HOME >> MEDICINE >> NEWS
Multi-center study finds therapy boosts kidney transplants in 'highly sensitized' patients

LOS ANGELES (Dec. 8, 2004) Although transplantation is by far the preferred treatment option for patients with end-stage renal disease (ESRD), those with high levels of "anti-donor" antibodies have had little hope of receiving a donated organ. Among the relatively few who have undergone transplantation, rejection rates have been very high.

Because the immune systems of "highly sensitized" individuals initiate a rejection response against the tissue of the majority of the population, these patients typically spend the rest of their lives undergoing kidney dialysis several times a week a painful, costly process that extends life but usually results in a diminishing quality of life.

Now, a 12-center study, funded in part by the National Institutes of Health and reported in the December 2004 issue of the Journal of the American Society of Nephrology, found that an immune-modulating therapy pioneered for transplant patients at Cedars-Sinai Medical Center reduced high antibody levels and improved transplantation rates. The analysis was based on the experiences of 98 highly sensitized patients who were administered either the medication, called intravenous immunoglobulin (IVIG), or a placebo while awaiting transplantation.

"The study showed that there was a significant benefit of IVIG over placebo. In fact, the rates of transplantation for the IVIG group were more than double that for the placebo group. And for patients who had had a previous transplant which is a very big risk factor for not being able to have another one the IVIG group's transplant rate was triple that of patients on placebo," said Stanley C. Jordan, MD, director of Pediatric Nephrology & Transplant Immunology and medical director of the Renal Transplant Program at Cedars-Sinai.

"Most other anti-rejection drugs can make the patient more susceptible to infectious complications because they are globally immunosuppressive," said Dr. Jordan, the study's principal i
'"/>

Contact: Sandra Van
sandy@vancommunications.com
1-800-880-2397
Cedars-Sinai Medical Center
8-Dec-2004


Page: 1 2 3

Related medicine news :

1. Multi-center study shows direct link between residential radon exposure and lung cancer
2. Multi-center trial compares three medications in patients with heart failure
3. First head-to-head study to compare lidoderm patch and Celebrex in treating pain
4. UMaine study looks at infants and chronic nighttime crying
5. Chronic pain treatments more effective when taken together, new study shows
6. UNC study: Most N.C. family practitioners engage in unrecognized community service
7. New study in Nature demonstrates protection against cell death during heart attack
8. UCSF study offers insight into human circadian rhythms
9. International breast cancer prevention study launches in the United States and Canada
10. UW study shows blacks and Latinos are more satisfied with physicians of the same race
11. Physicians may not be accurate in their confidence levels of their diagnoses, says Pitt study

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/23/2020)... (PRWEB) , ... January 23, 2020 , ... ... IRF Executive Committee and the IRF Board of Trustees. Representing all segments of ... foundation in meeting its mission of conducting research and providing education highlighting the ...
(Date:1/23/2020)... ... January 23, 2020 , ... NowRx , the ... Orange County today with the grand opening of its state-of-the-art, 4,500 square foot, ... time of a traditional pharmacy. NowRx uses an eco-friendly fleet of delivery ...
(Date:1/22/2020)... (PRWEB) , ... January 22, ... ... that provides hearing, speech, and education services, recently appointed Ilana Glazer as ... communications, and outreach initiatives. Specifically, Ilana directs donor relations, grants administration, external ...
(Date:1/22/2020)... ... January 22, 2020 , ... Dr. Mario ... band can be for reducing food intake, enabling sustainable weight loss and improving ... while bariatric surgery may be a great tool for achieving significant weight loss, ...
(Date:1/12/2020)... ... January 11, 2020 , ... The co-founder and CEO of ... with the annual JP Morgan Healthcare Conference. On Sunday, January 12, Sujuan Ba, ... technology company investors and advisers at the San Francisco office of international law ...
Breaking Medicine News(10 mins):
(Date:1/24/2020)... ... January 24, 2020 , ... The American College of ... a systematic reform of the health care system. Recently, practicing internist and President of ... of Governmental Affairs and Public Policy at ACP, teamed with YourUpdateTV to discuss how ...
(Date:1/23/2020)... ... January 23, 2020 , ... ... assisted living community, has received a deficiency-free survey in 2019 as administered ... receive a deficiency-free survey from the State,” said Glen Cummins Regional Director of ...
(Date:1/23/2020)... ... January 23, 2020 , ... As Sarasota’s older population surges, ... want to stay in their own homes, according to The American Association of Retired ... care . Now, affluent seniors seeking truly professional caregivers have a new option -- ...
Breaking Medicine Technology:
Cached News: