Neurotransmitter-Induced Electrical Activity Identified As Key Regulator Of Synaptogenesis

cultured spinal neurons with tetrodotoxin Kirsch and Betz now found that electrical activity is required for glycine receptor clustering. In a second step, they investigated whether electrical activity induced by activation of the glycine receptor itself might be an important component in this process. Therefore, neuronal cultures were treated with the highly selective glycine receptor antagonist strychnine. This treatment abolished both gephyrin and glycine receptor clustering in a dose-dependent manner. Knowing that glycine receptor activation in embryonic neurons can result in membrane depolarization and the opening of voltage-gated calcium channels, spinal cord cultures were treated with calcium channel antagonists and again, receptor clustering was strongly reduced.

The data suggest the following model for postsynaptic membrane formation: Initially glycine receptors are diffusely distributed in the neuronal plasma membrane. Whenever receptors, encounter freely diffusing an active nerve terminal releasing the appropriate neurotransmitter, namely glycine, they open and the resulting ion flux generates a local change in membrane potential. This induces the opening of voltage-gated calcium channels. The resulting calcium influx triggers a second messenger cascade which together with additional presynaptic effectors causes the aggregation of gephyrin beneath the activated plasmamembrane. The aggregates of this peripheral membrane protein then act as a diffusion trap for additional glycine receptor polypeptides. This passive mechanism concentrates the receptors at the developing postsynaptic site.

In the forties, Donald Hebb postulated that the coincident activity of both pre- and

Contact: Joachim Kirsch & Heinrich Betz

Page: 1 2 3

Related medicine news :

1. Electrical stimulation in patients with paralysis and spinal cord injury
2. Electrical brain stimulation reduces Parkinsons symptoms
3. Percutaneous Electrical Nerve Stimulation May Offer Dramatic Short-Term Relief For Chronic Back Pain
4. Electrical Nerve Stimulation May Help Reduce Chronic Pain In Cancer Patients, Say UT Southwestern Researchers
5. Activity not out of the question for people with chronic pain
6. Psychologist Detects Brain-Activity Changes In Maltreated Kids
7. Brain Activity Differs In Introverts And Extroverts, UI Study Shows
8. Growing Younger By Keeping Up Regular Physical Activity
9. Effects Of Physical Activity On Preterm Birth
10. Major Causes Of Early Childhood Death From Injury Identified
11. Brain Regions Identified That Influence What We Remember Or Forget

Post Your Comments:

(Date:11/26/2015)... ... November 26, 2015 , ... Health-E-minds ... collaborated with Women’s Web – an online resource for Indian women looking ... and emotional well-being relationship, life balance, stress, professional development, and lifestyle. Health-E-minds ...
(Date:11/25/2015)... ... 25, 2015 , ... The holiday season is jam-packed with ... palates of attendees is of the utmost importance. Whether you are cooking at ... these recipes a try this holiday season. , Turkey Croquettes , ...
(Date:11/25/2015)... ... November 25, 2015 , ... Dr. John Pierce, Medical Director at the Ageless ... treatment with the Capillus272™ Pro laser therapy cap. FDA cleared for safety and efficacy, ... without the need for surgery, prescription pills, or topical foams. , “Capillus272™ Pro ...
(Date:11/25/2015)... ... 25, 2015 , ... According to an article published November 10th ... widely heralded as a breakthrough for performing hernia repairs. The article explains that the ... is that it can greatly reduce the pain that a patient might otherwise experience ...
(Date:11/25/2015)... ... November 25, 2015 , ... ... athletic programs, launches new Wimbledon Athletics Facebook page to educate the ... for unsuspected cardiac abnormalities. About 2,000 people under the age of 25 die ...
Breaking Medicine News(10 mins):
(Date:11/26/2015)... Nov. 26, 2015 Research and Markets ( ... "Advanced Wound Care Market by Type (Dressings, Therapy Devices, ... (In-Patient Facility, Out-Patient Facility), and Geography - Global Forecast ... --> --> The purpose ... and forecast of the global advanced wound care market. ...
(Date:11/26/2015)... India , November 26, 2015 ... --> RnRMarketResearch.com adds ... Report" and "Investigation Report on China ... and 2021 forecasts data and information ... http://www.rnrmarketresearch.com/global-repaglinide-industry-2015-market-research-report-market-report.html . ...
(Date:11/26/2015)... , Nov. 26, 2015 Research ... addition of the "2016 Future Horizons and ... (TDM) Market: Supplier Shares, Country Segment Forecasts, Competitive ... --> --> ... analysis of the Italian therapeutic drug monitoring market, ...
Breaking Medicine Technology:
Cached News: