in memory and the ability to perform tasks of daily living. "Because there is such a huge variability in these measures among individuals, we require lengthy trials with large numbers of people," Dr. Weiner said. "Finding biomarkers should be able to tell us with more sensitivity and specificity which interventions might actually halt progress of the disease, even before clinical signs of the disease appear."

"The advances we have made in genetics, pathology, cell biology and biochemistry have brought us a much greater understanding of the mechanism of Alzheimer's," Dr. Weiner said. "We have a large number of potential medications in the pipeline for slowing progression of the disease. The initiative holds out hope for developing effective medications to prevent the progression and, perhaps, the development of AD."
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Contact: Vicky Cahan
cahanv@nia.nih.gov
301-496-1752
American Medical Association
13-Oct-2004

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