HOME >> MEDICINE >> NEWS
Mouse model gives insight to human hair loss

A progressive skin disease causing hair loss in adult humans was identified in laboratory mice, providing a genetic tool to study the disease known as alopecia areata (AA).

"Our mouse model has proven to be very useful as a preclinical model to test new treatments for alopecia areata before being used in humans," states lead researcher, John P. Sundberg, D.V.M., Ph.D., of The Jackson Laboratory inBar Harbor, Maine. The study further provided the opportunity to use newly available gene array technology to study AA's molecular mechanisms.

In this 5-year study, published in the Journal of Investigative Dermatology, researchers identified a virtually identical mouse model for human adult onset AA and were able to reproduce the disease for exploring treatments. Data revealed that the disease has a complicated genetic basis that involves 4 or more genes. These genes include those involved in susceptibility to the disease and genes that regulate pigmentation of the skin and hair.

"This [study] provides data for analyzing the genetic candidates responsible for AA as well as insights into other conditions, such as thyroid disorders, which have been associated with AA subsets," as summarized in the November "Clinical Snippets" published in the journal. "Random genome-wide linkage screenings in mice and humans can lead to greater understanding of AA and other complex polygenic diseases."

Alopecia areata is a highly unpredictable, autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body, according to the National Alopecia Areata Foundation. The condition is common, affecting both males and females in approximately 1.7 percent of the world population overall. This accounts for more than 4.7 million people in the United States alone.


'"/>

Contact: Sharon Agsalda
medicalnews@bos.blackwellpublishing.net
781-388-8507
Blackwell Publishing Ltd.
10-Nov-2004


Page: 1

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse study: Signal overload in Alzheimer brains
4. Mouse shows how Rituximab removes human B cells
5. Mouse study could aid vaccine designers
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( ... today the introduction of an innovative new design of the shoulder pad. The ... get maximum comfort while controlling your pain while using cold therapy. By utilizing ice ...
(Date:10/12/2017)... ... October 12, 2017 , ... Information ... we intend to develop to enable prevention of a major side effect of ... loss, especially in pediatric patients. For cisplatin, hearing loss is FDA listed on-label ...
(Date:10/12/2017)... ... 2017 , ... Leading pediatric oncology experts at Children’s National Health System ... Congress of the International Society of Paediatric Oncology (SIOP) Oct. 12-15. Chaired by ... and Blood Disorders at Children’s National, and Stephen P. Hunger, M.D., Chief of ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... nation's first interactive health literacy software tool, and the Cancer Patient Education Network ... cancer patient education, today announce a new strategic alliance. , As CPEN’s ...
(Date:10/12/2017)... D.C. (PRWEB) , ... October 12, 2017 , ... ... Cal Dining at the University of California Berkeley, and other leading institutions in ... the buying power of institutions to change the way animals are raised for ...
Breaking Medicine News(10 mins):
(Date:9/27/2017)... , Sept. 27, 2017  DarioHealth Corp. (NASDAQ: DRIO), a leading global ... that its MyDario product is expected to appear on The Dr. Oz ... Dr. Oz Show airs in your area: http://www.doctoroz.com/page/where-watch-dr-oz-show ... The nine-time Emmy award-winning, The Dr. Oz Show kicked ... The segment features ...
(Date:9/25/2017)... , Sept. 25, 2017  EpiVax, Inc., ... vaccine design, and immune-engineering today announced the launch ... the development of personalized therapeutic cancer vaccines. EpiVax ... provided exclusive access to enabling technologies to the ... MBA will lead EpiVax Oncology as Chief Executive ...
(Date:9/22/2017)... Md. , Sept. 22, 2017  As the ... Republican Senators Bill Cassidy (R-LA) and ... Information notes that the medical device industry is in ... medical device tax, the 2.3% excise tax on medical ... But they also want covered patients, increased visits and ...
Breaking Medicine Technology:
Cached News: