HOME >> MEDICINE >> NEWS
Muscular dystrophy mouse model yields potential growth factor treatment

An altered mouse model of Duchenne muscular dystrophy, developed to have high levels of insulin-like growth factor I (IGF-I), has shown increases in muscle mass of at least 40 percent and other changes that could herald a possible treatment for secondary symptoms of the disease in humans. The new mouse, developed with support from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) and the Muscular Dystrophy Association, has also resulted in reduced amounts of muscle-replacing fibrous tissue and enhanced biological pathways associated with muscle regeneration.

Duchenne muscular dystrophy, a genetic muscle-wasting disease caused by mutations in the gene for the protein dystrophin, results in repeated cycles of muscle damage and insufficient muscle regeneration, leading to gradual replacement of muscle by fibrous tissue. Since IGF-I is known to help regenerate muscle and enhance biological pathways for making proteins, the University of Pennsylvania's H. Lee Sweeney, M.D., and his colleagues tested its effects by creating a new mouse model a cross between a strain with muscular dystrophy symptoms and another with high levels of IGF-I. The hybrid mouse showed not only increases in muscle mass and muscle force generation, but also reduced muscle cell death, a combination that could have significant treatment implications.

"This is indeed good news for the muscular dystrophy community," said Stephen I. Katz, M.D., Ph.D., director of NIAMS. "The mouse model has helped our efforts against this disease more than once, and it looks like the search for answers has moved to another level."

The new mouse model offers an additional potential benefit, says Dr. Sweeney. "The combination of better muscle regeneration and less muscle wasting could lead to a better muscle capacity over time.

Less muscle effort would be needed to produce a required force, s
'"/>

Contact: Ray Fleming
flemingr@mail.nih.gov
301-496-8190
NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases
22-May-2002


Page: 1 2

Related medicine news :

1. McCaw/Muscular Dystrophy Association fund supports UW recruitment of internationally noted gene therapy researcher
2. Mayo Clinic researchers identify new form of muscular dystrophy in adults
3. New guideline: Corticosteroids recommended for duchenne muscular dystrophy
4. New centers boost muscular dystrophy research
5. Muscle stem cells show promise against muscular dystrophy in mouse model
6. Enzyme halts muscle waste in mouse models of most-common childhood muscular dystrophy
7. University of Pittsburgh researcher provides first-ever definition of HIV-associated lipodystrophy
8. UT Southwestern to study lipodystrophy syndrome in HIV-infected patients
9. UI study identifies mechanism that causes cardiomyopathy, exacerbates muscular dystrophy
10. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
11. UCSD-Utah team develops mouse model to test therapies for macular degeneration

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:12/2/2016)... , ... December 02, 2016 , ... ... announces the launch of its 60-day free trial program for all of the ... make the offer a truly hassle free experience. , FlexiSpot’s unique desktop risers ...
(Date:12/2/2016)... ... ... U.S. Surgeon General, Dr. Vivek Murthy, graces the cover of the print ... to practice medicine at an early age by his father, who was also a ... prescribing medicine,” he states. “It is about building relationships with people; relationships that are ...
(Date:12/2/2016)... ... December 02, 2016 , ... Dr. ... will be included in the 2016 “Guide to America’s Top Plastic Surgeons” for ... the amalgamation of their education, experience, and professional associations. , One the ...
(Date:12/2/2016)... ... December 02, 2016 , ... CloudLIMS.com, a class-leading provider ... CloudLIMS Lite. CloudLIMS Lite helps biobanks, clinical, research and testing laboratories keep track ... The new version is a faster and a more efficient product, allowing batch ...
(Date:12/2/2016)... (PRWEB) , ... December 02, 2016 , ... Sourced from ... has some unique properties including its unmatched natural purity of just 6 ppm TDS ... and crisp. , Nothing Water has been available in several ShopRite and FoodTown stores ...
Breaking Medicine News(10 mins):
(Date:12/2/2016)... Research and Markets has announced the addition of the "Global Ultrasound ... report to their offering. ... The global ultrasound device market accounted ... grow at a CAGR of 5.5% during 2016-2022. Based on portability, the ... period, a CAGR of 8.8% in the global market. Among the various ...
(Date:12/2/2016)... 2016 On Thursday, December 1st ... in research, development and innovation in the biopharmaceutical industry ... held in the presence of Sergey Tsyb, Vice Minister ... Federation , Natalia Sanina, First Vice Chairman of ... Head of Roszdravnadzor, National Service of Control in Healthcare, ...
(Date:12/2/2016)... R.I. , Dec. 2, 2016 CVS ... its annual Analyst Day in New York City on Thursday, December 15, ... CVS Health leadership team will provide an in-depth review ... enhance shareholder value. The company will also discuss 2017 ... and video webcast of the event will be broadcast ...
Breaking Medicine Technology:
Cached News: