NIAID vaccine protects against SARS virus infection in mice

An experimental vaccine prevents the SARS virus from replicating in laboratory mice, according to a new report in the April 1 issue of Nature. Scientists at the Vaccine Research Center (VRC) of the National Institute of Allergy and Infectious Diseases (NIAID), one of the National Institutes of Health, developed the vaccine. The vaccine was tested in a recently-described mouse model of SARS infection with other NIAID investigators.

The VRC scientists are preparing further experiments to evaluate the vaccine's safety and potential to induce similar immune responses in humans. The vaccine contains a small piece of SARS virus DNA, insufficient to reproduce the SARS virus, yet able to stimulate a protective immune response.

"This research was done in a remarkably short period of time, a testament to the serious attention and great cooperation the public health community has displayed in response to SARS. It has been just one year from identification of the SARS coronavirus to the development of this vaccine that has now proven effective against SARS in a laboratory animal," says Anthony S. Fauci, M.D., director of NIAID.

The DNA vaccine is made from a small piece of DNA that codes for a coat protein normally found on the outer surface of the SARS virus. This protein helps the SARS virus gain access to living cells, where it can cause infection. Because the DNA in the vaccine codes only for the protein, by itself it is unable to cause infection. NIAID scientists also modified the DNA so that it does not match the virus' genetic sequence to minimize the risk of it combining with the genetic material of SARS or other coronaviruses.

Most existing vaccines use killed or weakened forms of a whole virus or bacteria to protect against disease. This DNA vaccine works by directing the body's cells to make proteins very similar to those on the surface of the SARS virus. These proteins trigger the immune system to mount a defense e

Contact: Linda Joy
NIH/National Institute of Allergy and Infectious Diseases

Page: 1 2 3

Related medicine news :

1. NIAID initiates trial of experimental avian flu vaccine
2. NIAID seeks applicants to lead clinical trials units for revamped HIV/AIDS networks
3. NIAID begins enrolling volunteers for novel HIV vaccine study
4. NIAID-sponsored clinical trial aims to boost flu vaccine supply
5. NIAID seeks applicants to lead revamped HIV/AIDS clinical trials networks
6. NIAID launches influenza genome sequencing project
7. NIAID launches program to improve medical tools against emerging infectious diseases
8. NIAID forms network to tackle potentially fatal reaction to smallpox vaccine
9. NIAID rotavirus vaccine licensed for commercialization
10. Second NIAID SARS vaccine candidate helps mice fend off SARS
11. NIAID Ebola vaccine enters human trial

Post Your Comments:

(Date:9/1/2020)... ... September 01, 2020 , ... Board ... in Glendale. While the office will be the first to bear her name, ... buttock augmentation (Brazilian butt lift), as well as rhinoplasty, facial rejuvenation, and many ...
(Date:9/1/2020)... ... September 01, 2020 , ... ... fellowship training in aesthetic surgery of the face, breast, and body. In 2018, ... female-owned premier boutique plastic surgery and aesthetic practice in Southwest Florida. Dr. Gill ...
(Date:8/31/2020)... ... August 31, 2020 , ... Ocean Springs, Mississippi-based pharmaceutical distributor ... first responders across the United States. Since the start of the global COVID-19 ... medical centers , hospitals , firefighters , and public ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... to dental groups in the United States, today announced the grand opening of ... CA. , Patients will enjoy convenient hours, a comfortable office, and full-service ...
(Date:8/31/2020)... ... August 31, 2020 , ... Dr. ... with persons with autism and other developmental disabilities, as well as supporting staff ... education, adolescents with autism, school consultation, and staff development. She joined the company ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... August 26, 2020 , ... Unscrupulous sellers across ... Coronavirus. While air purification technologies, including GreenTech Environmental’s proprietary methods, have been used ... air purification system has published results of singular and scientific testing against the ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... CHPN, CHPCA, LNC has added CHC and CPCO to her name. , That’s ... in Healthcare Compliance (CHC) and the Certified Professional Compliance Officer (CPCO.) , The ...
(Date:8/26/2020)... , ... August 26, 2020 , ... ... the appointment of Claude E. Hooton as President and Chief Executive Officer effective ... Executive Chairman of the company’s Board of Managers. , Mr. Hooton, a ...
Breaking Medicine Technology:
Cached News: