HOME >> MEDICINE >> NEWS
Mouse study could aid vaccine designers

Investigators from the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health, have conducted studies in mice to gain a new picture of how the immune system's "killer" T cells are prompted to destroy infected cells. Their insights provide a blueprint for rational design of vaccines that induce desired T-cell responses.

The findings are published in this week's Science. "If we are correct, what we've found will put rational vaccine design on a firmer footing," says Jonathan Yewdell, M.D., Ph.D., who led the NIAID team.

T cells belong to the cellular arm of the immune system's two-pronged defense mechanism against foreign invaders--the other arm features blood-borne antibodies. Historically, vaccines aimed to stimulate antibody production in a bid to prevent specific diseases. More recently, scientists have begun to manipulate T cells to create vaccines effective against pathogens that antibodies alone cannot control. Such T-cell-inducing vaccines are being tested against infectious diseases such as HIV/AIDS and hepatitis and are being studied as treatments for certain cancers.

Once alerted to the presence of infected cells, resting T cells are "awakened" and begin to multiply rapidly. Then they zero in on and destroy infected cells while sparing uninfected ones. Rousing slumbering T cells is the job of dendritic cells, the sentinels of the immune system. Dendritic cells activate the T cells by displaying peptides--small pieces of virus or other foreign protein--on their surfaces. In a process called direct priming, dendritic cells generate these peptides by themselves after being infected by a virus. Alternatively, dendritic cells may first interact with other body cells that have been infected by a virus and then activate the T cells. This indirect route is called cross-priming.

Vaccines may exploit either route to T-cell priming, but scientists have not known enough about the mechani
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
27-May-2004


Page: 1 2

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse model mimics real-world plague infection
7. Mouse antibodies thwart SARS virus
8. Mouse model of neuromuscular disease identifies key player in motor neuron death
9. Mouse study gives new view of anthrax toxin
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/31/2020)... ... August 31, 2020 , ... Just found out your dear friend has cancer? , It’s hard ... or family member shares their diagnosis. Once the shock wears off, the questions and fears ... What are the best ways to help? Words are failing me. I’m scared. I want ...
(Date:8/31/2020)... ... August 31, 2020 , ... Colorado State ... high-quality, career-relevant, and affordable online education – is proud to announce its new ... the first of its kind in the nation, the 60-credit hour program is ...
(Date:8/31/2020)... ... August 31, 2020 , ... In an effort to give back to ... 10 percent of each hotel room booked with a special new rate code to ... Indiana (RMHC-CNI) , effective immediately. Donations will be applied to any room type, ...
(Date:8/28/2020)... ... 28, 2020 , ... Ernst & Young LLP (EY US) ... Of The Year® 2020 Florida Award finalist. Now in its 34th year, the ... growth and prosperity as they build and sustain successful businesses that transform our ...
(Date:8/28/2020)... ... 28, 2020 , ... Integrated Viral Protection (IVP Air) today announced ... deploy its breakthrough Mobile Biodefense Indoor Air Protection System that is the first system ... to fully reopen equipped with the filtration system on September 8th. , The ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... September 03, 2020 , ... Sickle ... in September by holding a series of events and supporting the events of ... attention on the need for research and treatment of sickle cell disease. , ...
(Date:9/3/2020)... ... September 03, 2020 , ... Q&J Face Masks announced today ... aerosol and engineering lab, conducted tests on Q&J’s personal face mask that indicated ... many other masks. Q&J face masks have both mechanical filtering and electrostatic filtering ...
(Date:9/3/2020)... ... , ... Using Analysis of Variance — A Practical Approach:, Perform Statistical Analysis ... EDT, https://www.fdanews.com/anova , How much would it help one’s Quality Management System ... in 90 minutes, one can master a powerful statistical technique in that time — ...
Breaking Medicine Technology:
Cached News: