HOME >> MEDICINE >> NEWS
Mouse model mimics real-world plague infection

An experimental plague vaccine proved 100 percent effective when tested in a new mouse model for plague infection developed by scientists at Rocky Mountain Laboratories (RML), part of the National Institute of Allergy and Infectious Diseases (NIAID) of the National Institutes of Health. The scientists developed their model to mimic the natural transmission route of bubonic plague through the bites of infected fleas. The flea-to-mouse model provides a more realistic test setting than previously used methods, enabling a better assessment of a vaccine's ability to protect against a real-world challenge.

The new report, authored by lead researcher and RML plague expert B. Joseph Hinnebusch, Ph.D., appears in the April edition of Infection and Immunity, now available online. Collaborators included Clayton O. Jarrett, M.S., and Florent Sebbane, Ph.D., of RML in Hamilton, MT; and Jeffrey J. Adamovicz, Ph.D., and Gerard P. Andrews, Ph.D., of the U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), where the recombinant plague vaccine tested in the model was made.

"Replicating the natural transmission of plague from flea to host in this model is tedious and unusual work," notes NIAID Director Anthony S. Fauci, M.D. "This creative approach, however, brings researchers much closer to answers to real-life questions."

In their study, the RML scientists first infected fleas by letting them feed on blood containing a virulent strain of Yersinia pestis, the bacterial agent of plague. The infected fleas then fed on 15 mice that had been inoculated with the experimental vaccine containing an adjuvant (an immune booster). For comparison, the researchers let infected fleas also feed on a second group of 15 mice that had received only the adjuvant.

Although all 15 vaccinated mice remained symptom-free even after multiple feedings by the fleas, plague occurred in 14 of the 15 mice that had received the adjuvant alo
'"/>

Contact: Ken Pekoc
kpekoc@niaid.nih.gov
406-375-9690
NIH/National Institute of Allergy and Infectious Diseases
24-Mar-2004


Page: 1 2 3

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse study could aid vaccine designers
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Apple ... care services, staged a mock evacuation of the facility as part of a disaster ... Fire Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the ... danger possible to save lost souls in the Philippines. “The Journey: From the Mountains ... a dedicated teacher of the Bible. She has taught all ages and currently teaches ...
(Date:10/12/2017)... ... October 12, 2017 , ... Planet Fitness, one of the largest and ... plans to open a flagship location in Covington, LA at 401 N. U.S. Highway ... store next to Office Depot in the Holiday Square shopping center. Its location allows ...
(Date:10/12/2017)... ... 2017 , ... Asante, a nationally recognized health system in ... existing home health joint venture through an agreement, effective October 1, 2017, to ... home health company with Asante, delivering clinically integrated care, for the past eight ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... -- NDS received FDA 510(k) clearance in May 2017 for its highly ... designed for endoscopy environments. An innovative secondary monitor solution, ZeroWire ... support the improvement of patient outcomes, procedural efficiency, and the lowering ... ... ...
(Date:10/4/2017)... 4, 2017  South Korean-based healthcare product Development Company ... "cprCUBE" on Kickstarter. The device will educate the user ... with better efficiency compared to the dated and pricey ... on efficacy of the compression for a more informed ... goal to raise $5,000. ...
(Date:10/2/2017)... 2017  Eli Lilly and Company (NYSE: ... third quarter of 2017 on Tuesday, October 24, 2017. ... day with the investment community and media to further ... call will begin at 9 a.m. Eastern time. Investors, ... webcast of the conference call through a link that ...
Breaking Medicine Technology:
Cached News: