HOME >> MEDICINE >> NEWS
Mouse model reveals potential way to reduce cardiac deaths in kidney patients

St. Louis, March 29, 2005 -- Scientists have identified an important link between kidney damage and cardiac problems, creating new possibilities for treating the primary cause of death in kidney disease patients.

Researchers tracked a chain reaction that leads from kidney damage to weakening of the skeleton to increased phosphorous in the blood. They showed that higher phosphorous levels were directly linked to vascular calcification, a stiffening of the smooth muscle cells that line blood vessels. Vascular calcification leads to enlargement of one of the heart's four chambers, increased risk of congestive heart failure, heart attack and several other cardiac problems.

Mice treated with an experimental medication that alleviates the skeletal weakening brought on by kidney damage had normal phosphorous levels and decreased signs of vascular calcification.

"We already have treatments available that can control phosphorous levels in the blood, and those should be very helpful for kidney patients," says senior investigator Keith A. Hruska, M.D., the Ira M. Lang Professor of Nephrology and professor of pediatrics and of cell biology and physiology at Washington University School of Medicine in St. Louis. "The drug we used in the mice and other similar agents can treat both the phosphorous levels and skeletal weakening, and those drugs are just entering initial clinical trials."

The study will appear in the April issue of the Journal of the American Society of Nephrology.

Hruska, who is director of nephrology at St. Louis Children's Hospital, has long been interested in the connections between kidney damage and bone weakening. He and other researchers have uncovered a complex network of links between the skeleton and the kidney. Hormones made in the kidney regulate activity in the skeleton and vice-versa.

Last year, Hruska showed that injections of bone morphogenetic protein-7 (BMP-7) could prevent bone weakening in mice wh
'"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
29-Mar-2005


Page: 1 2 3

Related medicine news :

1. Mouse gene shows new mechanism behind cardiac infarction in man
2. Mouse model gives insight to human hair loss
3. Mouse study: Signal overload in Alzheimer brains
4. Mouse shows how Rituximab removes human B cells
5. Mouse study could aid vaccine designers
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/5/2020)... ... 2020 , ... In its often-heroic ongoing response to the ... the obstacle - shortages of tests, ventilators and ICU beds; strained lab capacity; ... of all nonessential services - providers across the country have found new and ...
(Date:8/5/2020)... , ... August 05, 2020 , ... CentrAlert, Inc. ... help everyone gain access to essential COVID-19 information. Know NOW!, which is available for ... COVID-19 updates and unify them in one easy-to-use mobile application. , “When COVID-19 first ...
(Date:8/5/2020)... ... August 04, 2020 , ... Today, Power to Decide’s One Key Question ... the 2020 Innovation Station Best Practice Award. The One Key Question program is a ... get pregnant and have a child. One Key Question is used by thousands of ...
(Date:8/3/2020)... (PRWEB) , ... August 03, 2020 , ... ... announced enrollment of the first patients with first-line advanced pancreatic cancer in a ... 1/2 1801 trial of 9-ING-41, (NCT03678883, EudraCT#:2018-003739-32). 9-ING-41 is Actuate’s proprietary small ...
(Date:7/31/2020)... ... July 31, 2020 , ... National Association of ... statement today regarding the nation’s ongoing preparations for the eventual deployment of COVID-19 ... an efficient, effective and essential component of vaccine deployment. They will need to ...
Breaking Medicine News(10 mins):
(Date:7/10/2020)... ... July 09, 2020 , ... The Urgent Care Association (UCA), College of ... collaborating to present a virtual education on acute flaccid myelitis (AFM), an uncommon but ... 1 p.m. CT on July 14, 2020. , AFM, which is most prevalent ...
(Date:7/7/2020)... , ... July 07, 2020 , ... ... its partnership with Psych Hub, the leading comprehensive platform for online education on ... to offer support resources to Substance Use Disorder (SUD) patients throughout each step ...
(Date:7/7/2020)... ... July 07, 2020 , ... To support those on the ... Change (WGC), will be providing meals to the employees of Southern Nevada Health District. ... throughout Las Vegas on Wednesday, July 8th. , When asked why the Women of ...
Breaking Medicine Technology:
Cached News: