HOME >> MEDICINE >> NEWS
Mouse provides clues about chronic pain

Investigators at Washington University School of Medicine in St. Louis have found that a protein that allows nerve cells to communicate may enhance perceptions of chronic and persistent pain. In the February issue of Nature Neuroscience, they report the protein, called NR2B, makes mice more aware of minor pain for longer periods of time.

"That sustained response appears to mimic what happens in people who experience pain long after the painful stimulus has disappeared," says principal investigator Min Zhuo, Ph.D., an associate professor of anesthesiology and of anatomy and neurobiology. "So interfering with NR2B in humans might be a strategy for treating chronic pain."

NR2B is one of the mix-and-match building blocks of important cellular proteins called NMDA receptors. Like radio receivers, these receptors sit on the cell surface, tuned in to messages sent from neighboring cells and carried by the chemical messenger glutamate. More importantly, NMDA receptors are a neurons activity detectors, and they function only when the number and intensity of neuronal messages reach a prescribed, threshold level.

Because NMDA receptors only become activated at these threshold levels, they tend to be the primary neuronal receptors involved in important brain functions such as learning and memory and in injurious brain processes such as stroke, head injury and drug abuse. They also are the primary receptors involved in persistent pain.

The researchers studied a strain of genetically altered mice that was created by Joe Tsien, Ph.D. and colleagues at Princeton University to make extra NR2B in forebrain areas. The Washington University group found that these mice reacted to acute pain in the same way as normal mice. But the NR2B mice seemed to have stronger or longer periods of behavioral responses to two different models of more persistent, inflammatory pain. None of the mice demonstrated pain symptoms in the absence of an injury.

"We believe that when an i
'"/>

Contact: Jim Dryden
drydenj@msnotes.wustl.edu
314-286-0110
Washington University School of Medicine
27-Jan-2001


Page: 1 2 3 4

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse study could aid vaccine designers
7. Mouse model mimics real-world plague infection
8. Mouse antibodies thwart SARS virus
9. Mouse model of neuromuscular disease identifies key player in motor neuron death
10. Mouse study gives new view of anthrax toxin
11. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse provides clues about chronic pain

(Date:3/3/2015)... Burlington, VT (PRWEB) March 03, 2015 In ... world’s largest environmental networks, will kick off a new campaign, ... join the network’s businesses, nonprofits, and ambassadors in their quest ... Planet will work with several of its members and partners, ... Johnson’s All At Once network, to raise awareness for food ...
(Date:3/3/2015)... (PRWEB) March 04, 2015 The report ... on the therapeutic development for Alopecia. Alopecia is the ... the two main types of alopecia. Causes for alopecia ... Symptoms of alopecia may include male pattern hair loss, ... hair. Alopecia can be classified as focal or diffuse ...
(Date:3/3/2015)... (PRWEB) March 03, 2015 US Air ... efficiency air purification systems, is pleased to announce that all ... brief supply interruption related to the west coast port strikes. ... just around the corner. , The port ... expected to slow fourth quarter economic growth by as much ...
(Date:3/3/2015)... NY (PRWEB) March 03, 2015 Daylight Savings ... spring. Sanjeev Kothare, MD, has tips for parents. , Parents ... March 8 at 2:00 a.m. when they set their clocks ... you wake up that day -- one hour earlier -- ... That’s why parents should start thinking about “sleep hygiene” for ...
(Date:3/3/2015)... Topical BioMedics, Inc., announces its March Pain ... on Tuesday, March 10th, 12pm – 1pm and 4pm to ... 24/7. , The Pain Management Workshops are ... March 10th workshop is “Opioid Addiction: An Over-Medicated Society.” ... represents 5% of the world’s population, yet consumers 99% of ...
Breaking Medicine News(10 mins):Health News:1% For the Planet Asks Consumers to “Know Your Source” 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 2Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 3Health News:Alopecia Therapeutics Drugs and Companies Pipeline Market H1 2015 Review Report Available at RnRMarketResearch.com 4Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 2Health News:Rabbit Air Purifiers Back In Stock at US Air Purifiers LLC 3Health News:Don’t Let Daylight Savings Disrupt Your Child’s Sleep 2Health News:Topical BioMedics Hosts March Pain Management Webinar 2Health News:Topical BioMedics Hosts March Pain Management Webinar 3Health News:Topical BioMedics Hosts March Pain Management Webinar 4Health News:Topical BioMedics Hosts March Pain Management Webinar 5
(Date:3/3/2015)... - CPhI and P-MEC China 2015 ... Shanghai, China - The 15th CPhI ... at Shanghai New International Expo Center, on 24th June, 2015. ... and was introduced to China in 2001. It has successfully ... and global pharmaceutical industry over the past 15 years. With ...
(Date:3/3/2015)... NEW YORK , March 3, 2015 /PRNewswire/ ... biopharmaceutical company advancing protein biologic therapies and oncology supportive ... 27 th Annual ROTH Capital Partners Conference which ... Ritz-Carlton, Laguna Niguel in Dana Point, California.  ... is scheduled to present a corporate update on Wednesday, ...
(Date:3/3/2015)... Mar. 03, 2015 Research and Markets ... PharmaBiotech,s new report "Cardiovascular Drug Delivery - Technologies, ... Drug delivery to the cardiovascular system is ... anatomy and physiology of the vascular system; it supplies ... Drugs can be introduced into the vascular system for ...
Breaking Medicine Technology:15th Anniversary, Be Part of Chinese Pharma Dream 215th Anniversary, Be Part of Chinese Pharma Dream 3PlasmaTech Biopharmaceuticals To Present at 27th Annual ROTH Capital Partners Conference 2Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 2Global Cardiovascular Drug Delivery Technologies, Markets and Companies 2014-2024 3
Cached News: