HOME >> MEDICINE >> NEWS
Myosin mutant points to human origins

(Philadelphia, PA) In an effort to find the remaining genes that govern myosin--the major contractile protein that makes up muscle tissue--researchers at the University of Pennsylvania School of Medicine have made a discovery that may be central to answering key questions about human evolution.

Published in the March 25 issue of Nature, Penn researchers have found one small mutation that undermines an entire myosin gene. Their estimated dating for the appearance of this mutation places it at about 2.5 million years ago, just prior to a period of major evolutionary changes in the hominid fossil record. These include the beginning of larger brain size, so important in making us human. While the characterization of this mutation may better help understand such genetic diseases as muscular dystrophy, this finding has potentially wider implications for re-interpreting long-held notions about the appearance and early evolution of the genus Homo.

Anthropologists have long debated how humans evolved from ancestors with larger jaw muscles and smaller brains. This newly discovered mutation seems responsible for the development of smaller jaw muscles in humans as compared to non-human primates. These converging lines of evidence suggest the question: Did this genetic mutation lift an evolutionary constraint on brain growth in early humans?

In a classic case of scientific sleuthing, Hansell Stedman, M.D., Associate Professor of Surgery, Nancy Minugh-Purvis, Ph.D., Director of Advanced Gross Anatomy, Department of Cell and Developmental Biology, and colleagues took their discovery of a mutation that prevents the expression of a variety of myosin -- designated MYH16 on chromosome 7 -- to its ultimate context: what makes humans different from other primates.

"Around the lab, we jokingly call this the 'room for thought' mutation, since we had to involve scientists from several disciplines to make sense of the possible domino effects," says Stedman. "In
'"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
24-Mar-2004


Page: 1 2 3 4

Related medicine news :

1. Myosin molecule walks like a person, experiment shows
2. Targeting mutant B-Raf protein reduces melanoma development
3. First mouse model for multiple system atrophy points to new treatment targets for brain diseases
4. Brain imaging study of drunk drivers pinpoints neurological changes
5. Study pinpoints schizophrenia brain glitch
6. Technology points to possible targets for epilepsy and Alzheimers drugs
7. Majority of authors retract 1998 Lancet paper-Lancet editor points to implications
8. Understanding Alzheimers disease: Animal research points to new direction for therapy
9. Benchmark study of brain tumors points to resection over biopsy as one key to survival
10. Study points to long-term health problems for pediatric cancer survivors
11. Research pinpoints variations in sit-up techniques

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:9/1/2020)... GLENDALE, Calif. (PRWEB) , ... September 01, 2020 ... ... opened a new practice in Glendale. While the office will be ... procedures as breast augmentation, tummy tucks, buttock augmentation (Brazilian butt lift), as well ...
(Date:9/1/2020)... ... September 01, 2020 , ... Dr. Kiran Gill ... aesthetic surgery of the face, breast, and body. In 2018, she founded Aesthetics ... plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill and her team ...
(Date:8/31/2020)... SPRINGS, Miss. (PRWEB) , ... August 31, 2020 ... ... Plus (GCPP) recently donated 1,400 N95 face masks to medical first responders across ... has continued to make donations of personal protective equipment (PPE) medical centers ...
(Date:8/31/2020)... ... 2020 , ... Smile Brands Inc., one of the nation’s ... today announced the grand opening of another affiliated Bright Now! Dental office ... hours, a comfortable office, and full-service care at the new Beaumont location. The ...
(Date:8/31/2020)... ... 2020 , ... Dr. Chang has over 20 years of ... developmental disabilities, as well as supporting staff in caring for patients and families. ... and staff development. She joined the company in 2015 as Chief of Clinical ...
Breaking Medicine News(10 mins):
(Date:9/3/2020)... ... 2020 , ... Using Analysis of Variance — A Practical Approach:, Perform Statistical ... p.m. EDT, https://www.fdanews.com/anova , How much would it help one’s Quality Management ... one in 90 minutes, one can master a powerful statistical technique in that time ...
(Date:9/1/2020)... CLARA, Calif. (PRWEB) , ... September 01, 2020 ... ... and analytical laboratory technologies, will host the Agilent Science and Technology Virtual ... During this two-day symposium, Agilent will open a suite of Live webinars and ...
(Date:9/1/2020)... ... , ... September is National Ovarian Cancer Awareness Month. Ovarian cancer is ... of the female reproductive system. The American Cancer Society estimates that in 2020, ... die from this disease. Throughout the month of September, Women’s Excellence aims to ...
Breaking Medicine Technology:
Cached News: