HOME >> MEDICINE >> NEWS
Neoadjuvant and adjuvant systemic therapy for breast cancer give equivalent survival, study finds

The timing of systemic therapy--chemotherapy or endocrine therapy--for breast cancer does not appear to affect survival or disease progression. However, women who receive systemic therapy and radiation therapy without surgery may be more likely to experience a recurrence of their cancer compared with women treated with chemotherapy later, according to a new study in the February 2 issue of the Journal of the National Cancer Institute.

Neoadjuvant--also called preoperative or primary--systemic therapy for breast cancer may result in local tumor regression or even in a complete tumor response and may lead to a more limited extent of surgery--from radical mastectomy to some type of breast-conserving surgery--without risking patient survival. For these reasons, interest in the use of neoadjuvant therapy has been increasing.

To investigate how the timing of systemic therapy affects breast cancer outcomes, John P.A. Ioannidis, M.D., of the University of Ioannina School of Medicine in Greece, and colleagues performed a meta-analysis of nine randomized trials that had included nearly 4,000 breast cancer patients. The patients had been treated with systemic therapy either before or after surgery and/or radiation therapy.

There was no difference between neoadjuvant and adjuvant systemic therapy in terms of death, disease progression, or distant disease recurrence. However, neoadjuvant therapy was associated with a 22% increased risk of loco-regional disease recurrence compared with adjuvant therapy. This risk was higher (53%) when radiation therapy was used without surgery.

"[T]his meta-analysis demonstrates the equivalence of neoadjuvant and adjuvant treatments for breast cancer in terms of survival, disease progression, and distant recurrence and shows that an increased risk of loco-regional disease recurrence is associated with neoadjuvant treatment, especially when primary systemic treatment is not accompanied by any surgical interve
'"/>

Contact: Sarah L. Zielinski
jncimedia@oupjournals.org
301-841-1287
Journal of the National Cancer Institute
1-Feb-2005


Page: 1 2

Related medicine news :

1. MRI better than current standard in assessing neoadjuvant chemotherapy for breast cancer
2. Updated adjuvant data presented at SABCS show 30 percent reduction in recurrence
3. Different methods of adjuvant chemotherapy for colorectal cancer have similar outcomes
4. Study supports tailoring adjuvant therapy for early-stage breast cancer
5. Nordic collaboration gives new insights into adjuvant chemotherapy
6. Tumor-targeted immune cells cure prostate cancer in mice without causing systemic immune suppression
7. A blood test may reveal systemic factors that relate to periodontal disease, especially in men
8. Important information to consider about non-systemic cholesterol lowering agents
9. Study shows patch therapy may be as effective as oral medications
10. Novel therapy tested in mice could chase away cat allergies
11. Drug therapy may be comparable to invasive cardiac procedures for elderly patients with heart attack

Post Your Comments:
(Date:7/29/2015)... ... July 29, 2015 , ... ... delivery model, application, end user and region. Factors such as the rising pressure ... benefits of analytics, and increase in venture capital investments are driving market growth. ...
(Date:7/29/2015)... (PRWEB) , ... July 29, 2015 , ... ... shops are anticipating testing regulations imposed by the FDA for nicotine laced liquid ... use of electronic cigarettes have raised considerably. E-Cigarettes are particularly troublesome to addiction ...
(Date:7/29/2015)... , ... July 29, 2015 , ... Orthopedic surgeons at ... offer the Rotation Medical Rotator Cuff System, a new implant to treat a common ... designed to foster natural regeneration of additional tendon tissue, which could allow for faster ...
(Date:7/29/2015)... York, NY (PRWEB) , ... July 29, 2015 , ... ... were approved by USCIS over the past month! I-829 approvals have been granted to ... in Los Angeles, the Kimpton Lafayette Hotel project in Philadelphia, and the Valley ...
(Date:7/29/2015)... , ... July 29, 2015 , ... It is unique ... “This is a tremendous model of care. One that is very hands on and ... executive director of Monarch Landing. “She’s bringing great passion and energy, as well as ...
Breaking Medicine News(10 mins):Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 2Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 3Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 4Health News:Healthcare Analytics Market Growing at 26.5% CAGR to 2020 5Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 2Health News:Harbor Village Urges South Florida Residents to Abstain from the Use of E Cigarettes 3Health News:Lourdes Orthopedics First in NJ to Offer Bioinductive Implant for Rotator Cuff Repair 2Health News:Lourdes Orthopedics First in NJ to Offer Bioinductive Implant for Rotator Cuff Repair 3Health News:More Than 60 New I-829 Approvals in Less Than 30 days for CanAm 2Health News:More Than 60 New I-829 Approvals in Less Than 30 days for CanAm 3Health News:New Medical Director Readies To Take Reins at Monarch Landing 2Health News:New Medical Director Readies To Take Reins at Monarch Landing 3
(Date:7/29/2015)... July 29, 2015 According to ... " Active Pharmaceutical Ingredients (API) Market - Global Industry ... 2020 " the global active pharmaceutical ingredients market was ... anticipated to reach USD 185.9 billion by 2020, expanding ... from 2014 to 2020. Full Research Report ...
(Date:7/29/2015)... -- Medical Care Alert, a leading national provider of personal ... its new HOME & AWAY ELITE mobile GPS ... on the hip, the small two-ounce pendant can summon ... using the AT&T Wireless network. The HOME ... and automatic fall detection medical alert systems. ...
(Date:7/29/2015)... CHENNAI, India , July 29, 2015 TAKE ... its foray into the big data market for the Life ... new US-based subsidiary, with an initial investment of 3 ... billion healthcare and life sciences market (according to projections by ... integration and advanced analytics. ...
Breaking Medicine Technology:Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 2Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 3Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 4Active Pharmaceutical Ingredients Market Expected to Reach USD 185.9 Billion Globally in 2020: Transparency Market Research 5New Medical Care Alert Pendant Combines GPS, Cellular Voice, and Automatic Fall Detection 2New Medical Care Alert Pendant Combines GPS, Cellular Voice, and Automatic Fall Detection 3New Medical Care Alert Pendant Combines GPS, Cellular Voice, and Automatic Fall Detection 4TAKE Solutions Creates a New Subsidiary for Life Sciences Big Data in the US 2TAKE Solutions Creates a New Subsidiary for Life Sciences Big Data in the US 3
Cached News: