HOME >> MEDICINE >> NEWS
Mouse gene shows new mechanism behind cardiac infarction in man

Mouse gene shows new mechanism behind cardiac infarction in man

A gene that, in different variants, increases or decreases the level of atherosclerosis has been identified in mice. The corresponding human gene has been shown to play a role in the development of myocardial infarction. The results of the study is published this week on Nature Genetics Online.

Researchers at Karolinska Institutet, in collaboration with the Jackson Laboratory in the USA, AstraZeneca and a Japanese research group, have scrutinised an area on chromosome 1 that is of demonstrable importance to the development of arteriosclerosis. The TNFSF4 gene was identified as the one responsible, as mice with mutations in this gene displayed a lower degree of atherosclerosis, while mice with more active variants of the gene displayed the opposite.

Studies of two patient groups revealed that a certain variant of the human homologue of the gene was more common in people who had a history of cardiac infarction than those without.

"This is an example of how an unbiased genetic strategy based on a mice model can teach us more about common human diseases," says researcher Jacob Lagercrantz of the Gustav V research institute, Karolinska Institutet.

The gene codes for a protein called OX40L, which is involved in the activation of immunological T cells. These cells, in turn, play an important role in the pathogenesis of atherosclerosis and of a number of chronic inflammatory diseases. The new finding will spur further research into the relationship between the protein and cardiac infarction. Hopefully it will offer a new therapeutic technique for the treatment of atherosclerosis and thus reduce the risk of cardiac infarction.


'"/>

Contact: Jacob Lagercrantz
jacob.lagercrantz@cmm.ki.se
46-8-517 703 16
Karolinska Institutet
8-Mar-2005


Page: 1

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse model gives insight to human hair loss
3. Mouse study: Signal overload in Alzheimer brains
4. Mouse shows how Rituximab removes human B cells
5. Mouse study could aid vaccine designers
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/6/2019)... ... December 06, 2019 , ... ... for excellence in employee learning. The Omaha-based company has been named by Training ... most successful employer-sponsored training and development programs worldwide. Rankings of the 125 leading ...
(Date:12/6/2019)... HARTFORD, Conn. (PRWEB) , ... December 06, 2019 ... ... that is consistently recognized for its innovations and excellence in patient care. On ... upholding that standard of excellence at the Health Care Heroes Awards at the ...
(Date:12/6/2019)... ... December 06, 2019 , ... Allegheny Health Network (AHN) has named ... joined AHN from WVU Medicine in May 2018, previously served as AHN’s Vice Chair ... interim chair since October and is also part of the pathology faculty at Drexel ...
(Date:12/6/2019)... HUNTINGTON, N.Y. (PRWEB) , ... December 06, ... ... they are now the preferred HIPAA compliance solution for the Wyoming Medical Society. ... HIPAA compliance. , Healthcare entities have an obligation to adhere to the ...
(Date:12/6/2019)... ... December 06, 2019 , ... TIME For Kids (TFK) revealed the ... educational, innovative, and fun destinations that are tailored to the interests of kids. The ... , To assemble the list, TIME for Kids gathered nominations from its network of ...
Breaking Medicine News(10 mins):
(Date:12/14/2019)... ... December 13, 2019 , ... Nootropic ... non-GMO, vegan, gluten-free drinkable nootropic supplement curated with research-backed ingredients for cognitive support, ... long-lasting, is a potent nootropic containing the equivalent of eleven capsules packed into ...
(Date:12/9/2019)... ... 09, 2019 , ... Hawaii Health Systems Corporation (HHSC) Oahu ... State Senate President Ronald Kouchi. As part of the broad effort, the initiative ... In addition to local food sourcing, the initiative will expand service to meet ...
(Date:12/9/2019)... ... December 09, 2019 , ... ... been honored for their work in improving workforce performance with a Brandon ... Technology category. The Excellence Awards recognize the best organizations that have successfully ...
Breaking Medicine Technology:
Cached News: