HOME >> MEDICINE >> NEWS
NIAID begins enrolling volunteers for novel HIV vaccine study

A large clinical trial of a novel HIV vaccine has begun enrolling volunteers at sites in North America, South America, the Caribbean and Australia. Organizers are seeking 1,500 participants.

The trial is co-funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and the pharmaceutical company Merck & Co. Inc. Merck developed the experimental vaccine to stimulate HIV-specific cellular immunity, which prompts the body to produce T cells that kill HIV-infected cells. In previous smaller trials, this vaccine was found to be safe and to induce cellular immune responses against HIV in more than half of volunteers.

"This new study is the first time we have used such a large sample of people to test whether a vaccine that stimulates cellular immunity alone either blocks HIV infection, decreases the level of HIV early in infection or both," says Anthony S. Fauci, M.D., director of NIAID.

This proof-of-concept trial is designed to yield vital information on the potential efficacy of cellular immunity against HIV, although it is not expected to provide enough data to support immediate licensing of the vaccine for public use, says Margaret (Peggy) Johnston, Ph.D., who oversees HIV vaccine research at NIAID's Division of AIDS.

The Merck vaccine contains a weakened adenovirus that serves as a carrier for three subtype B HIV genes. Subtype B is the most prevalent HIV subtype in the regions of the study sites. Adenoviruses are among the main causes of upper respiratory tract ailments such as the common cold. Because the vaccine contains only three HIV genes housed in a weakened adenovirus, study participants cannot become infected with HIV or get a respiratory infection from the vaccine.

"If this study finds that the vaccine can prevent or control infection, we will work with Merck to evaluate the vaccine in a larger number of volunteers," adds Dr. Johnston. "We will al
'"/>

Contact: NIAID News Office
niaidnews@niaid.nih.gov
301-402-1663
NIH/National Institute of Allergy and Infectious Diseases
24-Jan-2005


Page: 1 2

Related medicine news :

1. NIAID initiates trial of experimental avian flu vaccine
2. NIAID seeks applicants to lead clinical trials units for revamped HIV/AIDS networks
3. NIAID-sponsored clinical trial aims to boost flu vaccine supply
4. NIAID seeks applicants to lead revamped HIV/AIDS clinical trials networks
5. NIAID launches influenza genome sequencing project
6. NIAID launches program to improve medical tools against emerging infectious diseases
7. NIAID forms network to tackle potentially fatal reaction to smallpox vaccine
8. NIAID rotavirus vaccine licensed for commercialization
9. Second NIAID SARS vaccine candidate helps mice fend off SARS
10. NIAID vaccine protects against SARS virus infection in mice
11. NIAID Ebola vaccine enters human trial

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:1/10/2020)... Fla. (PRWEB) , ... January 10, 2020 , ... The ... quality of sight is via a preventative approach. Leading eye care doctor, Brent Bellotte ... and cure of many common eye diseases. , Eyesight is something that many take ...
(Date:1/10/2020)... ... January 10, 2020 , ... ... provides a friendly, non-intimidating environment for all women. In search for a valuable ... current and prospective members. , For nearly 30 years, Balanced Habits, headquartered ...
(Date:1/8/2020)... ... January 08, 2020 , ... Pyxa Solutions, a leading ... that the company is rebranding as Red Nucleus R&D, a division of Red ... the life sciences industry. , The addition of Red Nucleus R&D under ...
(Date:1/8/2020)... ... January 08, 2020 , ... ... MedSpa in Living Magazine’s 2019 Best of Memorial Readers’ Choice Awards. ... high-quality skincare. Being named Best MedSpa in Memorial reflects Mirror Mirror Beauty Boutique’s ...
(Date:1/8/2020)... BOCA RATON, Fla. (PRWEB) , ... January 08, 2020 , ... ... with the purpose of providing a holistic care approach and to maintain a comfortable ... Beach communities. Mrs. Kavall has a passion for holistic care and has been a ...
Breaking Medicine News(10 mins):
(Date:1/7/2020)... ... 06, 2020 , ... Myant Inc., the pioneers in Textile Computing™, will be ... at CES 2020 (January 7-10, Las Vegas), including apparel from the Skiin Connected Health ... category of the CES 2020 Innovation Awards. , While electrocardiography, or the study of ...
(Date:1/3/2020)... ... January 03, 2020 , ... ScreenPoint ... to identify potential breast cancers earlier and faster, say a new international study ... using the Transpara system in 15 countries, including Hungary, Turkey, the USA and ...
(Date:1/3/2020)... ... January 03, 2020 , ... Complia Health announced today the ... will offer enterprise solutions for home, residential and community care in Canada, Australia ... and will move forward under the AlayaCare brand. , Procura has delivered home, ...
Breaking Medicine Technology:
Cached News: