HOME >> MEDICINE >> NEWS
Mouse model reveals potential way to reduce cardiac deaths in kidney patients

St. Louis, March 29, 2005 -- Scientists have identified an important link between kidney damage and cardiac problems, creating new possibilities for treating the primary cause of death in kidney disease patients.

Researchers tracked a chain reaction that leads from kidney damage to weakening of the skeleton to increased phosphorous in the blood. They showed that higher phosphorous levels were directly linked to vascular calcification, a stiffening of the smooth muscle cells that line blood vessels. Vascular calcification leads to enlargement of one of the heart's four chambers, increased risk of congestive heart failure, heart attack and several other cardiac problems.

Mice treated with an experimental medication that alleviates the skeletal weakening brought on by kidney damage had normal phosphorous levels and decreased signs of vascular calcification.

"We already have treatments available that can control phosphorous levels in the blood, and those should be very helpful for kidney patients," says senior investigator Keith A. Hruska, M.D., the Ira M. Lang Professor of Nephrology and professor of pediatrics and of cell biology and physiology at Washington University School of Medicine in St. Louis. "The drug we used in the mice and other similar agents can treat both the phosphorous levels and skeletal weakening, and those drugs are just entering initial clinical trials."

The study will appear in the April issue of the Journal of the American Society of Nephrology.

Hruska, who is director of nephrology at St. Louis Children's Hospital, has long been interested in the connections between kidney damage and bone weakening. He and other researchers have uncovered a complex network of links between the skeleton and the kidney. Hormones made in the kidney regulate activity in the skeleton and vice-versa.

Last year, Hruska showed that injections of bone morphogenetic protein-7 (BMP-7) could prevent bone weakening in mice wh
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
29-Mar-2005


Page: 1 2 3

Related medicine news :

1. Mouse gene shows new mechanism behind cardiac infarction in man
2. Mouse model gives insight to human hair loss
3. Mouse study: Signal overload in Alzheimer brains
4. Mouse shows how Rituximab removes human B cells
5. Mouse study could aid vaccine designers
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... PHOENIX (PRWEB) , ... September 01, 2020 , ... ... of care for children with Pediatric Feeding Disorder (PFD), is pleased to announce that ... be a stand-alone diagnostic code (R code) in the next edition of the U.S. ...
(Date:8/31/2020)... ... 2020 , ... Cardiothoracic surgeons at Allegheny General Hospital (AGH), ... University (CMU) to develop a new heart monitoring device designed to serve as ... The AGH/CMU team was recently awarded a “Trailblazer” grant from the National Institutes ...
(Date:8/31/2020)... SPRINGS, Miss. (PRWEB) , ... August 31, 2020 ... ... Plus (GCPP) recently donated 1,400 N95 face masks to medical first responders across ... has continued to make donations of personal protective equipment (PPE) medical centers ...
(Date:8/31/2020)... ... 31, 2020 , ... Colorado State University Global (CSU Global) ... online education – is proud to announce its new master’s degree in ... kind in the nation, the 60-credit hour program is designed to provide students ...
(Date:8/31/2020)... ... ... for Covid-19 “PTS” with Mediation & Hypnosis , At this very turbulent time in ... deep anxiety, immense stress, and right now are needing serious relief from a constant state ... planet are experiencing a great degree of emotional discomfort, be it fear or worrying about ...
Breaking Medicine News(10 mins):
(Date:9/1/2020)... DENVER (PRWEB) , ... September 01, 2020 , ... ... has been appointed to serve as Secretary to the Board of Trustees ... , Mile High United Way is a Denver-based nonprofit organization that fights ...
(Date:8/31/2020)... ... ... you live in New York City you will always pay more for these two things: ... supply and demand, but are plastic surgeons in New York worth the premium prices that ... make the four-hour trip to have expert aesthetic treatments by some of the best doctors ...
(Date:8/28/2020)... ... August 28, 2020 , ... ... beauty, bringing a unique perspective and approach. Armed with her qualifications from Ross ... to share her knowledge of the human body with the nation and world. ...
Breaking Medicine Technology:
Cached News: