HOME >> MEDICINE >> NEWS
Mouse model gives insight to human hair loss

A progressive skin disease causing hair loss in adult humans was identified in laboratory mice, providing a genetic tool to study the disease known as alopecia areata (AA).

"Our mouse model has proven to be very useful as a preclinical model to test new treatments for alopecia areata before being used in humans," states lead researcher, John P. Sundberg, D.V.M., Ph.D., of The Jackson Laboratory inBar Harbor, Maine. The study further provided the opportunity to use newly available gene array technology to study AA's molecular mechanisms.

In this 5-year study, published in the Journal of Investigative Dermatology, researchers identified a virtually identical mouse model for human adult onset AA and were able to reproduce the disease for exploring treatments. Data revealed that the disease has a complicated genetic basis that involves 4 or more genes. These genes include those involved in susceptibility to the disease and genes that regulate pigmentation of the skin and hair.

"This [study] provides data for analyzing the genetic candidates responsible for AA as well as insights into other conditions, such as thyroid disorders, which have been associated with AA subsets," as summarized in the November "Clinical Snippets" published in the journal. "Random genome-wide linkage screenings in mice and humans can lead to greater understanding of AA and other complex polygenic diseases."

Alopecia areata is a highly unpredictable, autoimmune skin disease resulting in the loss of hair on the scalp and elsewhere on the body, according to the National Alopecia Areata Foundation. The condition is common, affecting both males and females in approximately 1.7 percent of the world population overall. This accounts for more than 4.7 million people in the United States alone.


'"/>

Contact: Sharon Agsalda
medicalnews@bos.blackwellpublishing.net
781-388-8507
Blackwell Publishing Ltd.
10-Nov-2004


Page: 1

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse study: Signal overload in Alzheimer brains
4. Mouse shows how Rituximab removes human B cells
5. Mouse study could aid vaccine designers
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/5/2019)... ... December 05, 2019 , ... Today at M Health Fairview ... newest staff member who will to help them take medicine, relax during anxious ... procedures.  , Rocket, presented by NutriSource® is a golden retriever and the first ...
(Date:12/4/2019)... ... December 04, 2019 , ... Healthcare Real Estate ... only national awards dedicated to recognizing excellence in the areas of healthcare real ... in nine different categories during the GlobeSt Healthcare Conference today in Scottsdale, Ariz. ...
(Date:12/2/2019)... , ... December 02, 2019 , ... More than $400 ... midnight on December 31. While many people spend their tax-free funds throughout the year, ... on New Year’s Eve. In an effort to help account holders use -- not ...
(Date:11/30/2019)... ... November 28, 2019 , ... As American families gather to ... such holiday for one of their loved ones. For those with a life-limiting illness, ... for the holiday season. , Spending their final months at home takes on special ...
(Date:11/30/2019)... ... November 29, 2019 , ... This Black Friday through Cyber ... family of brands—Gorilla Grow Tent, Kind LED Grow Lights, Lotus Nutrients, and SuperCloset. ... 5’x5’ Gorilla Grow Tent . The best-selling grow tent in Gorilla’s collection, the ...
Breaking Medicine News(10 mins):
(Date:12/4/2019)... (PRWEB) , ... December 04, ... ... leader in delivering solutions designed for improved financial, operational and clinical health ... earned the Fellow designation from the American College of Healthcare Executives (ACHE). ...
(Date:12/2/2019)... ... 02, 2019 , ... Data integration has been a pharma industry buzzword for ... external data sources, staff are still working in silos and are not aware of ... six weeks or more, and nearly one-third of qualified investigators may be overlooked. Innovations ...
(Date:12/2/2019)... ... December 02, 2019 , ... Today asensei, Feed.fm, Mux and WEEL announce the ... digital fitness experience creators. , As more and more Connected Fitness products hit the ... products and decrease time to market. This partnership was forged to address that gap ...
Breaking Medicine Technology:
Cached News: