HOME >> MEDICINE >> NEWS
Mood elevating hormone may trigger depression and heart problems

New Haven, Conn.--Impaired function of a receptor that regulates release of a mood elevating hormone in the brain may be responsible for causing depression, anxiety and cardiovascular disorders, according to a Yale study in Pharmacogenetics and Genomics.

The genetic variant that causes this malfunction is nearly 15 times as prevalent in African-Americans as Caucasians and might explain why African-Americans have a higher rate of congestive heart failure, according to the first author, Alexander Neumeister, M.D., associate professor in the Department of Psychiatry at Yale School of Medicine.

In his study of 29 healthy African-Americans, 11 had the genetic variant, nine were carriers of the genetic variant, and nine were not carriers. Those who tested positive for the genetic variant had elevated norepinephrine levels, heart rate and blood pressure, suggesting impaired receptor function. The effects were more pronounced after the subjects were given a medication that blocked the action of the receptor, causing a sustained release of norepinephrine.

"The subjects had a higher blood pressure response and a higher heart rate," Neumeister said. "They were perfectly normal people, but at baseline and when injected with a medication to block the receptor their test results indicated they might be at higher risk for hypertension. They also were more anxious than people without this genetic variant."

The key regulator of norepinephrine function is the alpha-2 receptor. When norepinephrine is released, it binds to this receptor, sending out a signal to block the release of norepinephrine.


'"/>

Contact: Jacqueline Weaver
jacqueline.weaver@yale.edu
203-432-8555
Yale University
4-Mar-2005


Page: 1

Related medicine news :

1. Growth hormone treatment improves symptoms of metabolic disorder in postmenopausal women
2. The history and controversy behind post-menopausal hormone therapy
3. Female sex hormones play a vital role in defense against sexually transmitted diseases
4. Sex hormone metabolite reduces stress, anxiety in female rats
5. New study finds kelp can reduce level of hormone related to breast cancer risk
6. Combining hormones with external, internal radiation helps high risk prostate cancer patients
7. Sleep duration affects appetite-regulating hormones
8. Abdominal fat decreases, insulin action improves when elderly take hormone
9. New insights into hormone therapy highlight when estrogen best aids brain
10. Gender and sex hormones affect the brains pain response and more, according to new studies
11. Teenage hormone therapy to reduce adult height of tall girls linked to reduced fertility

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/17/2019)... ... August 17, 2019 , ... ... America’s Fastest-Growing Private Companies—the Inc. 5000 , For the 2nd Year In a ... Revenue Growth of 192% Percent , Inc. magazine today revealed that YellowTelescope LLC ...
(Date:8/16/2019)... ... August 16, 2019 , ... The employees ... children’s aircraft to Ronald McDonald House Charities in New Hyde Park, Long Island, ... medical treatments and their family members a comfortable and fun way to watch ...
(Date:8/15/2019)... ... August 15, 2019 , ... ... pathology residents who have been directly affected by the closure of Hahnemann University ... donations gathered during the campaign, the ASCP Foundation will be making hardship grants ...
(Date:8/14/2019)... (PRWEB) , ... August 14, 2019 , ... Teguar Corporation ... companies in America. This list has long-been established as a mark of success for ... LinkedIn, Dell, and Oracle. Teguar made the list in 2015, 2016 and 2017. This ...
(Date:8/14/2019)... N.H. (PRWEB) , ... August 13, 2019 , ... New ... the heart-healthy antioxidant resveratrol, today announced an expansion of its line of CBD-infused coffees ... 300 mg of CBD in a 12-oz bag. , “We are excited to ...
Breaking Medicine News(10 mins):
(Date:8/9/2019)... ISLAND, N.Y. (PRWEB) , ... August 09, 2019 ... ... today announced their Lynbrook location, currently at 360 Merrick Road, will be moving ... 3rd, 2019. , The new Oceanside office offers additional features and technologies to ...
(Date:8/9/2019)... , ... August 09, 2019 , ... ... annual conference in its 15-year history, themed “The Foundation of Health Care,” at ... CM-granting conference will feature a variety of prestigious keynote presenters, including Lifestyle Medicine ...
(Date:8/9/2019)... ... August 08, 2019 , ... Isagenix International , ... its second round of Canada finalists for its annual total-body transformation program, the ... Selwyn, Ontario; Dwight Hodel of Medicine Hat, Alberta; Jennifer Bounds of Fort McMurray, ...
Breaking Medicine Technology:
Cached News: