A major aspect of ENCODE is testing of efficient, high-throughout methods for identifying, locating and fully analyzing all of the functional elements contained in a set of DNA target regions that covers approximately 30 megabases, or about 1 percent, of the human genome. If the pilot effort proves successful, the project will be expanded to cover the entire genome.
Additional ENCODE grants are made to:
Richard Myers, Ph.D., Stanford University, Palo Alto, Calif. "The Stanford ENCODE Project" First year funds, $2.7 million; total funds, $8 million.
George Stamatoyannopoulos, M.D., Dr. Sci., University of Washington, Seattle "Identification of Functional DNA Elements by HSqPCR" First year funds, $2.3 million; total funds, $6.9 million.
Michael Snyder, Ph.D., Yale University, New Haven, Conn. "Transcription and Regulatory Elements in ENCODE Regions" First year funds, $1.7 million; total funds, $4.9 million.
Thomas Gingeras, Ph.D., Affymetrix, Inc., Santa Clara, Calif. "Mapping Sites of Transcription and Regulation" First year funds, $990,000; total funds, $2 million.
Roderic Guigo, Ph.D., Municipal Institute of Medical Research, Barcelona, Spain "Encyclopedia of Genes and Gene Variants" First year funds, $570,000; total funds, $1.5 million.
Anindya Dutta, Ph.D., University of Virginia, Charlottesville "Mapping Replication Elements on Human Chromosomes" First year funds, $380,000; total funds, $1.1 million.
Ian Dunham, Ph.D., The Wellcome Trust Sanger Institute, Hinxton, U.K. "Detecting Human Functional Sequences with Microarrays" First year funds, $490,000; total funds, $730,000.
Zhiping Weng, Ph.D., Boston University "Alternative Promoter Usage in Tissue-Specific Gene Expression" First year funds, $530,000; total funds, $1.5 milli
Contact: Sue Pondrom
University of California - San Diego