HOME >> MEDICINE >> NEWS
Mouse provides clues about chronic pain

Investigators at Washington University School of Medicine in St. Louis have found that a protein that allows nerve cells to communicate may enhance perceptions of chronic and persistent pain. In the February issue of Nature Neuroscience, they report the protein, called NR2B, makes mice more aware of minor pain for longer periods of time.

"That sustained response appears to mimic what happens in people who experience pain long after the painful stimulus has disappeared," says principal investigator Min Zhuo, Ph.D., an associate professor of anesthesiology and of anatomy and neurobiology. "So interfering with NR2B in humans might be a strategy for treating chronic pain."

NR2B is one of the mix-and-match building blocks of important cellular proteins called NMDA receptors. Like radio receivers, these receptors sit on the cell surface, tuned in to messages sent from neighboring cells and carried by the chemical messenger glutamate. More importantly, NMDA receptors are a neurons activity detectors, and they function only when the number and intensity of neuronal messages reach a prescribed, threshold level.

Because NMDA receptors only become activated at these threshold levels, they tend to be the primary neuronal receptors involved in important brain functions such as learning and memory and in injurious brain processes such as stroke, head injury and drug abuse. They also are the primary receptors involved in persistent pain.

The researchers studied a strain of genetically altered mice that was created by Joe Tsien, Ph.D. and colleagues at Princeton University to make extra NR2B in forebrain areas. The Washington University group found that these mice reacted to acute pain in the same way as normal mice. But the NR2B mice seemed to have stronger or longer periods of behavioral responses to two different models of more persistent, inflammatory pain. None of the mice demonstrated pain symptoms in the absence of an injury.

"We believe that when an i
'"/>

Contact: Jim Dryden
drydenj@msnotes.wustl.edu
314-286-0110
Washington University School of Medicine
27-Jan-2001


Page: 1 2 3 4

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse study could aid vaccine designers
7. Mouse model mimics real-world plague infection
8. Mouse antibodies thwart SARS virus
9. Mouse model of neuromuscular disease identifies key player in motor neuron death
10. Mouse study gives new view of anthrax toxin
11. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2016)... Warner, New Hampshire (PRWEB) , ... May 26, 2016 , ... ... of which are designed, engineered, and manufactured in Warner, New Hampshire at the MadgeTech ... known to provide reliable monitoring solutions trusted by government agencies, including NASA. , ...
(Date:5/26/2016)... ... May 26, 2016 , ... In an effort to provide hair restoration information to the ... users and those who do not use the app. Dr. Mohebi, the founder of Parsa ... Dr. Mohebi Live . , Dr. Mohebi says, “The positive response to the Snapchat ...
(Date:5/26/2016)... , ... May 26, 2016 , ... The Lung ... host a six-week smoking cessation class starting June 6 at their clinic in downtown ... http://www.gnahec.org . , Additionally, the Lung Institute has created a free downloadable 4 Week ...
(Date:5/26/2016)... ... 26, 2016 , ... The MIAMI Institute for Age Management and Intervention celebrates ... MD, ABAARM. Dr. Adonis , Wellness Physician of the MIAMI Institute is certified ... Institute for Functional Medicine. , He also heads up FITTLab, the comprehensive medical testing ...
(Date:5/26/2016)... ... May 26, 2016 , ... OncLive® , ... National Cancer Institute-designated University of Virginia (UVA) Cancer Center to its ... editorial and marketing teams will publicize and promote public awareness of UVA Cancer ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... -- Cirujanos holandeses han puesto en marcha ... a compartir sus mejores prácticas por el mundo y ... de Europa, África, Asia y ... que combina la transmisión en vivo con mensajería instantánea ... Educación   "Imagine un médico de Medicines sans ...
(Date:5/24/2016)...  NxStage Medical, Inc. (Nasdaq: NXTM ), ... care, today announced that Jeffrey H. Burbank , ... schedule of investor conferences. Where applicable, a webcast of ... .   ... Friday, June 10, 2016 1:30 p.m. ET ...
(Date:5/24/2016)... KONG , May 24, 2016 /PRNewswire/ ... COMBO ™ , la première ... des cathéters destinés à l,intervention portant sur ... (FAV)   OrbusNeich, entreprise mondiale ... permettant de changer la vie, a élargi ...
Breaking Medicine Technology:
Cached News: