er the new treatments that Newgard and Unger develop.Johnston, professor of internal medicine, will seek to exploit and develop the identification of peptides that bind to specific cell types to target genes and other molecules specifically to islet b-cells. In collaboration with Grayburn, he also will try to develop a novel physical method for targeted gene delivery that has merits on its own but that may also complement the biochemical approach.

Kodadek and Meidell will use their expertise in chemistry and molecular biology to develop a new approach for turning on specific genes in cells that circumvents the requirement for any prior knowledge of the naturally occurring transcription factors for that gene."Current therapies for diabetes and obesity are woefully inadequate, and I think it is going to take something bold like this program project to change that," Newgard said.

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Contact: Theresa Merola Hernandez
theresa.merola@utsouthwestern.edu
214-648-3404
UT Southwestern Medical Center
28-Sep-2000

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