HOME >> MEDICINE >> NEWS
Mouse study gives new view of anthrax toxin

A large-scale study of anthrax in mice has yielded new information about immune system response to anthrax bacteria, according to scientists at the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health. The discovery that toxins released by the bacteria do not behave as previously believed should redirect approaches to anthrax drug design, notes NIAID Senior Investigator Stephen Leppla, Ph.D., whose research is published in today's issue of the Journal of Clinical Investigation.

In the new study, Dr. Leppla and his colleagues injected hundreds of inbred mice with anthrax lethal toxin (LT), and then took precisely timed measurements to determine how various organs and immune system processes responded. For example, they measured levels of chemicals called cytokines, which are released by immune system cells after a bacterial invasion. Dr. Leppla and his colleagues found no evidence of a persistent increase in cytokines, or of a link between cytokine increase and anthrax LT effects, contradicting earlier beliefs.

The evidence suggests that current efforts to design cytokine-suppressing drugs to treat lethal toxin-mediated events in late stages of anthrax may be misguided. "Finding effective therapies for diseases such as inhalational anthrax depends on our ability to connect basic research with clinicians' needs. This research is a perfect example of such translational research," says NIAID Director Anthony S. Fauci, M.D.

"Science has had a good understanding of anthrax toxins at molecular and subcellular levels," says Dr. Leppla. "What has been lacking is a picture of the much more complex effects of toxins on tissues and animal models. Ours is one of the first comprehensive studies to critically examine what is actually happening at these higher levels of complexity."

In a natural infection, inhalational anthrax begins after anthrax bacteria spores enter the body, germinate and rel
'"/>

Contact: Anne A. Oplinger
aoplinger@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
2-Sep-2003


Page: 1 2

Related medicine news :

1. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
2. Mouse gene shows new mechanism behind cardiac infarction in man
3. Mouse model gives insight to human hair loss
4. Mouse study: Signal overload in Alzheimer brains
5. Mouse shows how Rituximab removes human B cells
6. Mouse study could aid vaccine designers
7. Mouse model mimics real-world plague infection
8. Mouse antibodies thwart SARS virus
9. Mouse model of neuromuscular disease identifies key player in motor neuron death
10. Mouse studies reveal immune mechanism involved in bone loss caused by estrogen deficiency
11. Mouse provides clues about chronic pain

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:5/26/2020)... Mass. (PRWEB) , ... May 26, 2020 , ... Today ... Self-Assessment , a free online tool that will help business owners and leaders assess ... reopen and ramp up. This latest offering from TRC is intended to assist business ...
(Date:5/26/2020)... ... May 26, 2020 , ... As ... centers across the United States are joining forces to start a country-wide movement ... worked tirelessly to save lives. #FitForTheFrontLine is a national fitness challenge beginning Tuesday, ...
(Date:5/21/2020)... Va. (PRWEB) , ... May ... ... An Interactive Companion to the CRC’s Guide to Coordinating Clinical Research, CenterWatch ... of clinical research management, The CRC Trainer: An Interactive Companion to the ...
(Date:5/21/2020)... Minn. (PRWEB) , ... May 21, 2020 , ... ... medical device manufacturer, announces its first milestone to deliver over one million FDA-compliant ... eight weeks. Summit Medical Face Shields meet the critical need for personal protective ...
(Date:5/21/2020)... ... May 21, 2020 , ... Having ... of GSCG, VITA NOVAS has already gained ground with the inherited reputation of ... stimulating biological products intravenously, guaranteeing an effective way for the ingredients to become ...
Breaking Medicine News(10 mins):
(Date:5/21/2020)... ... May 21, 2020 , ... Today Anyblock ... of the Corona SeroStatus app. Many facilities, cities, states/provinces, and countries are eager ... of coronavirus globally—including nearly 1.5 million in the United States alone—serious concerns remain ...
(Date:5/21/2020)... ... 21, 2020 , ... In celebration of Nurses Month, ... set of retail offers and recognized a dedicated group of backers—all collaborating to ... PPE units have arrived to hospitals through commercial, government, and charity efforts, hundreds ...
(Date:5/16/2020)... Pa. (PRWEB) , ... May ... ... licensed allied healthcare professionals, who in collaboration with a physician, can provide ... examination and clinical diagnosis, therapeutic intervention, and rehabilitation of injuries and medical ...
Breaking Medicine Technology:
Cached News: