HOME >> MEDICINE >> NEWS
Nerve navigation findings prompt new direction for spinal cord research

A piece of the puzzle of how nerves find their way across the midline of the brain and spinal cord in a developing embryo has been found by Medical College of Georgia researchers.

They have found that an enzyme called focal adhesion kinase tells the arm-like extension of a neuron to cross the midline of the spinal cord, says Dr. Wen-Cheng Xiong, developmental neurobiologist and lead author on the paper in the November issue of Nature Neuroscience.

After crossing, the axon becomes part of the complex network that enables the right side of the brain to control the left side of the body and vice versa.

The finding helps explain normal development of the nervous systems and provides a new target in the search for ways to re-establish connections and the movement and feeling they enable lost to spinal cord injuries.

"This kinase plays a role in helping direct axon movement across the spinal cord during development," Dr. Xiong says. "How it does that is one of the questions we hope to answer next. We still have a lot of questions." Among those is why this mechanism doesn't seem to work after development is complete. "If the spinal cord is injured, why doesn't it re-cross that boundary?" she says. "Why are these molecules not functioning well in the adult?"

Focal adhesion kinase already is a hot topic among scientists studying how cells migrate and how tumor cells spread. Now, Dr. Xiong and her collaborators have found the enzyme also plays an important role in central nervous system development.

She explains that for axons to journey across the spinal cord, floor plate cells along this natural midline of the developing body secrete a guidance or cue factor called netrin-1. "If this molecule is deleted, this axon cannot cross. It just stays on this side" and the developing embryo will die, a testimony to netrin's expansive role in getting cells where they need to be. "T
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
26-Oct-2004


Page: 1 2 3

Related medicine news :

1. Nerve damage from alcoholism reversed after liver transplantation
2. Vagus Nerve Stimulation Therapy (TM) more effective in epilepsy patients when used earlier
3. Nerve Cells Live Long And Talkative Lives In Sculpted Colonies On Silicon Chips
4. Cut Nerve Fibers Are Repaired In An Animal Model of Spinal Cord Injury; May Help Repair Nerve Damage In Humans
5. Percutaneous Electrical Nerve Stimulation May Offer Dramatic Short-Term Relief For Chronic Back Pain
6. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
7. Electrical Nerve Stimulation May Help Reduce Chronic Pain In Cancer Patients, Say UT Southwestern Researchers
8. Nerve Agent Sensor A Million Times More Sensitive
9. Study Shows Potential For Quelling AIDS Nerve Pain
10. Video game used for study of human navigation
11. Rush begins use of magnetic guided navigation system

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:4/1/2020)... ... April 02, 2020 , ... Medical Device Change Management, An FDAnews Webinar ... , What change management method should one be using for a medical device? ... the type of change. Is it due to post-market design change, production process changes, ...
(Date:4/1/2020)... ... 2020 , ... “Medical information is considered to be among ... LLP attorney Eric A. Grover. “For that reason, healthcare providers are required ... disclosure of medical information can, under certain circumstances, give rise to claims by ...
(Date:3/28/2020)... ... 27, 2020 , ... The construction industry is taking essential ... coronavirus. Operating under the designation as an essential business as modified today by ... projects in the downstate New York region. , While certain projects have been ...
(Date:3/27/2020)... ... March 27, 2020 , ... ... by NJ Top Docs. Dr. Kubeck has been approved every year consecutively since ... and specializes in Spinal Surgery. , Dr. Kubeck’s medical education began at ...
(Date:3/22/2020)... ... March 21, 2020 , ... In partnership with UC Health, ... our community’s medical professionals and first responders. The title comes from the English translation ... city and its flag. , Proceeds from the sale of the shirt will ...
Breaking Medicine News(10 mins):
(Date:4/2/2020)... BOSTON (PRWEB) , ... April 02, 2020 , ... ... on Clinical Research Participation (CISCRP) will be initiating the 2nd annual Medical Hero ... for all “Medical Heroes” – medical and healthcare professionals, researchers and study volunteers. ...
(Date:4/1/2020)... MINNEAPOLIS (PRWEB) , ... April 01, 2020 , ... ... BioMax has begun producing reusable face shields. As large manufacturers nation-wide scramble to ... to make do reusing masks or in extreme cases, using hand-sewn masks to ...
(Date:3/30/2020)... ... March 30, 2020 , ... “In ... business continuity. Unfortunately, we hear stories from our customers of vendor price-gouging. We ... take advantage of people’s hardships in this difficult time,” says Borya Shakhnovich, CEO ...
Breaking Medicine Technology:
Cached News: