HOME >> MEDICINE >> NEWS
Molecule predicts colon cancer patient survival

Harvard researchers have examined the factors that help spur the progression of colorectal cancer and identified the integrin v6 as an important risk factor for development of early-stage disease. They further demonstrate that detection of high levels of this molecule is able to predict patient survival for colorectal cancer, a disease that kills over 55, 000 Americans each year. The study will appear online on January 20 in advance of publication in the February 1 print edition of the Journal of Clinical Investigation.

During embryonic development or wound repair, epithelial cells that line cavities within the body often undergo a change of shape and function in a process known as epithelial-mesenchymal transition (EMT). On occasion, this transition can result in the conversion of epithelial cells to tumor cells.

Richard Bates and colleagues, interested in determining what factors disrupt normal EMT and drive the development of tumor cells, examined the EMT process in colon carcinoma cells. They found that EMT involves activation of the protein integrin known as v6 and this protein enhances the tumor-generating properties of these cells. Furthermore, analysis of almost 500 human colorectal carcinoma samples revealed that elevated levels of v6 expression were associated with a significantly reduced survival time of patients in comparison with tumors that express little or low levels of this molecule.

The results define v6 expression as an independent prognostic marker for colorectal cancer and, most significantly, one that is predictive of the outcome of early-stage disease.


'"/>

Contact: Brooke Grindlinger
press_releases@the-jci.org
212-342-9006
Journal of Clinical Investigation
20-Jan-2005


Page: 1

Related medicine news :

1. Molecule important in cell construction also critical in learning and memory
2. Molecule pumped directly into brain improves Parkinsons disease symptoms
3. Molecule expressed early in pregnancy may help patients tolerate transplants
4. Molecules inhibit HIV protease, could lead to new line of attack against AIDS
5. UK Researchers Receive $1.14 Million NIH Grant To Study A Molecule That May Have A Role In Diseases Involving Oxidative Cell Death
6. Immunexs TRAIL Molecule Shows Potential As Anti-Tumor Agent
7. New evaluation tool reliably predicts recovery from coma
8. New scale predicts recovery of consciousness from coma after brain injury
9. Computational tool predicts how drugs work in cells, advancing efforts to design better medicines
10. Depression predicts heart rhythm abnormalities in heart attack patients
11. A shallow hip socket predicts osteoarthritis of the hip

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... ... Arkansas that offers insurance and financial preparation services, is providing an update on ... Rescue organization. , Rock City Rescue is a locally recognized nonprofit that provides ...
(Date:10/13/2017)... Nevada (PRWEB) , ... October 13, 2017 , ... ... Hemp CBD Oil utilizing Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil ... required and providing a CBD form that can be easily incorporated into liquid products, ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) ... a collection of specialty vendors and unique items from across the nation, this holiday-themed ... and wellness services offered by the VNA. The boutique will be open Saturday, ...
(Date:10/13/2017)... ... 13, 2017 , ... Coveros, a leader in agile coaching ... contract by the Center for Medicare and Medicaid Services (CMS). The Enterprise Agile ... of Agile methodologies in a consistent and high value manner across CMS programs. ...
(Date:10/12/2017)... ... 2017 , ... Planet Fitness, one of the largest and fastest growing franchisors ... a flagship location in Covington, LA at 401 N. U.S. Highway 190, in January ... Office Depot in the Holiday Square shopping center. Its location allows it to serve ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  Commended for their devotion to ... awards. Ranked as number one in the South Florida Business ... in Inc. 5000 yearly list, the national specialty pharmacy has ... Armando Bardisa will soon be honored by SFBJ as ... Set to receive his award in October, ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
(Date:9/18/2017)... Sept. 18, 2017 EpiVax, Inc. ... bioinformatics and immune engineering, today announced a ... A (H7N9) vaccine. ... seasonal influenza and presents a challenge for ... exposure to be effective. Using state-of-the-art bioinformatics and ...
Breaking Medicine Technology:
Cached News: