HOME >> MEDICINE >> NEWS
Nerve navigation findings prompt new direction for spinal cord research

his factor plays a critical role for nearly all the neurons to cross the midline, even in the cortex or hippocampus of the brain," Dr. Xiong says.

A receptor on the axon called DCC, or Deleted in Colon Cancer, responds to the signal from netrin. But why the axon knows to move in a certain direction once it sees that signal was an unknown, Dr. Xiong says. The researchers have now found that once this receptor binds to netrin, focal adhesion kinase is activated that tells the axon to reorganize its structure or cytoskeleton and the restructured axon knows how to move. When they delete the kinase, the axon doesn't make the proper journey or the proper connection.

Developing axons can sense and navigate their environment but how the two functions work together to result in the axon getting where it needs to be is poorly understood, Dr. Xiong says. "Everybody in the developmental neurobiology field is wondering what is the mechanism, how the neuron, once it senses the environment, couples with the motor activity. This provides information for that kind of puzzle," she says of the newly published work.

The researchers are looking for other molecules that also play a role in directing axonal growth. "We have lots of information about how this molecule talks with other molecules," Dr. Xiong says. "We just need to get a system to figure out how they talk to each other."

She's also moving toward an injury model to see what happens to this molecular talk after a spinal cord injury. "We know this factor can turn on but we don't know how it turns on. If you sever the spinal cord, the important crossing of the axon is gone. Right now, we don't know how to make it go back."

Drs. Xiong's MCG collaborators on the study include her husband, Dr. Lin Mei, also a developmental neurobiologist; research technician Zhu Feng and graduate student Qiang Wang as well as researchers at the
'"/>

Contact: Toni Baker
tbaker@mcg.edu
706-721-4421
Medical College of Georgia
26-Oct-2004


Page: 1 2 3

Related medicine news :

1. Nerve damage from alcoholism reversed after liver transplantation
2. Vagus Nerve Stimulation Therapy (TM) more effective in epilepsy patients when used earlier
3. Nerve Cells Live Long And Talkative Lives In Sculpted Colonies On Silicon Chips
4. Cut Nerve Fibers Are Repaired In An Animal Model of Spinal Cord Injury; May Help Repair Nerve Damage In Humans
5. Percutaneous Electrical Nerve Stimulation May Offer Dramatic Short-Term Relief For Chronic Back Pain
6. Hunter College Biologist Marie Filbin Identifies Mechanism That Blocks All Inhibitors Of Nerve Regeneration; Breakthrough Reported In Neuron Magazine
7. Electrical Nerve Stimulation May Help Reduce Chronic Pain In Cancer Patients, Say UT Southwestern Researchers
8. Nerve Agent Sensor A Million Times More Sensitive
9. Study Shows Potential For Quelling AIDS Nerve Pain
10. Video game used for study of human navigation
11. Rush begins use of magnetic guided navigation system

Post Your Comments:
(Date:7/28/2015)... ... July 29, 2015 , ... Meet a Millionaire, ... A-Listers, has evolved into a world class millionaires club, according to the site’s ... successful and attractive people seeking real, meaningful and mutually beneficial relationships and provide ...
(Date:7/28/2015)... ... ... Talking About Your Product Pipeline:, How FDA and SEC Regulate Life Sciences ... http://www.fdanews.com/productpipeline , When a company has a product in development, whether drug, device ... regulated by the FDA. , At the same time, the SEC requires that information ...
(Date:7/28/2015)... ... July 29, 2015 , ... ... as a 2015-2016 inductee into its VIP Woman of the Year Circle. ... the nation's leading networking organization exclusively for professional women, boasting more than 700,000 ...
(Date:7/28/2015)... ... July 29, 2015 , ... City Sports, a specialty sports retailer and a ... Marty Hanaka as CEO. , Hanaka, who has served on the Board of Directors ... at the Highland Consumer Fund has had previous tenures as Chairman and CEO of ...
(Date:7/28/2015)... ... July 28, 2015 , ... Every July, since 2007, ... the disease only experience through movies and television. They go to summer camp. , ... right side of the heart as it pushes hard to get blood through arteries ...
Breaking Medicine News(10 mins):Health News:Meet a Millionaire Announces It’s Not a Sugar Daddy Site, It’s a True Millionaires Club 2Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 2Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 3Health News:FDAnews Announces — Talking About Your Product Pipeline: How FDA and SEC Regulate Life Sciences Communications Webinar, Aug. 19, 2015 4Health News:National Association of Professional Women Inducts Susan Bentley, Owner of Women's Wellness Options, Into its VIP Woman of the Year Circle 2Health News:City Sports Names Marty Hanaka CEO 2Health News:Special Summer Camp Gives Pulmonary Hypertension Patients Experiences Typically Out of Reach for Kids with their Condition 2Health News:Special Summer Camp Gives Pulmonary Hypertension Patients Experiences Typically Out of Reach for Kids with their Condition 3
(Date:7/28/2015)... 28, 2015 Codman Neuro*, part of DePuy ... new platform of embolic coils for the treatment of ... to improve microcatheter stability and provide an optimized detachment ... here at the Society of NeuroInterventional Surgery (SNIS) 12 ... framing, filling and finishing coils used during a minimally ...
(Date:7/28/2015)... Calif. , July 28, 2015 Amgen ... Directors today declared a $0.79 per share dividend for ... paid on Sept. 8, 2015, to all stockholders of ... 17, 2015.  About Amgen Amgen is ... suffering from serious illnesses by discovering, developing, manufacturing and ...
(Date:7/28/2015)... -- Insulet Corporation (NASDAQ: PODD ), the leader in ... Insulin Management System, today announced that Dr. Jessica ... Directors. Dr. Hopfield brings more than two ... She currently serves as the Vice Chair of the ... diabetes research center, diabetes clinic, and provider of diabetes ...
Breaking Medicine Technology:Codman Neuro Launches Family Of Coils For Treatment Of Brain Aneurysms 2Codman Neuro Launches Family Of Coils For Treatment Of Brain Aneurysms 3Codman Neuro Launches Family Of Coils For Treatment Of Brain Aneurysms 4Amgen Announces 2015 Third Quarter Dividend 2Amgen Announces 2015 Third Quarter Dividend 3Insulet Appoints Jessica Hopfield, PhD, to Board of Directors 2Insulet Appoints Jessica Hopfield, PhD, to Board of Directors 3
Cached News: