"Elucidating the basic mechanisms of immune function is a major focus of our biodefense research agenda," says Anthony S. Fauci, M.D., director of NIAID. "The information generated by this program will deepen our understanding of how components of the immune system defend against certain infectious agents, enabling researchers to design new and improved medical countermeasures."
"Researchers have been conducting epitope discovery for many years, but generally on a small scale," says Daniel Rotrosen, M.D., director of NIAID's Division of Allergy, Immunology and Transplantation. "This initiative, however, will yield new knowledge about antigenic epitopes from a wide variety of microbes, including agents that might be used in a bioterrorist attack."
Epitopes are recognized by the body's B and T cells, white blood cells that detect an invading pathogen. Each B and T cell is specific for a particular antigen, meaning that each can only bind to a certain foreign molecular structure. This "specificity" is determined by the receptors on the surface of each cell.
Both B- and T-cell specificity as well as the diverse functions of these cells determine the effectiveness of an immu
Contact: Paul Williams
NIH/National Institute of Allergy and Infectious Diseases