif. , May 3, 2016  While you may be familiar with watching a ... resolution , also known as ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is a ... manufacturer of innovative technology. Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
(Date:5/3/2016)... Calif. , May 3, 2016  Specialty ... teaching tool that shows how a cleanroom works. ... classroom discussions about science and technology. ... said, "As a technology company, SSF enthusiastically supports ... to help educators foster the next generation of ...
(Date:5/2/2016)... , May 2, 2016 Kalorama Information ... (Electronic Medical Records) market in a recent white paper.  ... switches, Increased physician usage, a growing market are among ... noted in Kalorama,s report EMR 2016: The ... marks Kalorama,s seventh complete study of the EMR industry, ...
Breaking Medicine Technology:
Cached News: