HOME >> MEDICINE >> NEWS
Mouse provides clues about chronic pain

Investigators at Washington University School of Medicine in St. Louis have found that a protein that allows nerve cells to communicate may enhance perceptions of chronic and persistent pain. In the February issue of Nature Neuroscience, they report the protein, called NR2B, makes mice more aware of minor pain for longer periods of time.

"That sustained response appears to mimic what happens in people who experience pain long after the painful stimulus has disappeared," says principal investigator Min Zhuo, Ph.D., an associate professor of anesthesiology and of anatomy and neurobiology. "So interfering with NR2B in humans might be a strategy for treating chronic pain."

NR2B is one of the mix-and-match building blocks of important cellular proteins called NMDA receptors. Like radio receivers, these receptors sit on the cell surface, tuned in to messages sent from neighboring cells and carried by the chemical messenger glutamate. More importantly, NMDA receptors are a neurons activity detectors, and they function only when the number and intensity of neuronal messages reach a prescribed, threshold level.

Because NMDA receptors only become activated at these threshold levels, they tend to be the primary neuronal receptors involved in important brain functions such as learning and memory and in injurious brain processes such as stroke, head injury and drug abuse. They also are the primary receptors involved in persistent pain.

The researchers studied a strain of genetically altered mice that was created by Joe Tsien, Ph.D. and colleagues at Princeton University to make extra NR2B in forebrain areas. The Washington University group found that these mice reacted to acute pain in the same way as normal mice. But the NR2B mice seemed to have stronger or longer periods of behavioral responses to two different models of more persistent, inflammatory pain. None of the mice demonstrated pain symptoms in the absence of an injury.

"We believe that when an i
'"/>

Contact: Jim Dryden
drydenj@msnotes.wustl.edu
314-286-0110
Washington University School of Medicine
27-Jan-2001


Page: 1 2 3 4

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse study could aid vaccine designers
7. Mouse model mimics real-world plague infection
8. Mouse antibodies thwart SARS virus
9. Mouse model of neuromuscular disease identifies key player in motor neuron death
10. Mouse study gives new view of anthrax toxin
11. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency

Post Your Comments:
*Name:
*Comment:
*Email:
TAG: Mouse provides clues about chronic pain

(Date:11/21/2014)... 2014 Saint Luke’s Mid America ... Guidelines®–Heart Failure Gold-Plus Quality Achievement Award for implementing ... Heart Association/American College of Cardiology Foundation in their ... Get With The Guidelines–Heart Failure is a quality ... most up-to-date, research-based guidelines with the goal of ...
(Date:11/21/2014)... November 21, 2014 Big Bud Farms ... upcoming episode of Innovations with Ed Begley Jr., airing ... times TBA. , Big Bud Farms, growers of legal ... harvesting, and utilization of medical marijuana. , This segment ... Farms’ wide variety of products for medicating. Viewers will ...
(Date:11/21/2014)... November 21, 2014 Recently, VogueQueen ... launched a wedding dress promotion for the coming holiday ... a special offer when checking out. , The beach ... 2014. The customers like the designs for the premium ... would not only be good for the environment, they ...
(Date:11/21/2014)... 2014 Midway through the research period ... (AIS) annual Directory of Health Plans, preliminary data shows ... of Health Plans is a comprehensive resource with enrollment ... the U.S. The 2015 edition will be ... Directory and Databases Division, the company’s exclusive in-house research ...
(Date:11/21/2014)... TruDenta, the creator of a diagnostic and ... jaw-related symptoms, has reported a nationwide rise in the ... neck pain, TMJ (temporomandibular joint) disorder, jaw pain, tinnitus, ... a 52% increase in the number of patients our ... and their teams in 47 states are changing lives ...
Breaking Medicine News(10 mins):Health News:Saint Luke’s Mid America Heart Institute Awarded Get With The Guidelines Heart Failure Gold-Plus Quality Achievement Award 2Health News:Saint Luke’s Mid America Heart Institute Awarded Get With The Guidelines Heart Failure Gold-Plus Quality Achievement Award 3Health News:Saint Luke’s Mid America Heart Institute Awarded Get With The Guidelines Heart Failure Gold-Plus Quality Achievement Award 4Health News:Big Bud Farms to be Featured in Upcoming Episode of Innovations with Ed Begley Jr. 2Health News:Beach Wedding Dresses on Sale for the Coming Holiday Season at VogueQueen.com 2Health News:Data from Atlantic Information Services’s Forthcoming Directory Shows Volatility in U.S. Health Care Market 2Health News:National Rise In Patients Seeking Headache Relief 2
(Date:11/21/2014)... , Nov. 20, 2014 /CNW Telbec/ - KLOX Technologies ... the following appointments: Todd Martensen ... the newly created role of Chief Commercial Officer, to ... using topical photoconverter gel for the treatment of chronic ... traumatic wounds, recently approved in Europe ...
(Date:11/21/2014)... -- Oxis International, Inc. (OXIS) (OXI.PA) announced today the resignation ... J. Cataldo as Chief Executive Officer, and Steven ... Ken Eaton resigned his positions as Chief Executive ... International, Inc. to pursue new opportunities. Mr. ... of Oxis International, Inc. Mr. Cataldo will continue to serve ...
(Date:11/18/2014)... , Nov. 18, 2014 Respiratory Motion and ... leading medical device and services providers in ... for Respiratory Motion,s innovative respiratory depression monitor, the ExSpiron™. ... IMI are working together to connect the clinical community ... long history of bringing innovative medical devices and new ...
Breaking Medicine Technology:KLOX Technologies announces executive appointments 2KLOX Technologies announces executive appointments 3KLOX Technologies announces executive appointments 4OXIS International, Inc. announces Changes in Management Team 2OXIS International, Inc. announces Changes in Management Team 3Prominent Japanese Med Device Provider to be Respiratory Motion's Exclusive Partner for World's #2 Medical Market 2Prominent Japanese Med Device Provider to be Respiratory Motion's Exclusive Partner for World's #2 Medical Market 3Prominent Japanese Med Device Provider to be Respiratory Motion's Exclusive Partner for World's #2 Medical Market 4
Cached News: