HOME >> MEDICINE >> NEWS
Nerve navigation findings prompt new direction for spinal cord research

his factor plays a critical role for nearly all the neurons to cross the midline, even in the cortex or hippocampus of the brain," Dr. Xiong says.

A receptor on the axon called DCC, or Deleted in Colon Cancer, responds to the signal from netrin. But why the axon knows to move in a certain direction once it sees that signal was an unknown, Dr. Xiong says. The researchers have now found that once this receptor binds to netrin, focal adhesion kinase is activated that tells the axon to reorganize its structure or cytoskeleton and the restructured axon knows how to move. When they delete the kinase, the axon doesn't make the proper journey or the proper connection.

Developing axons can sense and navigate their environment but how the two functions work together to result in the axon getting where it needs to be is poorly understood, Dr. Xiong says. "Everybody in the developmental neurobiology field is wondering what is the mechanism, how the neuron, once it senses the environment, couples with the motor activity. This provides information for that kind of puzzle," she says of the newly published work.

The researchers are looking for other molecules that also play a role in directing axonal growth. "We have lots of information about how this molecule talks with other molecules," Dr. Xiong says. "We just need to get a system to figure out how they talk to each other."

She's also moving toward an injury model to see what happens to this molecular talk after a spinal cord injury. "We know this factor can turn on but we don't know how it turns on. If you sever the spinal cord, the important crossing of the axon is gone. Right now, we don't know how to make it go back."

Drs. Xiong's MCG collaborators on the study include her husband, Dr. Lin Mei, also a developmental neurobiologist; research technician Zhu Feng and graduate student Qiang Wang as well as researchers at the
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
26-Oct-2004


Page: 1 2 3

Related medicine news :

1. Nerve damage from alcoholism reversed after liver transplantation
2. Vagus Nerve Stimulation Therapy (TM) more effective in epilepsy patients when used earlier
3. Nerve Cells Live Long And Talkative Lives In Sculpted Colonies On Silicon Chips
4. Cut Nerve Fibers Are Repaired In An Animal Model of Spinal Cord Injury; May Help Repair Nerve Damage In Humans
5. Percutaneous Electrical Nerve Stimulation May Offer Dramatic Short-Term Relief For Chronic Back Pain
6. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
7. Electrical Nerve Stimulation May Help Reduce Chronic Pain In Cancer Patients, Say UT Southwestern Researchers
8. Nerve Agent Sensor A Million Times More Sensitive
9. Study Shows Potential For Quelling AIDS Nerve Pain
10. Video game used for study of human navigation
11. Rush begins use of magnetic guided navigation system

Post Your Comments:
(Date:4/17/2014)... CHAMPAIGN, Ill. One of the most popular vaccine ... choice. And doctors may be overlooking some cost factors ... actually a more expensive option, according to a new ... of vaccines to administer can be driven by numerous ... study and a professor of computer science and of ...
(Date:4/17/2014)... April issue of Experimental Biology and Medicine ... Rex Gaskins and Paul Kenis in the Institute ... the University of Illinois Urbana-Champaign describe their recent ... underlie a variety of cell functions including energy ... crucial roles in regulating normal cellular behavior, redox ...
(Date:4/17/2014)... Colo. (April 17, 2014) Two recent papers ... researcher and colleagues may help scientists develop treatments ... Yellow fever, Japanese encephalitis and other disease-causing flaviviruses. ... biochemistry and molecular genetics at the School of ... Howard Hughes Medical Institute, and colleagues recently published ...
(Date:4/17/2014)... Le Bonheur Children,s Hospital Pediatrician-in-Chief Jon McCullers, MD, ... the April issue of Nature Reviews Microbiology ... Dr. McCullers, a world-renowned infectious disease specialist, ... the University of Tennessee Health Science Center, analyzed ... 1918, 1957 and 1968 pandemics, as well as ...
(Date:4/17/2014)... 2014U.S. military personnel who served in Iraq and ... brain injury (TBI) were compared to military personnel ... reasons. Differences in measures of overall disability, cognitive ... injury are reported in an article in ... Mary Ann Liebert, Inc., publishers. The article is ...
Breaking Medicine News(10 mins):Health News:Study recalculates costs of combination vaccines 2Health News:Live cell imaging reveals distinct alterations of subcellular glutathione potentials 2Health News:CU researchers discover target for treating dengue fever 2Health News:Long-term effects of battle-related 'blast plus impact' concussive TBI in US military 2
(Date:1/15/2014)... Ill. , Jan. 15, 2014 The Cadence ... Medical Fitness Center by the Medical Fitness Association, a ... to achieve their full potential. The Cadence Fitness & ... the western suburbs and second in the Chicagoland area. ...
(Date:1/15/2014)... NEW YORK , Jan. 15, 2014 ... research report is available in its catalogue: ... & Forecast – Worldwide Analysis ... Pump Market Analysis ...
(Date:1/15/2014)... Quebec , Jan. 15, 2014  Valeant Pharmaceuticals International, ... announced that the applicable waiting period under the Hart-Scott-Rodino ... the previously announced tender offer by its indirect wholly-owned ... outstanding shares of common stock of Solta Medical, Inc. ...
Breaking Medicine Technology:Cadence Fitness & Health Center Certified as Medical Fitness Facility 2Cadence Fitness & Health Center Certified as Medical Fitness Facility 3Insulin Pump Market & Forecast - Worldwide Analysis 2Insulin Pump Market & Forecast - Worldwide Analysis 3Insulin Pump Market & Forecast - Worldwide Analysis 4Insulin Pump Market & Forecast - Worldwide Analysis 5Insulin Pump Market & Forecast - Worldwide Analysis 6Insulin Pump Market & Forecast - Worldwide Analysis 7Insulin Pump Market & Forecast - Worldwide Analysis 8Insulin Pump Market & Forecast - Worldwide Analysis 9Insulin Pump Market & Forecast - Worldwide Analysis 10Insulin Pump Market & Forecast - Worldwide Analysis 11Insulin Pump Market & Forecast - Worldwide Analysis 12Insulin Pump Market & Forecast - Worldwide Analysis 13Insulin Pump Market & Forecast - Worldwide Analysis 14Insulin Pump Market & Forecast - Worldwide Analysis 15Insulin Pump Market & Forecast - Worldwide Analysis 16Insulin Pump Market & Forecast - Worldwide Analysis 17Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 2Valeant Pharmaceuticals Announces Receipt Of Antitrust Clearance For Its Previously Announced Acquisition Of Solta Medical, Inc. 3
Cached News: