HOME >> MEDICINE >> NEWS
Mycophenolate mofetil superior to azathioprine: Slows vascular disease progression after transplant

Researchers reported today that patients treated with CellCept (mycophenolate mofetil), a drug used to prevent rejection in organ transplantation, have significantly lower progression of intimal thickening, or thickening of the inner artery walls, compared with azathioprine (AZA). Intimal thickening is becoming increasingly important as a surrogate marker for long-term outcomes after heart transplantation. The study used intravascular ultrasound (IVUS) to measure intimal thickening in heart transplant patients immediately after surgery and one year later.

"These findings support published registry data that show significantly increased survival rates in CellCept-treated patients at three years," said Jon A. Kobashigawa, M.D., professor of medicine at the University of California, Los Angeles, Medical Center, and lead investigator of the study.

"Intimal thickening, as measured by IVUS, is a key indicator of vascular disease progression. These important data therefore confirm that heart transplant patients treated with CellCept have significantly less progression of intimal thickening than those treated with AZA. The prospect of achieving better long-term outcomes by slowing the progression of vascular disease is a significant benefit for transplant patients and the surgeons who treat them."

In the CellCept-treated group, only 23% of patients had an increase in intimal thickness of > 0.3mm versus 43% of patients treated with AZA. Studies have shown that patients with changes in intimal thickening of more than 0.3mm are more likely to have poor outcomes, such as myocardial infarction, organ failure and death.

Presented at the International Society for Heart and Lung Transplantation scientific sessions, the study used a more modern and clinically relevant site-to-site IVUS analysis of heart transplant patients to reanalyze intimal thickness in patients in the pivotal CellCept trial published in 1998.

The an
'"/>

Contact: Lauren Mason
masonpr@satx.rr.com
210-857-2521
International Society for Heart and Lung Transplantation
21-Apr-2004


Page: 1 2

Related medicine news :

1. Tacrolimus + mycophenolate mofetil & steroids: Safe, effective in preventing acute cardiac rejection
2. Kinder, gentler procedure gives superior results for stem cell transplants
3. Therapy, medication combination superior for children with obsessive-compulsive disorder
4. Universit de Montral study shows superior sound-location skills in the blind
5. CellCept(R) registry data demonstrated superior long-term organ transplant outcomes
6. Wavefront LASIK demonstrated superior to conventional LASIK
7. Transvaginal ultrasound superior to transrectal ultrasound for staging rectal cancer in women
8. MRI superior to ultrasound in predicting cerebral palsy in preterm infants
9. Linezolid is superior treatment for drug-resistant pneumonia
10. PET scans superior in revealing response to treatment for gastrointestinal stromal tumors
11. Endovascular coil superior to neurosurgery for treatment of brain haemorrhage

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:8/3/2018)... ... August 03, 2018 , ... ... 2001. Gerry Newlove first started the Firstaid4sport business in the 1990's and his ... remains one of the leading providers in the UK of sports medicine products, ...
(Date:8/3/2018)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has written a ... only to be understood in this current generation. Yisrayl says he has spent his ... he says scholars have struggled with for generations. Yisrayl says the meanings that he ...
(Date:8/2/2018)... , ... August 02, 2018 , ... Dr. Srini ... and brain biology of why some people could care less, demonstrating a “whatever” attitude ... there are many reasons for this, one often overlooked reason relates to being overworked. ...
(Date:8/2/2018)... ... August 02, 2018 , ... ... premium Resona 7 Ultrasound system with unique new upgrades at the Society of ... Based on ZONE Sonography® Technology (ZST), the upgrades include a unique arterial stiffness ...
(Date:8/2/2018)... STAMFORD, Conn. (PRWEB) , ... August 02, 2018 ... ... (TGA) to its prestigious Top 20 Training Delivery Companies of 2018 ... , “Our mission is to empower training industry professionals with the game-based tools ...
Breaking Medicine News(10 mins):
(Date:8/2/2018)... Md. (PRWEB) , ... August 02, 2018 , ... ... may have concerns about their child’s ability to communicate. These may include concerns ... treatment in schools by a speech-language pathologist. Here’s what parents should ...
(Date:8/2/2018)... ... 2018 , ... Shady Grove Fertility (SGF), a ... into Florida with the opening of a location in Tampa through ... health care throughout Central Florida. This is SGF’s first location in the Sunshine ...
(Date:8/2/2018)... ... ... Fitness Machine Technicians, specialists in the maintenance and repair of exercise equipment for ... Charlotte area. The business will be lead by Cornelius, NC resident Todd Armstrong. ... fitness is a big business – residents like me rely on fitness centers and ...
Breaking Medicine Technology:
Cached News: