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Most Comprehensive Study Of Its Kind Shows Common Asthma Medications Don't Cause Behavioral Problems In Children, According To The Journal Pediatrics

DENVER- The asthma medications beclomethasone and theophylline have reported side effects, such memory, mood and behavior changes, but an article in the March issue of the journal Pediatrics shows that in most children, the drugs cause no major changes in behavior or reasoning skills. Both drugs have been prescribed to treat asthma for decades.

"For the most part, mainstream drugs used to treat asthma are safe-in this case safe from psychological consequences," said Bruce Bender, Ph.D., head of Neuropsychology at National Jewish Medical and Research Center and principal investigator of the study. "Patients with chronic illness in general tend not to take their medications. When a parent has doubts about a medication, that tendency is amplified, often to the child's detriment in the long run. We hope that this study will help alleviate some of the fears parents may have about giving a child beclomethasone or theophylline."

Parents of more than 100, 6- to 17-year-old children with asthma completed behavioral questionnaires at the beginning of the study, at one month and one year. The children, who all had been diagnosed with asthma on average for 7 years, were tested for attention, concentration, memory, problem solving and learning skills. No significant side effects or differences between beclomethasone and theophylline were found in the study.

Although theophylline has a reputation among doctors and parents for causing behavioral problems in children, this research shows this isn't true in the age group examined. "No one has really looked at the potential psychological side effects of inhaled steroids before," Bender said. "There have been a couple of case reports that stated children developed serious behavior problems on inhaled steroids, but these reports often aren't accurate."

The study found that neither beclomethasone nor theophylline s
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Contact: Jordan Gruener
gruener.jordan@njrc.org
303-398-1002
National Jewish Medical and Research Center
2-Mar-1998


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