Natural immune response reduces nerve damage; may lead to improved treatment for spinal cord injury

In a series of animal experiments, scientists show for the first time that damage to the central nervous system causes the body to mount an immune reaction against itself that actually protects neurons from further damage. The findings may lead to a vaccine to improve functional recovery following spinal cord injury.

The findings also challenge accepted dogma that immune activity in the central nervous system is harmful, and that immune response against the bodys own tissue, known as an autoimmune response, is destructive. We show that this autoimmune response can help the individual to cope with stress caused by the injury, says lead author Michal Schwartz, PhD, of the Weizmann Institute of Science in Rehovot, Israel. The study, funded in part by Proneuron, Ltd., an Israeli biotechnology company, appears in the June 1 issue of The Journal of Neuroscience. Schwartz has an equity position in Proneuron.

These studies provide new avenues for development of potential treatments and prevention of paralysis resulting from injury, says Esther Sternberg, MD, an expert on the interaction of the nervous system and immune system at the National Institute of Mental Health in Bethesda, MD.

The potential treatment could boost in a well-controlled way the natural protective autoimmune response, and thereby inhibit the cascade of normal damage that occurs after the initial trauma, such as spinal cord injury.

In four experiments in rats and mice, Schwarz and colleagues Eti Yoles and Ehud Hauben found that central nervous system trauma evokes a protective immune response that reduces neuronal loss.

The authors say that the ability to spontaneously mount a protective immune response does not exist in all individuals, but can be induced in deficient individuals or boosted if it exists. Since this response represents the bodys own attempt to heal itself, stimulating or boosting it is likely to provide the most comprehensive protection for damaged nerves.


Contact: Mary McComb
Society for Neuroscience

Page: 1

Related medicine news :

1. Aloe vera: Natural, home remedy treats canker and cold sores
2. Natural mentors help mold lives of teens, study says
3. Natural selection as we speak
4. Natural plant oil does not improve eczema
5. Natural scenes calm drivers more than city views, study finds
6. Clemson Scientists Refining Natural Immune System Booster
7. PITT Researchers Demonstrate Human Brains Natural Mechanism For Guarding Against Errors
8. Researchers Study Natural Screen For Cancer
9. Natural Estrogens May Help Protect Women From Brain Damage During Stroke
10. Chemists identify immune system mechanism for methamphetamine binges
11. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression

Post Your Comments:

(Date:9/1/2020)... ... 01, 2020 , ... KitoTech Medical, a Seattle-based medical device ... will be used to accelerate the commercialization of its microMend® family of wound ... continue to expand its customer base of healthcare systems as well as independent ...
(Date:8/31/2020)... ... , ... Cardiothoracic surgeons at Allegheny General Hospital (AGH), part ... (CMU) to develop a new heart monitoring device designed to serve as an ... AGH/CMU team was recently awarded a “Trailblazer” grant from the National Institutes of ...
(Date:8/31/2020)... (PRWEB) , ... August 31, 2020 , ... Want to ... 1, Cerebral Palsy Alliance Research Foundation (CPARF) is thrilled to launch its fourth annual ... research. A fully virtual challenge, STEPtember meets everyone wherever they are at this moment ...
(Date:8/31/2020)... Ga. (PRWEB) , ... August 31, 2020 , ... The pandemic and topsy-turvy economic outlook ... examine our budgets and look for ways to trim the fat from our monthly expenses ... your finances, but it’s also important that you have a financial safety net in place ...
(Date:8/31/2020)... ... August 31, 2020 , ... ... improve outcomes for patients with advanced heart failure, today announced that the company ... the amount of $555,358 from the National Heart, Lung, and Blood Institute of ...
Breaking Medicine News(10 mins):
(Date:8/26/2020)... ... August 26, 2020 , ... ScripHessco has ... Injuries. The infographic breaks down ways that chiropractors can help heal sports injuries ... to ScripHessco “Athletes have an unusual amount of pressure and stress on their ...
(Date:8/26/2020)... Va. (PRWEB) , ... August ... ... (CEA) Holdings company today announced that it has entered into definitive agreement ... professionals CME/CE, primarily focused on pharmacists and pharmacy technicians. , CEA ...
(Date:8/26/2020)... ... August 26, 2020 , ... The ... funding innovative lymphoma research and serving the lymphoma community through education programs, outreach ... virtual LRF Gala and Charity Auction on Wednesday, Sept. 30 . ...
Breaking Medicine Technology:
Cached News: