HOME >> MEDICINE >> NEWS
Muscular dystrophy mouse model yields potential growth factor treatment

An altered mouse model of Duchenne muscular dystrophy, developed to have high levels of insulin-like growth factor I (IGF-I), has shown increases in muscle mass of at least 40 percent and other changes that could herald a possible treatment for secondary symptoms of the disease in humans. The new mouse, developed with support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the Muscular Dystrophy Association, has also resulted in reduced amounts of muscle-replacing fibrous tissue and enhanced biological pathways associated with muscle regeneration.

Duchenne muscular dystrophy, a genetic muscle-wasting disease caused by mutations in the gene for the protein dystrophin, results in repeated cycles of muscle damage and insufficient muscle regeneration, leading to gradual replacement of muscle by fibrous tissue. Since IGF-I is known to help regenerate muscle and enhance biological pathways for making proteins, the University of Pennsylvania's H. Lee Sweeney, M.D., and his colleagues tested its effects by creating a new mouse model a cross between a strain with muscular dystrophy symptoms and another with high levels of IGF-I. The hybrid mouse showed not only increases in muscle mass and muscle force generation, but also reduced muscle cell death, a combination that could have significant treatment implications.

"This is indeed good news for the muscular dystrophy community," said Stephen I. Katz, M.D., Ph.D., director of NIAMS. "The mouse model has helped our efforts against this disease more than once, and it looks like the search for answers has moved to another level."

The new mouse model offers an additional potential benefit, says Dr. Sweeney. "The combination of better muscle regeneration and less muscle wasting could lead to a better muscle capacity over time.

Less muscle effort would be needed to produce a required force, s
'"/>

Contact: Ray Fleming
flemingr@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
22-May-2002


Page: 1 2

Related medicine news :

1. McCaw/Muscular Dystrophy Association fund supports UW recruitment of internationally noted gene therapy researcher
2. Mayo Clinic researchers identify new form of muscular dystrophy in adults
3. New guideline: Corticosteroids recommended for duchenne muscular dystrophy
4. New centers boost muscular dystrophy research
5. Muscle stem cells show promise against muscular dystrophy in mouse model
6. Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy
7. University of Pittsburgh researcher provides first-ever definition of HIV-associated lipodystrophy
8. UT Southwestern to study lipodystrophy syndrome in HIV-infected patients
9. UI study identifies mechanism that causes cardiomyopathy, exacerbates muscular dystrophy
10. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
11. UCSD-Utah team develops mouse model to test therapies for macular degeneration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:6/24/2016)... ... June 24, 2016 , ... Puradigm® & Innovative ... has initiated cultivation and processing operations at its production facility, and opened its ... Puradigm is the manufacturer of a complete system of proactive air and surface ...
(Date:6/24/2016)... ... 24, 2016 , ... Advanced Plastic Surgery Institute ( http://www.advancedplasticsurgeryinstitute.com ... its official Medspa Sponsor. Dr. Josh Olson, a board-certified plastic surgeon, owns the ... Olson says the decision to support the pageant in an official capacity is ...
(Date:6/24/2016)... ... ... SpiritQuest Sedona Retreats, located in Arizona has re-located to 75 Kallof Place, Suite ... Airport Mesa, and Boynton Canyon. The new retreat center is ideally-situated within ... Sedona Rouge, both popular accommodations for SpiritQuest clients. The Medicine Wheel, Labyrinth and ...
(Date:6/23/2016)... (PRWEB) , ... June 23, 2016 , ... The Mechille ... business clients throughout Jasper County and the surrounding region, is initiating a charity drive ... drive will raise funds earmarked for a scholarship fund that will be presented to ...
(Date:6/23/2016)... , ... June 23, 2016 , ... ... Court ruling a victory for consumers seeking relief from the crushing burden of ... A2913-15T2 & A2929-15T2. , In their ruling ( http://www.judiciary.state.nj.us/opinions/a2913-15a2929-15.pdf ) the ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 ... Oticon , industry leaders in advanced ... launch of Oticon Opn ™, the world,s first ... of possibilities for IoT devices.      (Photo: ... Oticon introduces a number of ,world firsts,: ...
(Date:6/23/2016)... , June 23, 2016 The vast majority ... outpatient dialysis facility.  Treatments are usually 3 times a ... per visit, including travel time, equipment preparation and wait ... but especially grueling for patients who are elderly and ... skilled nursing and rehabilitation centers for some duration of ...
(Date:6/23/2016)... 2016  Experian Health, the healthcare industry ... patient payment and care experience, today announced ... and services that will enhance the breadth ... These award-winning solutions will enable healthcare professionals ... in an ever-changing environment and redefine front-office ...
Breaking Medicine Technology:
Cached News: