HOME >> MEDICINE >> NEWS
Mouse provides clues about chronic pain

Investigators at Washington University School of Medicine in St. Louis have found that a protein that allows nerve cells to communicate may enhance perceptions of chronic and persistent pain. In the February issue of Nature Neuroscience, they report the protein, called NR2B, makes mice more aware of minor pain for longer periods of time.

"That sustained response appears to mimic what happens in people who experience pain long after the painful stimulus has disappeared," says principal investigator Min Zhuo, Ph.D., an associate professor of anesthesiology and of anatomy and neurobiology. "So interfering with NR2B in humans might be a strategy for treating chronic pain."

NR2B is one of the mix-and-match building blocks of important cellular proteins called NMDA receptors. Like radio receivers, these receptors sit on the cell surface, tuned in to messages sent from neighboring cells and carried by the chemical messenger glutamate. More importantly, NMDA receptors are a neurons activity detectors, and they function only when the number and intensity of neuronal messages reach a prescribed, threshold level.

Because NMDA receptors only become activated at these threshold levels, they tend to be the primary neuronal receptors involved in important brain functions such as learning and memory and in injurious brain processes such as stroke, head injury and drug abuse. They also are the primary receptors involved in persistent pain.

The researchers studied a strain of genetically altered mice that was created by Joe Tsien, Ph.D. and colleagues at Princeton University to make extra NR2B in forebrain areas. The Washington University group found that these mice reacted to acute pain in the same way as normal mice. But the NR2B mice seemed to have stronger or longer periods of behavioral responses to two different models of more persistent, inflammatory pain. None of the mice demonstrated pain symptoms in the absence of an injury.

"We believe that when an i
'"/>

Contact: Jim Dryden
drydenj@msnotes.wustl.edu
314-286-0110
Washington University School of Medicine
27-Jan-2001


Page: 1 2 3 4

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse study could aid vaccine designers
7. Mouse model mimics real-world plague infection
8. Mouse antibodies thwart SARS virus
9. Mouse model of neuromuscular disease identifies key player in motor neuron death
10. Mouse study gives new view of anthrax toxin
11. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse provides clues about chronic pain

(Date:8/22/2014)... Reacting to naysayers who are being skeptical about ... top PRP therapy LA specialist has firmly stated that ... with practical well researched science and nothing to do ... new medical breakthrough technology which focuses on healing and ... therapy. , The Managing Director of one of the ...
(Date:8/22/2014)... Columbus, OH (PRWEB) August 22, 2014 ... young people in Columbus, OH. Unfortunately, most young adults ... make a difference in the community, the new Troubled ... resource for adolescents seeking to overcome their drug and ... helpline at (614) 902-4644, teens and their parents can ...
(Date:8/22/2014)... August 22, 2014 Aid in Recovery, ... a statement today regarding a recent bill ... Samuel Pagdilao, a current legislator and retired police general. ... for drug related offenders, rather than imprisonment. Aid in ... a forward-thinking solution for the drug addiction epidemic. , ...
(Date:8/21/2014)... York (PRWEB) August 22, 2014 Yoga ... the Long Island region, proudly announces the launch of ... focused on the West Babylon-based yoga studio’s new teacher ... wish to become teachers realize their dreams. , Since ... and those living in the surrounding area a place ...
(Date:8/21/2014)... well-known wedding dress manufacturer, has added a new collection of ... addition to this, all these beautiful gowns are provided with ... moment. The special offer will last from this afternoon until ... updated its online category with these affordable, elegant outfits. It ... one stop place where worldwide people can buy all kinds ...
Breaking Medicine News(10 mins):Health News:MetroMD With The Help Of PRP Therapy Helps People Fight Hip Injuries 2Health News:New Helpline in Columbus Assists Troubled Teen Find Youth Rehab 2Health News:Proposed Legislature in the Philippines Highlights the Need for Rehabilitation, Not Incarceration, for Drug Users, Says Aid in Recovery 2Health News:Proposed Legislature in the Philippines Highlights the Need for Rehabilitation, Not Incarceration, for Drug Users, Says Aid in Recovery 3Health News:Yoga Darshana Center Announces Launch of New Website LongIslandYogaTeacherTraining.com 2Health News:Beautiful Peacock Party Dresses for 2014 Offered by UWDress.com at the Moment 2
(Date:8/21/2014)... FLORHAM PARK, N.J. , Aug. 21, 2014 ... specialty pharmacy group purchasing organization (GPO), is pleased ... (Aurora) to collaborate on a host of innovative ... will help Aurora deliver enhanced therapy management services ... Therapy Management (OTM) system. Aurora will ...
(Date:8/21/2014)... TORONTO , Aug. 21, 2014 /CNW/ - Bedrocan ... appointed three independent members to its Board of ... care experience of the company, a leading licensed ... . Internationally, Bedrocan has 13 years, experience ... patients in seven countries, including Canada. ...
(Date:8/21/2014)... 21, 2014   Auxilium Pharmaceuticals, Inc. ... company, today announced positive results from a randomized, ... (or CCH) for the treatment of edematous fibrosclerotic ... Phase 2a trial, all three doses of CCH ... an improvement in the appearance of cellulite as ...
Breaking Medicine Technology:Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 2Aurora Health Care Partners with Armada Health Care to Deliver Added Pharmacy Capabilities to Specialty Patients 3Senior Life Sciences Executives Join Bedrocan as Independent Directors 2Senior Life Sciences Executives Join Bedrocan as Independent Directors 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 2Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 3Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 4Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 5Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 6Auxilium Pharmaceuticals, Inc. Announces Positive Data From Phase 2a Study Of CCH In Patients With Cellulite 7
Cached News: