HOME >> MEDICINE >> NEWS
Mouse shows how Rituximab removes human B cells

The monoclonal antibody Rituximab has been approved for the treatment of non-Hodgkin's lymphoma since 1997, but how Rituximab disposes of the cancerous (and normal) B cells is unknown. Research in a new mouse model reported in The Journal of Experimental Medicine suggests that the drug works by triggering the removal of B lymphocytes by scavenger cells.

Antibodies like Rituximab can remove cells in a variety of ways, including killing cells directly, inducing cell suicide, or triggering killing by other immune cells and molecules. Rituximab binds to CD20, a protein found on the surface of all B lymphocytes. In humans it is difficult to analyze how this leads to the elimination of B lymphocytes as only small numbers of cells can be sampled from the blood.

To mimic the clinical situation, Thomas Tedder and colleagues treated mice with a panel of antibodies specific for mouse CD20 (Rituximab is an antibody that binds to human but not mouse B cells). The antibodies that were effective in removing B cells did so by allowing B cell recognition by specialized 'scavenger' immune cells known as macrophages, which carry antibody receptors on their surface.

Less than half of patients with lymphoma respond to anti-CD20 therapy, so drugs that increase the number of macrophages or levels of antibody receptors might improve the response to Rituximab.

The new insight into how CD20 antibodies remove B cells should allow the design of better therapies not only for lymphoma, but also autoimmune diseases caused by rogue self-reactive B cells (as in rheumatoid arthritis), in which CD20 antibody trials are already underway.


'"/>

Contact: Nickey Henry
henryn@rockefeller.edu
212-327-8366
Journal of Experimental Medicine
21-Jun-2004


Page: 1

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse study could aid vaccine designers
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/21/2020)... PAUL, Minn. (PRWEB) , ... May 21, 2020 ... ... a medical device manufacturer, announces its first milestone to deliver over one million ... just eight weeks. Summit Medical Face Shields meet the critical need for personal ...
(Date:5/21/2020)... ... 21, 2020 , ... Having the cushion of an already ... already gained ground with the inherited reputation of quality, innovation, and professionalism. The ... an effective way for the ingredients to become immediately available to the cells. ...
(Date:5/21/2020)... KENNESAW, Ga. (PRWEB) , ... May 21, 2020 , ... ... Representatives District 35, has been endorsed by Planned Parenthood Southeast Advocates (PPSEA). ... candidates who support family planning and the full range of reproductive health care. PPSEA ...
(Date:5/21/2020)... ... May 21, 2020 , ... ESO , the leading ... announced the findings of its 2020 ESO Fire Service Index . The Index ... versus fire-related calls, first apparatus turnout time and travel time, the most common property ...
(Date:5/21/2020)... ... 21, 2020 , ... Casenet® LLC today released TruCare 2020, ... management and utilization management at health insurance plans. Developed over two years with ... usability and automation upgrades to all of its existing features, introduces more system-to-system ...
Breaking Medicine News(10 mins):
(Date:5/28/2020)... NASHVILLE, Tenn. (PRWEB) , ... May 28, 2020 ... ... the care continuum, The Beryl Institute releases its latest white paper, Caring for ... examines evidence of successful patient experience practices in pediatric settings and highlights key ...
(Date:5/27/2020)... ... ... County, Dr. Anuj Shah , CHIROPRACTIC CARE, Bergen County, ... Jo , Morris County, Dr. Derek Ferguson ... Camden County, Dr. Krista King , Union County, ...
(Date:5/27/2020)... BOSTON (PRWEB) , ... May 27, 2020 , ... ... security and cloud solutions, has announced it will once again sponsor the American Heart ... for Good Champion. This will mark the third year the firm is sponsoring the ...
Breaking Medicine Technology:
Cached News: