HOME >> MEDICINE >> NEWS
NHLBI Clinical Trial Stopped Early: Successful Ventilator Strategy Found For Intensive Care Patients On Life Support

The National Heart, Lung, and Blood Institute of the National Institutes of Health today announced that a large clinical trial of mechanical ventilator use for intensive care patients with Acute Respiratory Distress Syndrome (ARDS) has been stopped early. The decision was recommended by the study's Data Safety and Monitoring Board (DSMB) on March 10, 1999, based on data on the first 800 patients which showed approximately 25 percent fewer deaths among patients receiving small, rather than large, breaths of air from a mechanical ventilator.

The ARDS Network Study of Ventilator Management in ARDS, scheduled to end late in 1999, was stopped early so that critical care specialists could be alerted to the results.

According to NHLBI Director Dr. Claude Lenfant, "This is the first large clinical trial to demonstrate a more effective treatment for ARDS patients. The findings will improve the care of these patients and save thousands of lives each year."

ARDS is a devastating, often fatal, inflammatory lung condition that usually occurs in conjunction with catastrophic medical conditions, such as pneumonia, shock, sepsis, and trauma. Approximately 150,000 Americans are affected each year, and more than 40 percent die.

No specific therapies currently exist for these patients. Treatment involves supportive care in an intensive care unit (ICU), including use of a mechanical ventilator and supplemental oxygen to help patients breathe.

The ARDS study was designed to compare the safety and efficacy of two different methods of setting the ventilator. After informed consent was obtained, patients were randomly assigned to receive either relatively large (12 ml/kg) or small (6 ml/kg) breaths of air from the ventilator. The initial plan for the study, which began in 1996, was to enroll 1,000 patients, ages 18 and older.

Mechanical ventilators deliver breaths of oxygen-enriched air to the body an
'"/>

Contact: Ellen Sommer
sommere@gwgate.nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung, and Blood Institute
15-Mar-1999


Page: 1 2

Related medicine news :

1. NHLBI study shows smoking cessation programs improve survival
2. Frequent fast food meals increase weight, diabetes risk, NHLBI study says
3. NHLBI statement on oral contraceptive study
4. NHLBI stops sickle cell anemia transfusion study
5. Statement from Barbara Alving of NHLBI on guidelines for cardiovascular disease prevention in women
6. Former NHLBI director Lenfant receives Lifetime Achievement Award
7. NHLBI study finds hostility, impatience increase hypertension risk
8. NHLBI study finds moderate physical activity promotes weight loss as well as intense exercise
9. NHLBI funds new heart-health education projects in high-risk communities
10. NHLBI study shows weight concerns increase girls risk of becoming smokers
11. NHLBI study shows vast majority of middle-aged Americans at risk of developing hypertension

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:10/13/2017)... ... October 13, 2017 , ... Lori R. Somekh, founder of the ... national organization of elder law and special needs planning attorneys. “Membership in ElderCounsel helps ... provides a forum to network with elder law attorneys nationwide,” said Somekh. , ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
(Date:10/13/2017)... York, NY (PRWEB) , ... October 13, 2017 , ... ... influential people in business to advocate for action towards gender equality at their inaugural ... views from around the globe, and reached a social audience of over 3 million. ...
(Date:10/13/2017)... ... 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House of ... popular and least understood books in the Holy Scriptures, Revelation. The Book of Revelation ... scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl Hawkins ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/10/2017)... received FDA 510(k) clearance in May 2017 for its highly anticipated ... for endoscopy environments. An innovative secondary monitor solution, ZeroWire Mobile ... the improvement of patient outcomes, procedural efficiency, and the lowering of ... ... By ...
(Date:10/7/2017)... 6, 2017   Provista, a proven leader ... billion in purchasing power, today announced a new resource ... The Newsroom is the online home for case ... expert bios, news releases, slideshows and events. ... wealth of resources at their fingertips, viewers can also ...
(Date:10/4/2017)... , Oct. 4, 2017  South Korean-based healthcare product ... training aide "cprCUBE" on Kickstarter. The device will educate ... cardiac arrests with better efficiency compared to the dated ... real-time feedback on efficacy of the compression for a ... has a goal to raise $5,000. ...
Breaking Medicine Technology:
Cached News: