Khandan Keyomarsi, Ph.D., associate professor in experimental radiation at M. D. Anderson, and her colleagues report in the November 14, 2002, issue of the New England Journal of Medicine that high levels of a protein called cyclin E are closely associated with aggressive, invasive breast cancer. The study, conducted with tissue samples of current or former breast cancer patients, appears to show that cyclin E is a much better predictor of patient outcome than any current predictive marker. However, says Keyomarsi, the study must be repeated with newly diagnosed patients to determine its true predictive value.
The ability to predict which breast cancer tumors will recur or spread throughout the body is an important aspect of breast cancer treatment, says Keyomarsi. Currently, the prognosis for women diagnosed with breast cancer is determined by whether tumor cells have spread to lymph nodes. But some women who have cancer cells in the lymph nodes never have a recurrence, while others whose cancer has not spread do have a recurrence. Yet many women, after discussions with their doctors, opt to undergo grueling chemotherapy in hopes of ensuring any rogue cancer cells that may be present are killed. If an accurate predictive marker were available, many women could be spared chemotherapy, she says.
In the study, Keyomarsi and her colleagues looked for the presence of cyclin E because when this protein is present at high levels inside cancer cells it signals cells to multiply all the time. In normal cells, cyclin E is present only for a short time and helps keep cell division under tight control. In addition, the scientists discovered smaller versions of cyclin E that are not pres
Contact: Laura Sussman
University of Texas M. D. Anderson Cancer Center