HOME >> MEDICINE >> NEWS
Neuronal death and processing of Tau protein in Alzheimer's disease

In a research report recently published in the Journal of Alzheimer's Disease (http://www.j-alz.com), published by IOS Press, a research group from the International School for Advanced Studies (ISASSISSA) in Trieste (Luisa Fasulo, Gabriele Ugolini e Antonino Cattaneo) showed that a processed form of tau protein induces neuronal death by apoptosis (programmed cell death) when expressed in cultured rat hippocampal neurons. Pathological changes in the microtubule associated protein tau are a major hallmark of the human dementias collectively defined as tauopathies, including Alzheimer's disease (AD). In Fronto-Temporal Dementia with Parkinsonism linked to Chromosome 17 (FTDP-17), several mutations in the tau gene were identified showing that primary malfunction of tau can lead to neurodegeneration. Such findings shed new light on the role of post-translational modifications of tau protein occurring in other tauopathies (such as AD), including aberrant proteolysis. In AD, tau protein aggregates in intraneuronal deposits known as "neurofibrillary tangles" (NFT), one of the two hallmarks of the disease. Tau molecules normally associate to microtubules (major cytoskeletal structures); in AD, tau proteins dissociate from microtubules and aggregate into NFTs.

Inappropriate neuronal apoptosis (or neuronal cell death) is present in AD, as well as in other neurodegenerative diseases. In a previous study, the authors showed that tau is a substrate for the apoptotic protease caspase-3 (an enzyme involved in cell death processes) and an effector of apoptosis itself, in established cell lines. Moreover, the cleavage of tau by caspase-3 has been recently confirmed to occur "in vivo" in AD brain as an early event. The study shows the apoptotic properties of tau fragments in cultured hippocampal neurons, a neuronal subpopulation precociously affected by AD pathology.

According to the authors, neurodegeneration would be perpetuated b
'"/>

Contact: Mauro Scanu
scanu@sissa.it
39-040-378-7557
Case Western Reserve University
15-Mar-2005


Page: 1 2

Related medicine news :

1. Neuronal differences in certain brain regions observed in chronic users of cocaine
2. New study in Nature demonstrates protection against cell death during heart attack
3. Mouse model reveals potential way to reduce cardiac deaths in kidney patients
4. New estimates for the causes of child deaths worldwide
5. Cardiac deaths peak in sleep hours for patients with sleep apnea
6. Sudan surveys show high rates of death and malnutrition among displaced population
7. Risk of cardiac death after radiotherapy for breast cancer has declined, study finds
8. Study shows risk of cardiac death after radiation for breast cancer has dramatically decreased
9. New guideline tackles leading cause of mother and child death
10. Tobacco industry pays scientists to challenge secondhand smokes link to infant death risk
11. Heart surgeons publish death rates

Post Your Comments:
*Name:
*Comment:
*Email:


(Date:2/19/2020)... ... February 19, 2020 , ... Spaulding Youth Center is thrilled ... Doug Flutie, Jr. Foundation for Autism. The grant will directly support Spaulding’s initiative ... fitness program will include the hiring of a fitness professional who will complete ...
(Date:2/19/2020)... ... February 19, 2020 , ... The American College of Lifestyle ... Lifestyle Medicine Residency Curriculum (LMRC). The curriculum is the first comprehensive, applicable and ... Driven by resident involvement, the curriculum has included residents in every aspect of ...
(Date:2/19/2020)... ... February 19, 2020 , ... ... Founders Encouraged to Apply to Participate in 2020 Cohort , The Massachusetts Medical ... program is now accepting applications from startup founders and CEOs to participate ...
(Date:2/19/2020)... Mass. (PRWEB) , ... February 19, 2020 , ... ... the quality and consistency of healthcare delivery, announced that it will participate in ... 2020, in Orlando, Florida. BPM+ Health will engage healthcare professionals and other stakeholders ...
(Date:2/19/2020)... ... ... SEAL SHIELD, LLC - Almost a hundred thousand people are dying in the ... for Disease Control (CDC), 80% of infections are transmitted by hands. But what hasn’t ... an extension of people’s hands, but not getting cleaned nearly as often, if ever. ...
Breaking Medicine News(10 mins):
(Date:2/28/2020)... S.D. (PRWEB) , ... February 28, 2020 , ... In ... on the spread of the COVID-19 (known as coronavirus), South Dakota School of ... be cautious and use common sense. , “Don’t panic, but be prepared,” Racz ...
(Date:2/28/2020)... ... February 27, 2020 , ... zPaper ... in the Salesforce® ecosystem, announced today that its Unified, End-to-End Document and Data ... status demonstrates that the zPaper Document and Data Automation Platform for Salesforce®, with ...
(Date:2/28/2020)... ... February 27, 2020 , ... At the VA Maryland Health Care System, ... or tablets with the VA Video Connect application. Since its rollout in July 2019, ... secure, live video telehealth appointments. The VA Video Connect app has proven to be ...
Breaking Medicine Technology:
Cached News: